The Effect of Resveratrol on Neurodegeneration and Blood Brain Barrier Stability Surrounding Intracortical Microelectrodes

Potter, Kelsey A.; Buck, Amy C.; Self, Wade K.; Callanan, Megan E.; Sunil, Smrithi; Capadona, Jeffrey R.

doi:10.1016/j.biomaterials.2013.05.035

Cited by 129Neuroscience and Neural EngineeringNeuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular Disturbances

The Effect of Resveratrol on Neurodegeneration and Blood Brain Barrier Stability Surrounding Intracortical Microelectrodes

Potter, Kelsey A., Buck, Amy C., Self, Wade K., Callanan, Megan E., Sunil, Smrithi, Capadona, Jeffrey R.·2013·Biomaterials

DOI 10.1016/j.biomaterials.2013.05.035

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Abstract

The current study seeks to elucidate a biological mechanism which may mediate neuroinflammation, and decreases in both blood-brain barrier stability and neuron viability at the intracortical microelectrode-tissue interface. Here, we have focused on the role of pro-inflammatory reactive oxygen species. Specifically, adult rats implanted within intracortical microelectrodes were systemically administered the anti-oxidant, resveratrol, both the day before and the day of surgery. Animals were sacrificed at two or four weeks post-implantation for histological analysis of the neuroinflammatory and neurodegenerative responses to the microelectrode. At two weeks post-implantation, we found animals treated with resveratrol demonstrated suppression of reactive oxygen species accumulation and blood-brain barrier instability, accompanied with increased density of neurons at the intracortical microelectrode-tissue interface. Four weeks post-implantation, animals treated with resveratrol exhibited indistinguishable levels of markers for reactive oxygen species and neuronal nuclei density in comparison to untreated control animals. However, of the neurons that remained, resveratrol treated animals were seen to display reductions in the density of degenerative neurons compared to control animals at both two and four weeks post-implantation. Initial mechanistic evaluation suggested the roles of both anti-oxidative enzymes and toll-like receptor 4 expression in facilitating microglia activation and the propagation of neurodegenerative inflammatory pathways. Collectively, our data suggests that short-term attenuation of reactive oxygen species accumulation and blood-brain barrier instability can result in prolonged improvements in neuronal viability around implanted intracortical microelectrodes, while also identifying potential therapeutic targets to reduce chronic intracortical microelectrode-mediated neurodegeneration.

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Resveratrol inhibits neuroinflammation.
“Resveratrol has been shown to exert an inhibitory activity on neuroinflammation in several studies (Candelario-Jalil et al., 2007; Lu et al., 2010; Potter et al., 2013; Zhang R et al., 2013; Wang et al., 2015)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Potter et al., 2013

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Potter, K. A. (2014) · OhioLink ETD Center (Ohio Library and Information Network)
Resveratrol Delivery from Implanted Cyclodextrin Polymers Provides Sustained Antioxidant Effect on Implanted Neural Probes
Haley, R. M., Zuckerman, S. T., Dakhlallah, H., Capadona, J. R., von Recum, H. A., & Ereifej, E. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103579 · Cited by 32 · see citing works

Authors: Potter, K. A., Buck, A. C., Self, W. K., Callanan, M. E., Sunil, S., & Capadona, J. R.
Affiliations: Louis Stokes Cleveland VA Medical Center (US)
Case Western Reserve University (US)
Corresponding author: Capadona, Jeffrey R.
ORCID: Self, Wade K.
Sunil, Smrithi
Capadona, Jeffrey R.
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2013-09
Volume: 34
Issue: 29
Pages: 7001-7015
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2013.05.035
OpenAlex: W2072832306
Cited by: 129
References: 62
Citations by year: 2026: 1 · 2025: 7 · 2024: 7 · 2023: 13 · 2022: 9 · 2021: 11 · 2020: 12 · 2019: 5 · 2018: 20 · 2017: 11 · 2016: 8 · 2015: 6 · 2014: 16 · 2013: 3
FWCI: 5.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs (I01 RX001495)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: resveratrol, intracortical microelectrodes, neurodegeneration, neuroinflammation, reactive oxygen species, oxidative stress, neuronal viability, microglial activation, TLR4, antioxidant enzymes, neurodegeneration prevention
MeSH terms: Resveratrol, Animals, Antioxidants, Blood-Brain Barrier, Electrodes, Implanted, Male, Microelectrodes, Neurons, Stilbenes, Reactive Oxygen Species, Rats

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The Effect of Resveratrol on Neurodegeneration and Blood Brain Barrier Stability Surrounding Intracortical Microelectrodes

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