The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
PCNA binding proteins
Open accessAbstract
PCNA (proliferating cell nuclear antigen), originally characterized as a DNA polymerase accessory protein, functions as a DNA sliding clamp for DNA polymerase delta and is an essential component for eukaryotic chromosomal DNA replication. Recent studies have revealed a striking feature of PCNA in its ability to interact with multiple partners, involved, for example, in Okazaki fragment joining, DNA repair, DNA methylation and chromatin assembly. Since these reactions take place mainly on replicating DNA, PCNA has applications as a marker for DNA synthesis. It is of interest that proteins involved in cell cycle regulation may also exhibit PCNA binding activity. For example, the CDK inhibitor, p21 (Cip1/Waf1) interacts with PCNA blocking its activity necessary for DNA replication and also affecting interactions with other PCNA binding proteins. The available data indicate that DNA sliding clamps have generated additional functions with evolution of eukaryotes from simple prokaryotes. In mammalian cells, they play key roles in controlling DNA synthesis reactions and the reorganization of replicated DNA at replication forks. Several cell cycle regulation proteins target these processes by affecting PCNA actions
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Citations
Cites
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
Waga, S., Hannon, G. J., Beach, D., & Stillman, B. (1994) · Nature · doi:10.1038/369574a0 · Cited by 1,655
Mammalian DNA nucleotide excision repair reconstituted with purified protein components
Aboussekhra, A., Biggerstaff, M., Shivji, M. K. K., Vilpo, J. A., Moncollin, V., Podust, V. N., Protić, M., Hübscher, U., Egly, J.-M., & Wood, R. D. (1995) · Cell · doi:10.1016/0092-8674(95)90289-9 · Cited by 837
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
Chen, J., Jackson, P. K., Kirschner, M. W., & Dutta, A. (1995) · Nature · doi:10.1038/374386a0 · Cited by 548
Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts
Pagano, M., Theodoras, A. M., Tam, S. W., & Draetta, G. F. (1994) · Genes & Development · doi:10.1101/gad.8.14.1627 · Cited by 294
Li, X., Li, J., Harrington, J., Lieber, M. R., & Burgers, P. M. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.38.22109 · Cited by 276
Fortini, P., Pascucci, B., Parlanti, E., Sobol, R. W., Wilson, S. H., & Dogliotti, E. (1998) · Biochemistry · doi:10.1021/bi972999h · Cited by 232
Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21
Pan, Z.-Q., Reardon, J. T., Li, L., Flores-Rozas, H., Legerski, R., Sancar, A., & Hurwitz, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.37.22008 · Cited by 151
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Nakanishi, M., Robetorye, R. S., Pereira-Smith, O. M., & Smith, J. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17060 · Cited by 92
Oku, T., Ikeda, S., Sasaki, H., Fukuda, K., Morioka, H., Ohtsuka, E., Yoshikawa, H., & Tsurimoto, T. (1998) · Genes to Cells · doi:10.1046/j.1365-2443.1998.00199.x · Cited by 77
Self-citation
Cited by
Kunkel, T. A., & Erie, D. A. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133243 · Cited by 1,367
What a difference a decade makes: Insights into translesion DNA synthesis
Yang, W., & Woodgate, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704219104 · Cited by 379
PCNA Controls Establishment of Sister Chromatid Cohesion during S Phase
Moldovan, G.-L., Pfander, B., & Jentsch, S. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.07.007 · Cited by 282
Repair of Oxidative DNA Damage: Mechanisms and Functions
Lu, A.-L., Li, X., Gu, Y., Wright, P. M., & Chang, D.-Y. (2001) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:35:2:141 · Cited by 272
PBK/TOPK, a Proliferating Neural Progenitor-Specific Mitogen-Activated Protein Kinase Kinase
Dougherty, J. D., Garcia, A. D. R., Nakano, I., Livingstone, M., Norris, B., Polakiewicz, R., Wexler, E. M., Sofroniew, M. V., Kornblum, H. I., & Geschwind, D. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3207-05.2005 · Cited by 96
“This is supported by data showing that purified CGP in vitro expresses PBK/TOPK, which is mitogen dependent, parallel with the SSH requirement for CGP proliferation (Wechsler-Reya and Scott, 1999).”
BackgroundMethodInfluential
Metadata
- Authors
- Tsurimoto, T.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 1999
- Volume
- 4
- Issue
- 4
- Pages
- d849-858
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/a469
- OpenAlex
- W2019895813
- Cited by
- 213
- References
- 10
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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