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Cited by 204

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Regulation of mammalian ryanodine receptors

Open access
Meissner, Gerhard·2002·Frontiers in Bioscience

Abstract

Ryanodine receptors (RyRs) are large, high conductance Ca2+ channels that control the level of intracellular Ca2+ by releasing Ca2+ from an intracellular compartment, the sarco/endoplasmic reticulum. Mammalian tissues express 3 closely related ryanodine receptors (RyRs) known as skeletal muscle (RyR1), cardiac muscle (RyR2) and brain (RyR3). The RyRs are isolated as 30S protein complexes comprised of four 560 kDa RyR2 subunits and four 12.6 kDa FK506 binding protein (FKBP12.6) subunits. Multiple endogenous effector molecules and posttranslational modifications regulate the RyRs. This chapter reviews the regulation of the mammalian RyRs by endogenous effector molecules.

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Metadata

Authors
Meissner, G.
Venue
Frontiers in Bioscience
Publisher
IMR Press
Published
2002
Volume
7
Issue
4
Pages
d2072-2080
ISSN
  • 1093-4715 (ISSN-L)
  • 1093-9946
OpenAlex
W2075989491
Cited by
204
References
1
FWCI
4.64
Type
journal article
Language
en
Open access
bronze

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Meissner, G. (2002). Regulation of mammalian ryanodine receptors. Frontiers in Bioscience. https://doi.org/10.2741/a899

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