PCB-95 Promotes Dendritic Growth via Ryanodine Receptor–Dependent Mechanisms

Basic and Clinical Biostatistics,

(2002) · Survey of Ophthalmology · doi:10.1016/s0039-6257(02)00360-0 · Cited by 1,809 · see citing works

Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images

Meijering, E. H. W., Jacob, M., Sarria, J. ‐. F., Steiner, P., Hirling, H., & Unser, M. A. (2004) · Cytometry Part A · doi:10.1002/cyto.a.20022 · Cited by 1,611 · see citing works

Dendritic spine pathology in neuropsychiatric disorders

Penzes, P., Cahill, M. E., Jones, K. A., VanLeeuwen, J.-E., & Woolfrey, K. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2741 · Cited by 1,523 · see citing works

A synaptic trek to autism

Bourgeron, T. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.06.003 · Cited by 637 · cited 4× · see citing works

Calmodulin-kinases: modulators of neuronal development and plasticity.

Wayman, G. A., Lee, Y.-S., Tokumitsu, H., Silva, A., & Soderling, T. R. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.021 · Cited by 567 · see citing works

Calcium microdomains: Organization and function

Berridge, M. J. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.09.002 · Cited by 525 · see citing works

Effects of PCB exposure on neuropsychological function in children.

Schantz, S. L., Widholm, J. J., & Rice, D. C. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5461 · Cited by 503 · see citing works

Dendritic arbor development and synaptogenesis

Cline, H. T. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00182-3 · Cited by 499 · see citing works

Polychlorinated Biphenyls (PCBs): Routes of Exposure and Effects on Human Health

Carpenter, D. O. (2006) · Reviews on Environmental Health · doi:10.1515/reveh.2006.21.1.1 · Cited by 494 · see citing works

Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2

Wayman, G. A., Impey, S., Marks, D., Saneyoshi, T., Grant, W. F., Derkach, V., & Soderling, T. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.008 · Cited by 466 · cited 4× · see citing works

Calcium Regulation of Dendritic Growth via CaM Kinase IV and CREB-Mediated Transcription

Redmond, L., Kashani, A. H., & Ghosh, A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00737-7 · Cited by 462 · see citing works

BDNF Regulates the Translation of a Select Group of mRNAs by a Mammalian Target of Rapamycin-Phosphatidylinositol 3-Kinase-Dependent Pathway during Neuronal Development

Schratt, G. M., Nigh, E. A., Chen, W., Hu, L. S., & Greenberg, M. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1739-04.2004 · Cited by 401 · see citing works

INTRACELLULAR CALCIUM RELEASE AND CARDIAC DISEASE

Wehrens, X. H. T., Lehnart, S. E., & Marks, A. R. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.114521 · Cited by 356 · see citing works

How do dendrites take their shape?

Scott, E. K., & Luo, L. (2001) · Nature Neuroscience · doi:10.1038/86006 · Cited by 292 · see citing works

An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling

Impey, S., Davare, M., Lasiek, A., Fortin, D., Ando, H., Varlamova, O., Obrietan, K., Soderling, T. R., Goodman, R. H., & Wayman, G. A. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.10.005 · Cited by 270 · see citing works

Local Protein Synthesis Mediates a Rapid Increase in Dendritic Elongation Factor 1A after Induction of Late Long-Term Potentiation

Tsokas, P. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0599-05.2005 · Cited by 245 · see citing works

Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity

Pessah, I. N., Cherednichenko, G., & Lein, P. J. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.10.009 · Cited by 231 · see citing works

Delayed Maturation of Neuronal Architecture and Synaptogenesis in Cerebral Cortex of<i>Mecp2</i>-Deficient Mice

Fukuda, T., Itoh, M., Ichikawa, T., Washiyama, K., & Goto, Y.-I. (2005) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1093/jnen/64.6.537 · Cited by 221 · see citing works

Regulation of mammalian ryanodine receptors

Meissner, G. (2002) · Frontiers in bioscience · doi:10.2741/a899 · Cited by 204 · see citing works

Dendritic spine formation and pruning: common cellular mechanisms?

Segal, M., Korkotian, E., & Murphy, D. D. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01499-x · Cited by 196 · see citing works

Identification and localization of two triad junctional foot protein isoforms in mature avian fast twitch skeletal muscle.

Airey, J. A., Beck, C. F., Murakami, K., Tanksley, S. J., Deerinck, T. J., Ellisman, M. H., & Sutko, J. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77285-2 · Cited by 182 · see citing works

Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating

Samsó, M., Feng, W., Pessah, I. N., & Allen, P. D. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000085 · Cited by 180 · see citing works

Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats

Yang, D., Kim, K. H., Phimister, A., Bachstetter, A. D., Ward, T. R., Stackman, R. W., Mervis, R. F., Wisniewski, A. B., Klein, S. L., Kodavanti, P. R. S., et al. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.11771 · Cited by 166 · see citing works

When cortical development goes wrong: schizophrenia as a neurodevelopmental disease of microcircuits

Garey, L. J. (2010) · Journal of Anatomy · doi:10.1111/j.1469-7580.2010.01231.x · Cited by 154 · see citing works

Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration

Chen, Y., Tassone, F., Berman, R. F., Hagerman, P. J., Hagerman, R. J., Willemsen, R., & Pessah, I. N. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp479 · Cited by 151 · see citing works

Regulation of dendritic growth and plasticity by local and global calcium dynamics.

Lohmann, C., & Wong, R. O. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.01.008 · Cited by 146 · see citing works

Structure−Activity Relationship for Noncoplanar Polychlorinated Biphenyl Congeners toward the Ryanodine Receptor-Ca 2+ Channel Complex Type 1 (RyR1)

Pessah, I. N., Hansen, L. G., Albertson, T. E., Garner, C. E., Ta, T. A., Do, Z., Kim, K. H., & Wong, P. W. (2005) · Chemical Research in Toxicology · doi:10.1021/tx050196m · Cited by 145 · see citing works

Transmembrane Redox Sensor of Ryanodine Receptor Complex

Feng, W., Liu, G., Allen, P. D., & Pessah, I. N. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000523200 · Cited by 141 · see citing works

PCB-95 Modulates the Calcium-Dependent Signaling Pathway Responsible for Activity-Dependent Dendritic Growth

Wayman, G. A., Bose, D. D., Yang, D., Lesiak, A. J., Bruun, D. A., Impey, S., Ledoux, V. A., Pessah, I. N., & Lein, P. J. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104833 · Cited by 136 · see citing works

Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation

Adasme, T., Haeger, P. A., Paula-Lima, A. C., Espinoza, I., Casas-Alarcón, M. M., Carrasco, M. A., & Hidalgo, C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013580108 · Cited by 135 · see citing works

Regulation of spine and synapse formation by activity-dependent intracellular signaling pathways

Saneyoshi, T., Fortin, D. A., & Soderling, T. R. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.09.013 · Cited by 133 · see citing works

Ortho-substituted polychlorinated biphenyls Alter microsomal calcium transport by direct interaction with ryanodine receptors of mammalian brain*

Wong, P. W., Brackney, W. R., & Pessah, I. N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15145 · Cited by 124 · see citing works

Induction and maintenance of late‐phase long‐term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones

Vickers, C. A., Dickson, K. S., & Wyllie, D. J. A. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.092924 · Cited by 116 · see citing works

Ortho-substituted polychlorinated biphenyls alter calcium regulation by a ryanodine receptor-mediated mechanism: structural specificity toward skeletal- and cardiac-type microsomal calcium release channels.

WONG, P. W. K., & Pessah, I. N. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08790-5 · Cited by 116 · see citing works

Polychlorinated biphenyls, organochlorine pesticides and neurodevelopment

Korrick, S. A., & Sagiv, S. K. (2008) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3282f6a4e9 · Cited by 115 · see citing works

Long-term effects of developmental exposure to 2,2',3,5',6-pentachlorobiphenyl (PCB 95) on locomotor activity, spatial learning and memory and brain ryanodine binding.

Schantz, S. L., Seo, B. W., Wong, P. W., & Pessah, I. N. (1997) · PubMed · Cited by 114 · see citing works

Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor

Howard, A. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00156-x · Cited by 112 · see citing works

Molecular Mechanisms Involved in the Toxic Effects of Polychlorinated Biphenyls (PCBs) and Brominated Flame Retardants (BFRs)

Fonnum, F., Mariussen, E., & Reistad, T. (2005) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390500259020 · Cited by 109 · see citing works

Direct evidence for the existence and functional role of hyperreactive sulfhydryls on the ryanodine receptor-triadin complex selectively labeled by the coumarin maleimide 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin.

Liu, G., Abramson, J. J., Zable, A. C., & Pessah, I. N. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09914-6 · Cited by 103 · see citing works

Differential Effects of Two Lots of Aroclor 1254: Congener-Specific Analysis and Neurochemical End Points

Kodavanti, P. R. S., Kannan, N., Yamashita, N., Derr-Yellin, E. C., Ward, T. R., Burgin, D. E., Tilson, H. A., & Birnbaum, L. S. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.011091153 · Cited by 97 · see citing works

Polychlorinated Biphenyls 105 and 118 Form Thyroid Hormone Receptor Agonists after Cytochrome P4501A1 Activation in Rat Pituitary GH3 Cells

Gauger, K. J., Giera, S., Sharlin, D. S., Bansal, R., Iannacone, E. A., & Zoeller, R. T. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10328 · Cited by 95 · see citing works

Expression of a cardiac Ca2+-release channel isoform in mammalian brain

Lai, F. A., Dent, M. A. R., Wickenden, C., Xu, L., Kumari, G., Misra, M., Lee, H. B., Sar, M., & Meissner, G. (1992) · Biochemical Journal · doi:10.1042/bj2880553 · Cited by 93 · see citing works

Functional Interaction of Neuronal Cav1.3 L-type Calcium Channel with Ryanodine Receptor Type 2 in the Rat Hippocampus

Kim, S., Yun, H., Baik, J., Chung, K. C., Nah, S.-Y., & Rhim, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701418200 · Cited by 90 · see citing works

Individual Polychlorinated Biphenyl (PCB) Congeners Produce Tissue- and Gene-Specific Effects on Thyroid Hormone Signaling during Development

Giera, S., Bansal, R., Ortiz-Toro, T., Taub, D. G., & Zoeller, R. T. (2011) · Endocrinology · doi:10.1210/en.2010-1490 · Cited by 89 · see citing works

Formulation and Characterization of an Experimental PCB Mixture Designed to Mimic Human Exposure from Contaminated Fish

Kostyniak, P. J., Hansen, L. G., Widholm, J. J., Fitzpatrick, R. D., Olson, J. R., Helferich, J. L., Kim, K. H., Sable, H. J. K., Seegal, R. F., Pessah, I. N., et al. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi338 · Cited by 88 · see citing works

Ontogenetic Alterations in Molecular and Structural Correlates of Dendritic Growth after Developmental Exposure to Polychlorinated Biphenyls

Lein, P. J., Yang, D., Bachstetter, A. D., Tilson, H. A., Harry, G. J., Mervis, R. F., & Kodavanti, P. R. S. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9773 · Cited by 81 · see citing works

Acute Hippocampal Slice Preparation and Hippocampal Slice Cultures

Lein, P. J., Barnhart, C. D., & Pessah, I. N. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-170-3_8 · Cited by 80 · see citing works

Mice expressing T4826I‐RYR1 are viable but exhibit sex‐ and genotype‐dependent susceptibility to malignant hyperthermia and muscle damage

Yuen, B., Boncompagni, S., Feng, W., Yang, T., Lopez, J. R., MATTHAEI, K. I., Goth, S. R., Protasi, F., Franzini‐Armstrong, C., Allen, P. D., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-197582 · Cited by 80 · see citing works

Properties of Ryr3 Ryanodine Receptor Isoform in Mammalian Brain

Murayama, T., & Ogawa, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.5079 · Cited by 74 · see citing works

Redox sensing properties of the Ryanodine receptor complex

Pessah, I. N. (2002) · Frontiers in bioscience · doi:10.2741/a741 · Cited by 72 · see citing works

Neuronal structural remodeling: is it all about access?

Chen, J. L., & Nedivi, E. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.06.002 · Cited by 68 · see citing works

Regulation of the Postsynaptic Cytoskeleton: Roles in Development, Plasticity, and Disorders

Svitkina, T., Lin, W., Webb, D. J., Yasuda, R., Wayman, G. A., Aelst, L. V., & Soderling, S. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4276-10.2010 · Cited by 63 · see citing works

Mechanisms of Dendritic Maturation

Libersat, F., & Duch, C. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:3:303 · Cited by 55 · see citing works

Complex Pharmacology of Malignant Hyperthermia

Pessah, I. N., Lynch, C. I., & Gronert, G. A. (1996) · Anesthesiology · doi:10.1097/00000542-199606000-00001 · Cited by 52 · see citing works

Genes, exercise and sudden death: molecular basis of familial catecholaminergic polymorphic ventricular tachycardia

Laitinen, P. H., Swan, H., Piippo, K., Viitasalo, M. T., Toivonen, L. K., & KONTULA, K. K. (2004) · Annals of Medicine · doi:10.1080/17431380410032599 · Cited by 42 · see citing works

Discrimination of multiple binding sites for antagonists of the calcium release channel complex of skeletal and cardiac sarcoplasmic reticulum.

Mack, W., Zimanyi, I. A., & Pessah, I. N. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10895-1 · Cited by 40 · see citing works

Gene Dose Influences Cellular and Calcium Channel Dysregulation in Heterozygous and Homozygous T4826I-RYR1 Malignant Hyperthermia-susceptible Muscle

Barrientos, G. C., Feng, W., Truong, K. M., MATTHAEI, K. I., Yang, T., Allen, P. D., Lopez, J. R., & Pessah, I. N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.307926 · Cited by 34 · see citing works

Inhibition of rapid Ca-release from isolated skeletal and cardiac sarcoplasmic reticulum (SR) membranes

Chiesi, M., Schwaller, R., & Calviello, G. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(88)90641-9 · Cited by 27 · see citing works

Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95)

Ta, T. A., & Pessah, I. N. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.08.007 · Cited by 23 · see citing works

Neurotoxicity of polychlorinated biphenyls and related organohalogens

Pessah, I. N., Lein, P. J., Seegal, R. F., & Sagiv, S. K. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01978-1 · Cited by 222 · see citing works

Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11‐q13 duplication autism spectrum disorder

Mitchell, M. M., Woods, R., Chi, L., Schmidt, R. J., Pessah, I. N., Kostyniak, P. J., & LaSalle, J. M. (2012) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21722 · Cited by 164 · see citing works

DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?

Keil, K. P., & Lein, P. J. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvv012 · Cited by 167 · see citing works

PCB-95 Modulates the Calcium-Dependent Signaling Pathway Responsible for Activity-Dependent Dendritic Growth

Wayman, G. A., Bose, D. D., Yang, D., Lesiak, A. J., Bruun, D. A., Impey, S., Ledoux, V. A., Pessah, I. N., & Lein, P. J. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104833 · Cited by 136 · see citing works

Evidence Implicating Non-Dioxin-Like Congeners as the Key Mediators of Polychlorinated Biphenyl (PCB) Developmental Neurotoxicity

Klocke, C. R., & Lein, P. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031013 · Cited by 135 · see citing works

Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders

Stamou, M., Streifel, K. M., Goines, P. E., & Lein, P. J. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.12.001 · Cited by 128 · see citing works

Is Triclosan a neurotoxic agent?

Ruszkiewicz, J. A., Li, S., Rodriguez, M. B., & Aschner, M. (2017) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2017.1281181 · Cited by 121 · see citing works

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

Bal‐Price, A., Lein, P. J., Keil, K. P., Sethi, S., Shafer, T. J., Barenys, M., Fritsche, E., Sachana, M., & Meek, M. E. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.05.010 · Cited by 96 · see citing works

Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor

Sethi, S., Morgan, R. K., Feng, W., Lin, Y., Li, X., Luna, C., Koch, M., Bansal, R., Duffel, M. W., Puschner, B., et al. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b00535 · Cited by 90 · see citing works

Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery

Zimmer, B., Pallocca, G., Dreser, N., Foerster, S., Waldmann, T., Westerhout, J., Julien, S., Krause, K., van Thriel, C., Hengstler, J. G., et al. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1231-9 · Cited by 86 · see citing works

Persistent organic pollutants distribution in lipoprotein fractions in relation to cardiovascular disease and cancer

Ljunggren, S., Helmfrid, I., Salihović, S., van Bavel, B., Wingren, G. B., Lindahl, M., & Karlsson, H. (2014) · Environment International · doi:10.1016/j.envint.2013.12.017 · Cited by 86 · see citing works

The Environmental Neurotoxicant PCB 95 Promotes Synaptogenesis via Ryanodine Receptor-Dependent miR132 Upregulation

Lesiak, A., Zhu, M., Chen, H., Appleyard, S. M., Impey, S., Lein, P. J., & Wayman, G. A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2884-13.2014 · Cited by 85 · see citing works

Triclosan Impairs Swimming Behavior and Alters Expression of Excitation-Contraction Coupling Proteins in Fathead Minnow (Pimephales promelas)

Holland, E. B., Connon, R. E., Werner, I., Davies, R. E., Beggel, S., Feng, W., & Pessah, I. N. (2013) · Environmental Science & Technology · doi:10.1021/es303790b · Cited by 85 · see citing works

The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences

Klocke, C. R., Sethi, S., & Lein, P. J. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-06723-5 · Cited by 83 · see citing works

Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure

Laufer, B. I., Neier, K. E., Valenzuela, A. E., Yasui, D. H., Schmidt, R. J., Lein, P. J., & LaSalle, J. M. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110442 · Cited by 72 · see citing works

Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes

Dunaway, K. W., Islam, M. S., Coulson, R. L., Lopez, S. J., Ciernia, A. V., Chu, R. G., Yasui, D. H., Pessah, I. N., Lott, P. C., Mordaunt, C. E., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.058 · Cited by 68 · see citing works

Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder?

Panesar, H. K., Kennedy, C., Keil, K. P., & Lein, P. J. (2020) · Toxics · doi:10.3390/toxics8030070 · Cited by 70 · see citing works

PCB 136 Atropselectively Alters Morphometric and Functional Parameters of Neuronal Connectivity in Cultured Rat Hippocampal Neurons via Ryanodine Receptor-Dependent Mechanisms

Yang, D., Kania‐Korwel, I., Ghogha, A., Chen, H., Stamou, M., Bose, D. D., Pessah, I. N., Lehmler, H., & Lein, P. J. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kft334 · Cited by 71 · see citing works

Nonlegacy PCBs: Pigment Manufacturing By-Products Get a Second Look

Grossman, E. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.121-a86 · Cited by 70 · see citing works

Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice

Rude, K. M., Pusceddu, M. M., Keogh, C. E., Sladek, J. A., Rabasa, G., Miller, E. N., Sethi, S., Keil, K. P., Pessah, I. N., Lein, P. J., et al. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.07.066 · Cited by 67 · see citing works

Detection of 3,3′-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons

Sethi, S., Keil, K. P., Chen, H., Hayakawa, K. A., Li, X., Lin, Y., Lehmler, H., Puschner, B., & Lein, P. J. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx100 · Cited by 63 · see citing works

Nanotechnology: new opportunities for the development of patch‐clamps

Gao, J., Liao, C., Liu, S., Xia, T., & Jiang, G. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00841-4 · Cited by 62 · see citing works

2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) and Its Hydroxylated Metabolites Are Enantiomerically Enriched in Female Mice

Kania‐Korwel, I., Barnhart, C. D., Stamou, M., Truong, K. M., Elkomy, M. H., Lein, P. J., Veng‐Pedersen, P., & Lehmler, H. (2012) · Environmental Science & Technology · doi:10.1021/es302810t · Cited by 62 · see citing works

Exposure to endocrine disrupting chemicals and neurodevelopmental alterations

Pinson, A., Bourguignon, J. P., & Parent, A. (2016) · Andrology · doi:10.1111/andr.12211 · Cited by 62 · see citing works

Long-term dietary-exposure to non-coplanar PCBs induces behavioral disruptions in adult zebrafish and their offspring

Péan, S., Daouk, T., Vignet, C., Lyphout, L., Leguay, D., Loizeau, V., Bégout, M., & Cousin, X. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.07.001 · Cited by 56 · see citing works

In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons

Keil, K. P., Sethi, S., Wilson, M., Chen, H., & Lein, P. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-08459-z · Cited by 56 · see citing works

Molecular and functional identification of a mitochondrial ryanodine receptor in neurons

Jakob, R., Beutner, G., Sharma, V. K., Duan, Y., Gross, R. A., Hurst, S., Jhun, B. S., O‐Uchi, J., & Sheu, S. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.05.026 · Cited by 52 · see citing works

Developmental exposure to environmentally relevant concentrations of bifenthrin alters transcription of mTOR and ryanodine receptor-dependent signaling molecules and impairs predator avoidance behavior across early life stages in inland silversides (Menidia beryllina)

Frank, D. F., Brander, S. M., Hasenbein, S., Harvey, D. J., Lein, P. J., Geist, J. P., & Connon, R. E. (2018) · Aquatic Toxicology · doi:10.1016/j.aquatox.2018.10.014 · Cited by 52 · see citing works

Polychlorinated biphenyls influence on autism spectrum disorder risk in the MARBLES cohort

Granillo, L., Sethi, S., Keil, K. P., Lin, Y., Ozonoff, S. J., Iosif, A., Puschner, B., & Schmidt, R. J. (2018) · Environmental Research · doi:10.1016/j.envres.2018.12.061 · Cited by 51 · see citing works

Glutamate drugs and pharmacogenetics of OCD: a pathway-based exploratory approach

Grados, M. A., Specht, M. W., Sung, H.-M., & Fortune, D. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.845553 · Cited by 49 · see citing works

Obesity, Persistent Organic Pollutants and Related Health Problems

Vassilopoulou, L., Psycharakis, C., Petrakis, D., Tsiaoussis, J., & Tsatsakis, A. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_4 · Cited by 47 · see citing works

Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio)

Frank, D. F., Miller, G. W., Harvey, D. J., Brander, S. M., Geist, J. P., Connon, R. E., & Lein, P. J. (2018) · Aquatic Toxicology · doi:10.1016/j.aquatox.2018.04.003 · Cited by 47 · see citing works

Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disorder insights

Laufer, B. I., Hwang, H., Ciernia, A. V., Mordaunt, C. E., & LaSalle, J. M. (2019) · Epigenetics · doi:10.1080/15592294.2019.1609867 · Cited by 47 · see citing works

The effect of the aquatic contaminants bisphenol-A and PCB-95 on the zebrafish lateral line

Hayashi, L., Sheth, M., Young, A. P., Kruger, M., Wayman, G. A., & Coffin, A. B. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.12.010 · Cited by 45 · see citing works

An Extended Structure–Activity Relationship of Nondioxin-Like PCBs Evaluates and Supports Modeling Predictions and Identifies Picomolar Potency of PCB 202 Towards Ryanodine Receptors

Holland, E. B., Feng, W., Zheng, J., Dong, Y., Li, X., Lehmler, H., & Pessah, I. N. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw189 · Cited by 45 · see citing works

Linoleic acid‐derived metabolites constitute the majority of oxylipins in the rat pup brain and stimulate axonal growth in primary rat cortical neuron‐glia co‐cultures in a sex‐dependent manner

Hennebelle, M., Morgan, R. K., Sethi, S., Zhang, Z., Chen, H., Grodzki, A. C., Lein, P. J., & Taha, A. Y. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14818 · Cited by 44 · see citing works

Developmental Exposure to a Human-Relevant Polychlorinated Biphenyl Mixture Causes Behavioral Phenotypes That Vary by Sex and Genotype in Juvenile Mice Expressing Human Mutations That Modulate Neuronal Calcium

Sethi, S., Keil, K. P., Valenzuela, A. E., Klocke, C. R., Silverman, J. L., Puschner, B., Pessah, I. N., & Lein, P. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.766826 · Cited by 43 · see citing works

Assessment of Polychlorinated Biphenyls and Their Hydroxylated Metabolites in Postmortem Human Brain Samples: Age and Brain Region Differences

Li, X., Hefti, M. M., Marek, R. F., Hornbuckle, K. C., Wang, K., & Lehmler, H. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c00581 · Cited by 43 · see citing works

A review on structural mechanisms of protein-persistent organic pollutant (POP) interactions

Nagar, N., Saxena, H., Pathak, A., Mishra, A., & Poluri, K. M. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138877 · Cited by 43 · see citing works

Simultaneous determination of polybrominated diphenyl ethers and polychlorinated biphenyls by gas chromatography–tandem mass spectrometry in human serum and plasma

Lin, Y.-P., Pessah, I. N., & Puschner, B. (2013) · Talanta · doi:10.1016/j.talanta.2013.04.001 · Cited by 43 · see citing works

Structure-Activity Relationship of Selected Meta- and Para-Hydroxylated Non–Dioxin Like Polychlorinated Biphenyls: From Single RyR1 Channels to Muscle Dysfunction

Niknam, Y., Feng, W., Cherednichenko, G., Dong, Y., Joshi, S. N., Vyas, S. M., Lehmler, H., & Pessah, I. N. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft202 · Cited by 43 · see citing works

Enantioselectivity of 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) Atropisomers toward Ryanodine Receptors (RyRs) and Their Influences on Hippocampal Neuronal Networks

Feng, W., Zheng, J., Robin, G., Dong, Y., Ichikawa, M., Inoue, Y., Mori, T., Nakano, T., & Pessah, I. N. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b04446 · Cited by 42 · see citing works

Metabolism of 2,2′,3,3′,6,6′-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent

Wu, X., Kania‐Korwel, I., Chen, H., Stamou, M., Dammanahalli, K. J., Duffel, M. W., Lein, P. J., & Lehmler, H. (2013) · Xenobiotica · doi:10.3109/00498254.2013.785626 · Cited by 40 · see citing works

Oxidation of Polychlorinated Biphenyls by Liver Tissue Slices from Phenobarbital-Pretreated Mice Is Congener-Specific and Atropselective

Wu, X., Duffel, M. W., & Lehmler, H. (2013) · Chemical Research in Toxicology · doi:10.1021/tx400229e · Cited by 40 · see citing works

Restoration of Physiological Expression of 5-HT6 Receptor into the Primary Cilia of Null Mutant Neurons Lengthens Both Primary Cilia and Dendrites

Lesiak, A. J., Brodsky, M., Cohenca, N., Croicu, A. G., & Neumaier, J. F. (2018) · Molecular Pharmacology · doi:10.1124/mol.117.111583 · Cited by 37 · see citing works

Circulating levels of persistent organic pollutants (POPs) are associated with left ventricular systolic and diastolic dysfunction in the elderly

Lind, Y. S., Lind, P., Salihović, S., van Bavel, B., & Lind, L. (2013) · Environmental Research · doi:10.1016/j.envres.2013.02.007 · Cited by 37 · see citing works

Gene × environment interactions in autism spectrum disorders

Keil, K. P., & Lein, P. J. (2022) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2022.11.001 · Cited by 37 · see citing works

Autism and EMF? Plausibility of a pathophysiological link – Part I

Herbert, M. R., & Sage, C. (2013) · Pathophysiology · doi:10.1016/j.pathophys.2013.08.001 · Cited by 35 · see citing works

Changes in thyroid hormone activity disrupt photomotor behavior of larval zebrafish

Walter, K. M., Miller, G. W., Chen, X., Harvey, D. J., Puschner, B., & Lein, P. J. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.05.008 · Cited by 35 · see citing works

Editor’s Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity

Kania‐Korwel, I., Lukasiewicz, T., Barnhart, C. D., Stamou, M., Chung, H., Kelly, K. M., Bandiera, S. M., Lein, P. J., & Lehmler, H. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx071 · Cited by 34 · see citing works

Persistent organic pollutants at the synapse: Shared phenotypes and converging mechanisms of developmental neurotoxicity

Latchney, S. E., & Majewska, A. K. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22825 · Cited by 32 · see citing works

3,3ʹ-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism

Sethi, S., Keil, K. P., & Lein, P. J. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2307-8 · Cited by 31 · see citing works

Structure–activity relationship of non-coplanar polychlorinated biphenyls toward skeletal muscle ryanodine receptors in rainbow trout (Oncorhynchus mykiss)

Holland, E. B., & Pessah, I. N. (2013) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.06.003 · Cited by 31 · see citing works

BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms

Chen, H., Streifel, K. M., Singh, V., Yang, D., Mangini, L., Wulff, H., & Lein, P. J. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw259 · Cited by 30 · see citing works

Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory

Hiess, F., Yao, J., Song, Z., Sun, B., Zhang, Z., Huang, J., Chen, L., Institóris, Á., Estillore, J. P., Wang, R., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03124-2 · Cited by 29 · see citing works

Influence of Nanomolar Deltamethrin on the Hallmarks of Primary Cultured Cortical Neuronal Network and the Role of Ryanodine Receptors

Zheng, J., Yu, Y., Feng, W., Li, J., Ju, L., Zhang, C., Dong, Y., Pessah, I. N., & Cao, Z. (2019) · Environmental Health Perspectives · doi:10.1289/ehp4583 · Cited by 27 · see citing works

Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells

Ohashi, R., Sakata, S., Naito, A., Hirashima, N., & Tanaka, M. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22139 · Cited by 27 · see citing works

Persistent organic pollutants in green sea turtles (Chelonia mydas) inhabiting two urbanized Southern California habitats

Barraza, A. D., Komoroske, L. M., Allen, C. D., Eguchi, T., Gossett, R., Holland, E. B., Lawson, D. D., LeRoux, R. A., Lorenzi, V., Seminoff, J. A., et al. (2020) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2020.110979 · Cited by 27 · see citing works

Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA

Holland, E. B., Stegeman, J. J., Goldstone, J. V., Nacci, D. E., Champlin, D. M., Jayaraman, S., Connon, R. E., & Pessah, I. N. (2014) · Aquatic Toxicology · doi:10.1016/j.aquatox.2014.12.017 · Cited by 26 · see citing works

Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity

Miller, G. W., Chandrasekaran, V., Yaghoobi, B., & Lein, P. J. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.04.016 · Cited by 26 · see citing works

Differential inhibitory effects of resveratrol on excitotoxicity and synaptic plasticity: involvement of NMDA receptor subtypes

Hsieh, C.-P., Chang, W.-T., Chen, L., Chen, H., & Chan, M. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1641995 · Cited by 26 · see citing works

Environmental Factors in the Onset of Autism Spectrum Disorder

Persico, A. M., & Merelli, S. (2014) · Current Developmental Disorders Reports · doi:10.1007/s40474-013-0002-2 · Cited by 25 · see citing works

Effect of Pregnancy on the Disposition of 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) Atropisomers and Their Hydroxylated Metabolites in Female Mice

Kania‐Korwel, I., Barnhart, C. D., Lein, P. J., & Lehmler, H. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00241 · Cited by 26 · see citing works

PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms

Keil, K. P., Miller, G. W., Chen, H., Sethi, S., Schmuck, M. R., Dhakal, K., Kim, J. W., & Lein, P. J. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2285-x · Cited by 26 · see citing works

Sex-Dependent Effects of 2,2′,3,5′,6-Pentachlorobiphenyl on Dendritic Arborization of Primary Mouse Neurons

Keil, K. P., Sethi, S., & Lein, P. J. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy277 · Cited by 25 · see citing works

Embryonic Exposure to 2,2′,3,5′,6-pentachlorobiphenyl (PCB-95) Causes Developmental Malformations in Zebrafish

Ranasinghe, P., Thorn, R. J., Seto, R. J., Créton, R., Bridges, W. C., Chapman, S. C., & Lee, C. M. (2019) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4587 · Cited by 23 · see citing works

Fatty liver and impaired hepatic metabolism alter the congener-specific distribution of polychlorinated biphenyls (PCBs) in mice with a liver-specific deletion of cytochrome P450 reductase

Li, X., Zhang, C., Wang, K., & Lehmler, H. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115233 · Cited by 23 · see citing works

Sex and Genotype Modulate the Dendritic Effects of Developmental Exposure to a Human-Relevant Polychlorinated Biphenyls Mixture in the Juvenile Mouse

Keil, K. P., Sethi, S., Klocke, C. R., de Ruyter, T. E., Wilson, M., Pessah, I. N., & Lein, P. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.766802 · Cited by 23 · see citing works

Human Liver Microsomes Atropselectively Metabolize 2,2′,3,4′,6-Pentachlorobiphenyl (PCB 91) to a 1,2-Shift Product as the Major Metabolite

Uwimana, E., Li, X., & Lehmler, H. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b00612 · Cited by 23 · see citing works

Application of electrophysiological technique in toxicological study: From manual to automated patch-clamp recording

Gao, J., Zhang, H., Xiong, P., Yan, X., Liao, C., & Jiang, G. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116082 · Cited by 22 · see citing works

Assigning atropisomer elution orders using atropisomerically enriched polychlorinated biphenyl fractions generated by microsomal metabolism

Kania‐Korwel, I., & Lehmler, H. (2012) · Journal of Chromatography A · doi:10.1016/j.chroma.2012.12.041 · Cited by 22 · see citing works

Lactational exposure to low levels of the six indicator non-dioxin-like polychlorinated biphenyls induces DNA damage and repression of neuronal activity, in juvenile male mice

Elnar, A. A., Desor, F., Marin, F., Soulimani, R., & Némos, C. (2014) · Toxicology · doi:10.1016/j.tox.2014.12.011 · Cited by 21 · see citing works

Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review)

Wang, Y., Hu, C., Fang, T., Jin, Y., & Wu, R. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4983 · Cited by 20 · see citing works

Identification of a novel hydroxylated metabolite of 2,2′,3,5′,6-pentachlorobiphenyl formed in whole poplar plants

Ma, C., Zhai, G., Wu, H., Kania‐Korwel, I., Lehmler, H., & Schnoor, J. L. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-5939-8 · Cited by 19 · see citing works

Gestational PCB52 exposure induces hepatotoxicity and intestinal injury by activating inflammation in dam and offspring mice: A maternal and progeny study

Xu, L., Zhang, Q.-Y., Chen, Y.-K., Chen, L., Zhang, K., Wang, Q., & Xie, X. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120186 · Cited by 18 · see citing works

Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice

Keil, K. P., Sethi, S., Wilson, M., Silverman, J. L., Pessah, I. N., & Lein, P. J. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12526 · Cited by 18 · see citing works

Ryanodine receptor-active non-dioxin-like polychlorinated biphenyls cause neurobehavioral deficits in larval zebrafish

Yaghoobi, B., Miller, G. W., Holland, E. B., Li, X., Harvey, D. J., Li, S., Lehmler, H., Pessah, I. N., & Lein, P. J. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.947795 · Cited by 17 · see citing works

Non-dioxin-like polychlorinated biphenyl neurotoxic equivalents found in environmental and human samples

Holland, E. B., & Pessah, I. N. (2020) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2020.104842 · Cited by 17 · see citing works

Environmental Factors in the Preconception and Prenatal Periods in Relation to Risk for ASD

Lyall, K., Schmidt, R. J., & Hertz‐Picciotto, I. (2014) · Wiley eBooks · doi:10.1002/9781118911389.hautc18 · Cited by 17 · see citing works

Atropselective Oxidation of 2,2′,3,3′,4,6′-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity

Uwimana, E., Cagle, B. S., Yeung, C., Li, X., Patterson, E. V., Doorn, J. A., & Lehmler, H. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz150 · Cited by 16 · see citing works

Toxicokinetics of Chiral PCB 136 and Its Hydroxylated Metabolites in Mice with a Liver-Specific Deletion of Cytochrome P450 Reductase

Li, X., Wu, X., Kelly, K. M., Veng‐Pedersen, P., & Lehmler, H. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00389 · Cited by 16 · see citing works

Polychlorinated biphenyls reduce the kinematics contractile properties of embryonic stem cells-derived cardiomyocytes by disrupting their intracellular Ca2+ dynamics

Rebuzzini, P., Zuccolo, E., Civello, C., Fassina, L., Aréchaga, J., Izquierdo, A., Faris, P. S., Zuccotti, M., Moccia, F. D., & Garagna, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-36333-z · Cited by 15 · see citing works

Molecular insights into PCB neurotoxicity: Comparing transcriptomic responses across dopaminergic neurons, population blood cells, and Parkinson's disease pathology

Krauskopf, J., Eggermont, K., Caiment, F., Verfaillie, C. M., & de Kok, T. M. C. M. (2024) · Environment International · doi:10.1016/j.envint.2024.108642 · Cited by 14 · see citing works

In utero and lactational PCB exposure drives anatomic changes in the juvenile mouse bladder

Keil, K. P., Kennedy, C., Sethi, S., Valenzuela, A. E., Nunez, A., Wang, K., Wang, Z., Wang, P., Spiegelhoff, A., Puschner, B., et al. (2021) · Current Research in Toxicology · doi:10.1016/j.crtox.2021.01.002 · Cited by 14 · see citing works

Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison

Holland, E. B., Goldstone, J. V., Pessah, I. N., Whitehead, A., Reid, N. M., Karchner, S. I., Hahn, M. E., Nacci, D. E., Clark, B. W., & Stegeman, J. J. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.09.002 · Cited by 14 · see citing works

Polyurethane Foam Emission Samplers to Identify Sources of Airborne Polychlorinated Biphenyls from Glass-Block Windows and Other Room Surfaces in a Vermont School

Hua, J. B. X., Marek, R. F., & Hornbuckle, K. C. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c05195 · Cited by 13 · see citing works

Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlorinated Biphenyls in Animal Samples

Zhang, C., Li, X., Keil, K. P., Sethi, S., Yang, W., Marek, R. F., Ding, X., Lein, P. J., Hornbuckle, K. C., & Lehmler, H. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c02027 · Cited by 13 · see citing works

Assessing CaMPARI as new approach methodology for evaluating neurotoxicity

Biechele-Speziale, D., Camarillo, M., Martin, N. R., Biechele-Speziale, J., Lein, P. J., & Plavicki, J. S. (2023) · NeuroToxicology · doi:10.1016/j.neuro.2023.05.013 · Cited by 11 · see citing works

Developmental exposure to polychlorinated biphenyls reduces amphetamine behavioral sensitization in Long–Evans rats

Poon, E., Monaikul, S., Kostyniak, P. J., Har, L., Schantz, S. L., & Sable, H. J. K. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.04.005 · Cited by 11 · see citing works

Automated high content image analysis of dendritic arborization in primary mouse hippocampal and rat cortical neurons in culture

Schmuck, M. R., Keil, K. P., Sethi, S., Morgan, R. K., & Lein, P. J. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2020.108793 · Cited by 11 · see citing works

Developmental polychlorinated biphenyl (PCB) exposure alters voiding physiology in young adult male and female mice.

Kennedy, C., Spiegelhoff, A., Lavery, T., Wang, K., Manuel, R. S. J., Wang, Z., Wildermuth, H., & Keil, K. P. (2022) · PubMed Central · Cited by 11 · see citing works

Primary cortical cell tri-culture to study effects of amyloid-β on microglia function and neuroinflammatory response

Kim, H., Le, B., Goshi, N., Zhu, K., Grodzki, A. C., Lein, P. J., Zhao, M., & Şeker, E. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241291142 · Cited by 11 · see citing works

Triiodothyronine or Antioxidants Block the Inhibitory Effects of BDE-47 and BDE-49 on Axonal Growth in Rat Hippocampal Neuron-Glia Co-Cultures

Chen, H., Carty, R., Bautista, A. C., Hayakawa, K. A., & Lein, P. J. (2022) · Toxics · doi:10.3390/toxics10020092 · Cited by 9 · see citing works

Developmental polychlorinated biphenyl exposure influences adult zebra finch reproductive behaviour

DeLeon, S., Webster, M. S., DeVoogd, T. J., & Dhondt, A. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230283 · Cited by 9 · see citing works

Influence of tetramethylenedisulfotetramine on synchronous calcium oscillations at distinct developmental stages of hippocampal neuronal cultures

Cao, Z., Xu, J., Hulsizer, S., Cui, Y., Dong, Y., & Pessah, I. N. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.10.015 · Cited by 9 · see citing works

Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95

Frank, D. F., Miller, G. W., Connon, R. E., Geist, J. P., & Lein, P. J. (2017) · PeerJ · doi:10.7717/peerj.4106 · Cited by 9 · see citing works

Isoflurane Alters Presynaptic Endoplasmic Reticulum Calcium Dynamics in Wild-Type and Malignant Hyperthermia-Susceptible Rodent Hippocampal Neurons

Osman, V., Speigel, I. A., Patel, K., & Hemmings, H. C. (2023) · eNeuro · doi:10.1523/eneuro.0114-23.2023 · Cited by 8 · see citing works

Disruption of biomolecule function by nanoparticles: How do gold nanoparticles affect Phase I biotransformation of persistent organic pollutants?

Lu, Z., Ma, G., Veinot, J. G. C., & Wong, C. S. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.05.004 · Cited by 8 · see citing works

Environmental Factors and Autism Spectrum Disorder

Persico, A. M., & Merelli, S. (2015) · Key issues in mental health (Online)/Key issues in mental health (Print) · doi:10.1159/000363611 · Cited by 8 · see citing works

Widespread Emissions of Polychlorinated Biphenyls from Building Materials in Vermont Schools

Hua, J. B. X., Marek, R. F., Jones, M. P., Erb, T. D., Owen, S., & Hornbuckle, K. C. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c10939 · Cited by 7 · see citing works

PCB-95 Modulates the Calcium-Dependent Signaling Pathway Responsible for Activity-Dependent Dendritic Growth

Wayman, G. A., Bose, D. D., Yang, D., Lesiak, A. J., Bruun, D. A., Impey, S., Ledoux, V. A., Pessah, I. N., & Lein, P. J. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104833 · Cited by 136 · see citing works

Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats

Yang, D., Kim, K. H., Phimister, A., Bachstetter, A. D., Ward, T. R., Stackman, R. W., Mervis, R. F., Wisniewski, A. B., Klein, S. L., Kodavanti, P. R. S., et al. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.11771 · Cited by 166 · see citing works

The Environmental Neurotoxicant PCB 95 Promotes Synaptogenesis via Ryanodine Receptor-Dependent miR132 Upregulation

Lesiak, A., Zhu, M., Chen, H., Appleyard, S. M., Impey, S., Lein, P. J., & Wayman, G. A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2884-13.2014 · Cited by 85 · see citing works

3,3′‐Dichlorobiphenyl (PCB 11) Promotes Dendritic Arborization in Primary Neurons via CREB‐Dependent Mechanisms

Sethi, S., Keil, K. P., Wei, F., Dong, Y., He, G., Li, X., Pessah, I. N., Denison, M. S., Lehmler, H., & Lein, P. J. (2018) · The FASEB Journal · doi:10.1096/fasebj.2018.32.1_supplement.691.1

PCB 136 Atropselectively Alters Morphometric and Functional Parameters of Neuronal Connectivity in Cultured Rat Hippocampal Neurons via Ryanodine Receptor-Dependent Mechanisms

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