The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Focal adhesion kinase in integrin-mediated signaling
Open accessAbstract
Integrins serve as adhesion receptors for extracellular matrix proteins and also transduce biochemical signals into the cell. These signaling events regulate such cellular processes as proliferation, apoptosis, migration and spreading. Focal adhesion kinase (FAK) is an important protein tyrosine kinase which mediates several integrin signaling pathways. Putative mechanisms of integrin-mediated FAK activation and localization to focal adhesions are discussed here. FAK interacts with a number of signaling and cytoskeletal proteins, including Src, phosphatidylinositol 3-kinase, Grb2, p130Cas and paxillin. Both the mechanisms and outcomes of these interactions are also presented. Finally, FAK's roles in the regulation of several integrin-mediated cellular events are discussed, including the promotion of cell migration, proliferation and spreading, and the prevention of cell apoptosis.
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Cites
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Li, Y.-S. J., Haga, J. H., & Chien, S. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2004.09.030 · Cited by 904
Dermal Wound Healing Is Subject to Redox Control
Roy, S., Khanna, S., Nallu, K., Hunt, T. K., & Sen, C. K. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2005.07.684 · Cited by 472
Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions
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Nucleus alignment and cell signaling in fibroblasts: response to a micro-grooved topography
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Retracted
Metadata
- Authors
- Cary, L.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 1999
- Volume
- 4
- Issue
- 1-3
- Pages
- d102
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/cary
- OpenAlex
- W2120324368
- Cited by
- 346
- References
- 136
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
