Stem cell theory for the pathogenesis of endometriosis
Open accessAbstract
Proposed hypothetical causes of endometriosis include retrograde menstruation, lymphatic and vascular metastasis, iatrogenic direct implantation, coelomic metaplasia, embryonic rest, and mesenchymal cell differentiation (induction). Each theory, individually, fails to account for all types of endometriotic lesions, thereby implicating combined and/or type-specific mechanisms. Recent evidence supports the presence of endometrial stem/progenitor cells and their possible involvement in eutopic endometrial regeneration and differentiation. Thus an additional novel mechanism for the origin of endometriotic lesions is that they arise from ectopic endometrial stem/progenitor cells.
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Mesenchymal stem cells may travel from other tissues such as bone marrow to repopulate the progenitor population.
“Although progenitor stem cells reside in the uterus, mesenchymal stem cells may also travel from other tissues such as bone marrow to repopulate the progenitor population.105,106”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [106]
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References 80 · Cited by 109
Research works printed but not linked: 2
- Katabuchi, H.: Endometriosis as an enigmatic pelvic disease (Japanese). Journal of Japan Society of Endometriosis, 29, 22-31 (2008)
- Halban, J.: Hysteroadenosis mestica. Wein Kin Wochenschr, 37, 1205 (1924)
- Authors
- Maruyama, T.
- Affiliations
- Keio University (JP)
- Corresponding author
- Maruyama, Tetsuo
- ORCID
- Maruyama, Tetsuo
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2012
- Volume
- E4
- Issue
- 8
- Pages
- 2754-2763
- ISSN
- 1944-7892 (ISSN-L)
- 1945-0494
- 1945-0508
- DOI
- 10.2741/e589
- OpenAlex
- W2316125911
- Cited by
- 109
- References
- 80
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 11 · 2016: 8 · 2015: 8 · 2014: 9 · 2013: 9 · 2012: 3
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in Bioscience-Elite (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Keio University
- Japan Society for the Promotion of Science
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, endometrial stem cells, stem/progenitor cells, endometriosis pathogenesis, endometrial regeneration, mesenchymal differentiation, retrograde menstruation
- MeSH terms
- Endometriosis, Female, Humans, Models, Theoretical, Stem Cells
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