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Genetic relatedness of ceftriaxone-resistant and high-level azithromycin resistant Neisseria gonorrhoeae cases, United Kingdom and Australia, February to April 2018
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Between February and April 2018, three ceftriaxone-resistant and high-level azithromycin-resistant Neisseria gonorrhoeae cases were identified; one in the United Kingdom and two in Australia. Whole genome sequencing was used to show that the isolates from these cases belong to a single gonococcal clone, which we name the A2543 clone.
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“in 2018, the first strain with ceftriaxone resistance plus high-level resistance to azithromycin was isolated in the United Kingdom of Great Britain and Northern Ireland and Australia (11).”
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Metadata
- Authors
- Jennison, A. V., Whiley, D., Lahra, M. M., Graham, R. M., Cole, M. J., Hughes, G., Fifer, H., Andersson, M., Edwards, A., & Eyre, D.
- Affiliations
- Queensland Health (AU)
- The University of Queensland (AU)
- UNSW Sydney (AU)
- Public Health England (GB)
- Universidade de São Paulo (BR)
- Oxford University Hospitals NHS Trust (GB)
- University of Oxford (GB)
- ORCID
- Venue
- Eurosurveillance
- Published
- 2019-02-21
- Volume
- 24
- Issue
- 8
- ISSN
- 1025-496X (ISSN-L)
- 1560-7917
- PMC
- PMC6446956
- OpenAlex
- W2917634477
- Cited by
- 114
- References
- 15
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 17 · 2023: 13 · 2022: 16 · 2021: 23 · 2020: 24 · 2019: 8
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Eurosurveillance (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- Neisseria gonorrhoeae, ceftriaxone resistance, azithromycin resistance, genetic relatedness, whole genome sequencing, gonorrhea, antimicrobial resistance, United Kingdom, Australia
- MeSH terms
- Whole Genome Sequencing, Adult, Anti-Bacterial Agents, Australia, Ceftriaxone, Genotype, Gonorrhea, United Kingdom, Humans, Male, Microbial Sensitivity Tests, Neisseria gonorrhoeae, Phylogeny, Azithromycin, Sentinel Surveillance, Polymorphism, Single Nucleotide, Drug Resistance, Bacterial
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