The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
microPET-Based Biodistribution of Quantum Dots in Living Mice
Open accessAbstract
UNLABELLED: This study evaluates the quantitative biodistribution of commercially available CdSe quantum dots (QD) in mice. METHODS: (64)Cu-Labeled 800- or 525-nm emission wavelength QD (21- or 12-nm diameter), with or without 2,000 MW (molecular weight) polyethylene glycol (PEG), were injected intravenously into mice (5.55 MBq/25 pmol QD) and studied using well counting or by serial microPET and region-of-interest analysis. RESULTS: Both methods show rapid uptake by the liver (27.4-38.9 %ID/g) (%ID/g is percentage injected dose per gram tissue) and spleen (8.0-12.4 %ID/g). Size has no influence on biodistribution within the range tested here. Pegylated QD have slightly slower uptake into liver and spleen (6 vs. 2 min) and show additional low-level bone uptake (6.5-6.9 %ID/g). No evidence of clearance from these organs was observed. CONCLUSION: Rapid reticuloendothelial system clearance of QD will require modification of QD for optimal utility in imaging living subjects. Formal quantitative biodistribution/imaging studies will be helpful in studying many types of nanoparticles, including quantum dots.
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Thorne, R. G., & Nicholson, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509425103 · Cited by 641
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Zhou, M., Zhang, R., Huang, M., Lu, W., Song, S., Melancon, M. P., Tian, M., Liang, D., & Li, C. (2010) · Journal of the American Chemical Society · doi:10.1021/ja106855m · Cited by 718
Metadata
- Authors
- Schipper, M. L., Cheng, Z., Lee, S.-W., Bentolila, L. A., Iyer, G., Rao, J., Chen, X., Wu, A. M., Weiss, S., & Gambhir, S. S.
- Venue
- Journal of Nuclear Medicine
- Publisher
- Society of Nuclear Medicine
- Published
- 2007-08-17
- Volume
- 48
- Issue
- 9
- Pages
- 1511-1518
- ISSN
- 0161-5505 (ISSN-L)
- OpenAlex
- W2165480503
- Cited by
- 203
- References
- 1
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schipper, M. L., Cheng, Z., Lee, S.-W., Bentolila, L. A., Iyer, G., Rao, J., Chen, X., Wu, A. M., Weiss, S., & Gambhir, S. S. (2007). microPET-Based Biodistribution of Quantum Dots in Living Mice. Journal of Nuclear Medicine. https://doi.org/10.2967/jnumed.107.040071
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