Pre-eclampsia: a mitochondrial disease?
Abstract
Mitochondrial dysfunction is a newly found group of inborn errors of metabolism in which there is a failure in the aerobic energy production. Disorders of mitochondrial metabolism exhibit a wide range of clinical symptoms which are related to the nature, severity and tissue distribution of the metabolic defect. Most reported cases are published in the neurological literature. In this report we describe for the first time a family with mitochondrial dysfunction with a high incidence of pre-eclampsia/eclampsia. The diagnosis of a mitochondrial disorder is verified by electronmicroscopic, electromyographic, histochemical and biochemical examinations. During pregnancy, the energy demand is increased due to both fetal and maternal requirements. A mitochondrial dysfunction, clinically symptomless in the non-pregnant state, may therefore become manifest during pregnancy. Characteristic features of pre-eclampsia such as disturbed ion transport, disturbed prostaglandin synthesis, vasoconstriction, platelet aggregation and hyperuricemia may be explained by mitochondrial dysfunction.
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Six of 10 women with a mitochondrial disease had at least one pregnancy complicated by preeclampsia or eclampsia, whereas none had been hypertensive in the non-pregnant state.
“Six of 10 women with a mitochondrial disease had at least one pregnancy complicated by preeclampsia or eclampsia, whereas none had been hypertensive in the non-pregnant state.”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [196]
Torbergsen et al. first suggested that mitochondria might be involved in the pathogenesis of preeclampsia based upon the high frequency of preeclampsia in a family suffering from mitochondrial dysfunction.
“Torbergsen et al.(196) first suggested that mitochondria might be involved in the pathogenesis of preeclampsia based upon the high frequency of preeclampsia in a family suffering from mitochondrial dysfunction.”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [196]
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- Authors
- Torbergsen, T., øian, P., Mathiesen, E., & Borud, O.
- Affiliations
- University Hospital of North Norway (NO)
- Corresponding author
- Torbergsen, Torberg
- ORCID
- Mathiesen, Ellisiv
- Venue
- Acta Obstetricia Et Gynecologica Scandinavica
- Publisher
- Wiley
- Published
- 1989-01
- Volume
- 68
- Issue
- 2
- Pages
- 145-148
- ISSN
- 0001-6349 (ISSN-L)
- 1600-0412
- OpenAlex
- W1972194386
- Cited by
- 83
- References
- 12
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 5 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 5
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Obstetricia Et Gynecologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- preeclampsia, eclampsia, mitochondrial dysfunction, inborn errors of metabolism, pregnancy, energy metabolism, prostaglandin synthesis, vasoconstriction, platelet aggregation, hyperuricemia, ion transport, familial case
- MeSH terms
- Adult, Eclampsia, Female, Humans, Infant, Newborn, Mitochondria, Mitochondria, Muscle, Pre-Eclampsia, Pregnancy, Pregnancy Outcome
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