Decongestion of Nasal Mucous Membranes by Oral Medication in Acute Rhinitis
Abstract
Clinical trials of antihistamines combined with adrenergic substances showed a dccongestive effect on nasal mucosal congestion due to acute rhinitis. Double-blind technique combined with objective rhinomano-meiry over 9 hours in each individual trial showed complete absence of placebo effect; the results were therefore conclusive. Tests on 85 subjects with acute rhinitis as well as tests on 50 normal subjects with histamine-pro-voked nasal blocking support the idea that an antihistamine and an adrenergic substance show synergism with regard to nasal decongestion. Of the drugs tested, clemastine combined with phenylpropanolamine gave the best result.
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In Aschan 1974, positive rhinomanometric changes in nasal patency occurred in 24 of 30 participants after a single dose of active treatment, and no positive changes occurred with placebo (P < 0.001).
“Aschan 1974 recorded positive rhinomanometric changes in nasal patency in 24 of 30 participants after a single dose of the active treatment. There were no positive changes with placebo (P < 0.001).”
From Oral antihistamine-decongestant-analgesic combinations for the common cold (2022) · cites this paper as Aschan 1974
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- Authors
- Aschan, G.
- Affiliations
- Linköping University (SE)
- Corresponding author
- Aschan, G.
- Venue
- Acta Oto-Laryngologica
- Publisher
- Informa UK Limited
- Published
- 1974-01
- Volume
- 77
- Issue
- 1-6
- Pages
- 433-438
- ISSN
- 0001-6489 (ISSN-L)
- 1651-2251
- OpenAlex
- W2036099195
- Cited by
- 33
- References
- 9
- Citations by year
- 2022: 1 · 2018: 1 · 2015: 1 · 2012: 1
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Oto-Laryngologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
- Keywords
- acute rhinitis, nasal congestion, nasal decongestion, antihistamines, adrenergic agents, clemastine, phenylpropanolamine, drug synergy, rhinomanometry, histamine challenge, placebo effect
- MeSH terms
- Acute Disease, Administration, Oral, Aerosols, Airway Obstruction, Clemastine, Clinical Trials as Topic, Drug Synergism, Drug Therapy, Combination, Ephedrine, Histamine, Humans, Nasal Mucosa, Phenylpropanolamine, Placebos, Promethazine, Rhinitis, Vasoconstrictor Agents
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