The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Molecular anatomy of the neuro-immune connection
Abstract
Light microscopic immunohistochemistry was employed to elucidate and compare the presence, distribution, and coexistence of various peptides, neuroendocrine markers and enzymes of the catecholamine pathway in nerves supplying lymphoid tissues in a variety of mammalian species. All lymphoid organs and tissues receive innervation by fibers containing dopamine-beta-hydroxylase and/or tyrosine hydroxylase, neural markers like protein gene product 9.5, synaptophysin and neurofilament and a varied spectrum of peptides. The prominent peptides were tachykinins (substance P, neurokinin A), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), and vasoactive intestinal polypeptide/peptide histidine isoleucine (VIP/PHI). Opioid innervation was variable. Double immunofluorescence revealed coexistence of tachykinins and CGRP and of tyrosine hydroxylase and NPY. A minor proportion of fibers showed coexistence of NPY and tachykinins and of VIP/PHI and tachykinins. The possible importance of the complex peptidergic innervation of lymphoid tissues in inflammation, allergy, inflammatory pain and psycho-neuro-immuno-endocrine network function is discussed. A special immunomodulatory role of the sensory neurons is suggested.
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Citations
Cites
Noradrenergic and peptidergic innervation of lymphoid tissue
Felten, D. L., Felten, S. Y., Carlson, S. L., Olschowka, J. A., & Livnat, S. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.2.755 · Cited by 1,025
Stress and immunity: An integrated view of relationships between the brain and the immune system
Dantzer, R., & Kelley, K. W. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90345-7 · Cited by 534
Neuroendocrine, Sympathetic and Metabolic Responses Induced by Interleukin-1
Berkenbosch, F., de Goeij, D. E. C., del Rey, A., & Besedovsky, H. O. (2008) · Neuroendocrinology · doi:10.1159/000125283 · Cited by 162
Cited by
Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252
Bacteria activate sensory neurons that modulate pain and inflammation
Chiu, I. M., Heesters, B. A., Ghasemlou, N., Von Hehn, C. A., Zhao, F., Tran, J., Wainger, B., Strominger, A., Muralidharan, S., Horswill, A. R., et al. (2013) · Nature · doi:10.1038/nature12479 · Cited by 949
Physiology of psychoneuroimmunology: A personal view
Besedovsky, H. O., & Rey, A. D. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.09.008 · Cited by 202
Metadata
- Authors
- Weihe, E., Nohr, D., Michel, S., Müller, S., Zentel, H. J., Fink, T., & Krekel, J.
- Venue
- International Journal of Neuroscience
- Publisher
- Informa UK Limited
- Published
- 1991-01
- Volume
- 59
- Issue
- 1-3
- Pages
- 1-23
- ISSN
- 0020-7454 (ISSN-L)
- 1543-5245
- OpenAlex
- W2014594657
- Cited by
- 202
- References
- 3
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weihe, E., Nohr, D., Michel, S., Müller, S., Zentel, H. J., Fink, T., & Krekel, J. (1991). Molecular anatomy of the neuro-immune connection. International Journal of Neuroscience. https://doi.org/10.3109/00207459108985446
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