Stress and immunity: An integrated view of relationships between the brain and the immune system

Dantzer, Robert; Kelley, Keith W.

doi:10.1016/0024-3205(89)90345-7

Cited by 534Stress Responses and CortisolCancer, Stress, Anesthesia, and Immune ResponseTryptophan and brain disorders

Stress and immunity: An integrated view of relationships between the brain and the immune system

Dantzer, Robert, Kelley, Keith W.·1989·Life Sciences

DOI 10.1016/0024-3205(89)90345-7

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Abstract

The old notion that stress exacerbates the progression of physical illness via its corticosteroid-mediated immunosuppressive effects must be revised. Experimental and clinical studies demonstrate that both laboratory and natural stressors alter the activities of lymphocytes and macrophages in a complex way that depends on the type of immune response, the physical and psychological characteristics of the stressor and the timing of stress relative to the induction and expression of the immune event. The influences of stress on immunity are mediated not only by glucocorticoids but also by catecholamines, endogenous opioids and pituitary hormones such as growth hormone. Sensitivity of the immune system to stress is not simply fortuitous but is an indirect consequence of the regulatory reciprocal influences that exist between the immune system and the central nervous system. The immune system receives signals from the brain and the neuroendocrine system via the autonomic nervous system and hormones and sends information to the brain via cytokines. These connections appear to be part of a long-loop regulatory feedback system that plays an important role in the coordination of behavioral and physiological responses to infection and inflammation.

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Peripherally produced pro-inflammatory cytokines act on the brain to cause the behavioural symptoms of sickness.
“However, these peripherally produced cytokines also act on the brain to cause the aforementioned behavioural symptoms of sickness.”
From From inflammation to sickness and depression: when the immune system subjugates the brain (2008) · cites this paper as [3]

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From inflammation to sickness and depression: when the immune system subjugates the brain
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“In the late 1980s, scientists articulated that sickness behaviors represent an organized, highly adaptive response to infection (Hart, 1988) and that this response is mediated by cytokines (Dantzer & Kelley, 1989, 2007).”
Background
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Authors: Dantzer, R., & Kelley, K. W.
Affiliations: Inserm (FR)
University of Illinois Urbana-Champaign (US)
ORCID: Dantzer, Robert
Kelley, Keith W.
Venue: Life Sciences
Publisher: Elsevier BV
Published: 1989
Volume: 44
Issue: 26
Pages: 1995-2008
ISSN: 0024-3205 (ISSN-L)
DOI: 10.1016/0024-3205(89)90345-7
OpenAlex: W2012740861
Cited by: 534
References: 97
Citations by year: 2025: 2 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 16 · 2020: 9 · 2019: 11 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 18 · 2014: 9 · 2013: 15 · 2012: 16
FWCI: 6.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Life Sciences (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: National Institutes of Health (AG 06246)
U.S. Department of Agriculture (86-CRCR-I-2003)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: stress, immunity, neuroimmune interactions, glucocorticoids, immunosuppression, catecholamines, endogenous opioids, growth hormone, cytokines, autonomic nervous system, neuroendocrine regulation, lymphocytes, macrophages, infection, inflammation
MeSH terms: Animals, Biological Factors, Brain, Hormones, Humans, Immune Tolerance, Stress, Physiological, Stress, Psychological, Cytokines, Neurotransmitter Agents

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Stress and immunity: An integrated view of relationships between the brain and the immune system

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