Vitamin C in the Treatment of Schizophrenia
Abstract
This report concerns a 37-year-old chronic schizophrenic patient who derived substantial benefit from the addition of ascorbic acid (vitamin C) to his neuroleptic treatment. The case highlights the potential usefulness of vitamin C as an adjunctive agent in the treatment of chronic schizophrenia.
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Chronic psychiatric patients require much higher doses of ascorbic acid to excrete normal content of vitamin C.
“Various studies reported that chronic psychiatric patients, for example with schizophrenia, require much higher doses of ascorbic acid to excrete the normal content of vitamin C (Sandyk and Kanofsky 1993).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Sandyk and Kanofsky 1993
Cites
Detailed mapping of ascorbate distribution in rat brain
Milby, K. H., Oke, A., & Adams, R. N. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90201-4 · Cited by 151 · see citing works
Regional distribution of ascorbate in human brain
Mefford, I. N., Oke, A. F., & Adams, R. N. (1981) · Brain Research · doi:10.1016/0006-8993(81)90056-1 · Cited by 107 · see citing works
Tolbert, L. C., Thomas, T. N., Middaugh, L. D., & Zemp, J. W. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90091-2 · Cited by 96 · see citing works
Schizophrenia and dopamine regulation in the mesolimbic system
Stevens, J. R. (1979) · Trends in Neurosciences · doi:10.1016/0166-2236(79)90041-9 · Cited by 87 · see citing works
The nucleus accumbens–possible site of antipsychotic action of neuroleptic drugs?
Crow, T. J., Deakin, J. F. W., & Longden, A. (1977) · Psychological Medicine · doi:10.1017/s0033291700029287 · Cited by 80 · see citing works
Rebec, G. V., Centore, J. M., White, L. K., & Alloway, K. D. (1985) · Science · doi:10.1126/science.4038426 · Cited by 71 · see citing works
Ascorbic Acid in Chronic Psychiatric Patients —A Controlled Trial
Milner, G. (1963) · The British Journal of Psychiatry · doi:10.1192/bjp.109.459.294 · Cited by 65 · see citing works
Thomas, T. N., & Zemp, J. W. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10440.x · Cited by 53 · see citing works
On the Orthomolecular Environment of the Mind: Orthomolecular Theory
Pauling, L. C. (1974) · American Journal of Psychiatry · doi:10.1176/ajp.131.11.1251 · Cited by 49 · see citing works
Experimental therapeutics of movement disorders.
Fahn, S., Calne, D. B., & Shoulson, I. (1983) · PubMed · Cited by 37 · see citing works
On-off effects in Parkinson's disease: a controlled investigation of ascorbic acid therapy.
Reilly, D. K., Hershey, L. A., Rivera‐Calimlim, L., & Shoulson, I. (1983) · PubMed · Cited by 35 · see citing works
Response to Neuroleptic Drugs as a Device for Classifying Schizophrenia
Brown, W. A., & Herz, L. R. (1989) · Schizophrenia Bulletin · doi:10.1093/schbul/15.1.123 · Cited by 34 · see citing works
Augmentation of haloperidol by ascorbic acid in phencyclidine intoxication
Giannini, A. J., Loiselle, R. H., Dimarzio, L. R., & Giannini, M. C. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.9.1207 · Cited by 34 · see citing works
An Adjunctive Role for Ascorbic Acid in the Treatment of Schizophrenia?
Beauclair, L., Vinogradov, S., Riney, S. J., et al. (1987) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198708000-00037 · Cited by 31 · see citing works
The potential use of vitamin E and selenium in Parkinsonism
Cadet, J. L. (1986) · Medical Hypotheses · doi:10.1016/0306-9877(86)90089-7 · Cited by 30 · see citing works
Ascorbic acid and the binding of DA agonists to neostriatal membrane preparations
Heikkila, R. E., Manzino, L., Cabbat, F. S., & Hanly, J. G. (1983) · Neuropharmacology · doi:10.1016/0028-3908(83)90274-5 · Cited by 22 · see citing works
Plasma levels and urinary vitamin C excretion in schizophrenic patients.
Subotičanec, K., Folnegović-Smalc, V., Turcin, R., et al. (1986) · PubMed · Cited by 16 · see citing works
Dr. Pauling Comments on the Comments
Pauling, L. C. (1974) · American Journal of Psychiatry · doi:10.1176/ajp.1974.131.12.1405 · Cited by 14 · see citing works
Journal of the American college of nutrition
(1994) · Journal of the American Dietetic Association · doi:10.1016/0002-8223(94)91965-8 · Cited by 13 · see citing works
Letter: Dr. Pauling comments on the comments.
Pauling, L. C. (1974) · PubMed · Cited by 12 · see citing works
Phebus, L. A., Roush, M. E., & Clemens, J. A. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90195-w · Cited by 11 · see citing works
A biochemical abnormality in schizophrenia involving ascorbic acid.
VANDERKAMP, H. (1966) · PubMed · Cited by 8 · see citing works
Ascorbate an adjunctive treatment for schizophrenia
Kanofsky, J. D., Kay, S. R., Lindenmayer, J., et al. (1989) · Journal of the American College of Nutrition · Cited by 6 · see citing works
Self-citationAscorbic Acid and Dopamine Activity
Kanofsky, J. D., Kay, S. R., Lindenmayer, J., et al. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.7.904-b · Cited by 4 · see citing works
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
- Authors
- Sandyk, R., & Kanofsky, J. D.
- Affiliations
- Albert Einstein College of Medicine (US)
- ORCID
- Kanofsky, J Daniel
- Venue
- International Journal of Neuroscience
- Publisher
- Informa UK Limited
- Published
- 1993-01
- Volume
- 68
- Issue
- 1-2
- Pages
- 67-71
- ISSN
- 0020-7454 (ISSN-L)
- 1543-5245
- OpenAlex
- W2040891412
- Cited by
- 16
- References
- 24
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 4 · 2020: 1 · 2017: 2 · 2015: 1
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- vitamin C, chronic schizophrenia, adjunctive therapy, antipsychotic drugs, antipsychotic augmentation
- MeSH terms
- Adult, Ascorbic Acid, Chronic Disease, Drug Therapy, Combination, Haloperidol, Humans, Male, Schizophrenia, Treatment Outcome
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