The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance
Abstract
Six patients with a unique form of diabetes associated with extreme insulin resistance have markedly reduced insulin binding to specific receptors on their circulating monocytes. When normal insulin receptors were exposed to serum or immunoglobulin fractions from three of these patients in vitro the specific binding defect was reproduced.
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Cites
The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration
Mogensen, C. E. (1968) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365516809076979 · Cited by 2,654
Autoimmune Response to Acetylcholine Receptor
Patrick, J., & Lindstrom, J. (1973) · Science · doi:10.1126/science.180.4088.871 · Cited by 1,043
Gavin, J. R., Roth, J., Neville, D. M., De Meyts, P., & Buell, D. N. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.1.84 · Cited by 1,040
Self-citationTHYROID-STIMULATING IMMUNOGLOBULINS IN GRAVES' DISEASE
SMITH, B. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91815-7 · Cited by 567
Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse
Kahn, C. R., Neville, D. M., & Roth, J. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44468-2 · Cited by 408
Self-citationQuantitative Aspects of the Insulin-Receptor Interaction in Liver Plasma Membranes
Kahn, C. R., Freychet, P., Roth, J., & Neville, D. M. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42825-1 · Cited by 373
Self-citationExperimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs.
Lennon, V. A., Lindstrom, J. M., & Seybold, M. E. (1975) · The Journal of experimental medicine · doi:10.1084/jem.141.6.1365 · Cited by 335
Characteristics of the Human Lymphocyte Insulin Receptor
Gavin, J. R., Gorden, P., Roth, J., Archer, J. A., & Buell, D. N. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44205-1 · Cited by 318
Self-citationBinding of 125I-Human Growth Hormone to Specific Receptors in Human Cultured Lymphocytes
Lesniak, M. A., Görden, P., Roth, J., & Gavin, J. R. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42840-8 · Cited by 229
Self-citationDefect in insulin binding to receptors in obese man. Amelioration with calorie restriction.
Archer, J. A., Gorden, P., & Roth, J. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107907 · Cited by 225
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Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L.-L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 399
Direct demonstration that receptor crosslinking or aggregation is important in insulin action
Kahn, C. R., Baird, K. L., Jarrett, D. B., & Flier, J. S. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4209 · Cited by 389
Self-citationARIOGLU, E., ANDEWELT, A., DIABO, C., BELL, M., TAYLOR, S. I., & GORDEN, P. (2002) · Medicine · doi:10.1097/00005792-200203000-00001 · Cited by 223
Insulin autoimmune syndrome: from diagnosis to clinical management
Censi, S., Mian, C., & Betterle, C. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.07.32 · Cited by 152
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Metadata
- Authors
- Flier, J. S., Kahn, C. R., Roth, J., & Bar, R. S.
- Venue
- Science
- Published
- 1975-10-03
- Volume
- 190
- Issue
- 4209
- Pages
- 63-65
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2095449282
- Cited by
- 438
- References
- 16
- FWCI
- 18.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance. https://app.cochat.ai/papers/10.1126/science.170678
- The paper
- Flier, J. S., Kahn, C. R., Roth, J., & Bar, R. S. (1975). Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance. Science. https://doi.org/10.1126/science.170678
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
