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Cited by 117Thyroid Disorders and TreatmentsCircadian rhythm and melatoninClinical Laboratory Practices and Quality Control

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Circadian Variation of the Serum Thyrotropin Level in Normal Subjects

Weeke, J.·1973·Scandinavian Journal of Clinical and Laboratory Investigation
DOI 10.3109/00365517309082440
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Abstract

A circadian rhythm of serum thyrotropin (TSH) has been demonstrated by measurements performed on half-hourly blood samples collected over a 24-hour period from 8 healthy young men and 5 healthy young women. The serum TSH level decreased from 8 a.m. to 11 a.m. There was a low level during the day-time with a mean serum TSH value of 0.85 μU/ml. The level increased in the evening between 8 p.m. and 11 p.m., and a higher TSH level was maintained during the night, with a mean value of 1.34 Ü/ml. The difference between day and night level was highly significant. There was no relation between the meals and the variation of the TSH level. The rise of serum TSH preceded the onset of sleep. The circadian rhythm of serum TSH is not only of physiological interest but has also the practical consequence that blood sample collection for TSH determinations is best performed at 11 a.m., when the TSH level has fallen to the day-time level.

Overview

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Crossref · 10.3109/00365517309082440

Cites

22 of 22 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 7

  1. Adlkofer F., 1972, Acta endocr. (Kbh.), 159
  2. Nicoloff J. T, 1912, J. clin. Invest., 49
  3. Nicoloff J. T., 1922, J. clin. Invest., 49
  4. Oerskov H, 1960, Scand. J. clin. Lab. Invest., 19, 1157
  5. Singh D. V., 1967, P.S.E.B.M., 126, 553
  6. Sollberger A. Biological Rhythm Research. Elsevier, Amsterdam 1965; 228–230
  7. Weeke J., J. Lab. clin. Med

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Metadata

Authors
Weeke, J.
Affiliations
Aarhus Municipality (DK)
Corresponding author
Weeke, J.
Venue
Scandinavian Journal of Clinical and Laboratory Investigation
Publisher
Informa UK Limited
Published
1973-01
Volume
31
Issue
3
Pages
337-342
ISSN
  • 0036-5513 (ISSN-L)
  • 1502-7686
DOI
10.3109/00365517309082440
OpenAlex
W2028796360
Cited by
117
References
22
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2016: 1 · 2015: 2 · 2013: 2 · 2012: 1
FWCI
6.65
Type
journal article
Language
en
Open access
closed
Locations
  • Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Keywords
thyroid-stimulating hormone, circadian rhythm, serum TSH, diurnal variation, sleep onset, blood sampling timing, healthy volunteers
MeSH terms
Adult, Animals, Buffers, Cattle, Chloramines, Chromatography, Gel, Chromatography, Paper, Circadian Rhythm, Female, Humans, Immune Sera, Iodine Radioisotopes, Isotope Labeling, Male, Mercury, Methods, Organometallic Compounds, Rabbits, Radioimmunoassay, Serum Albumin, Bovine, Sulfites, Thyrotropin, Time Factors

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