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Diurnal pattern of insulin requirements in insulin-dependent diabetics
Abstract
A total of 35 experiments in which insulin-dependent diabetics were connected to an artificial beta cell (Biostator) for feedback control of blood glucose during at least 24 h, were evaluated. Only 14 experiments, however, were available for analysis, since interruptions of more than 45 min/24 h in feedback control due to clots in analyser tubing occurred in those remaining. In these 14 experiments the 24-h insulin-infusion pattern was analysed. Basal insulin requirements (BIR), (between 01.00 and 04.00 hours) was found to be 0.178 +/- 0.044 (SD) mU/kg X min. Insulin requirements increased in the early morning (04.00-07.00 hours) to 0.231 +/- 0.084 mU/kg X min (P less than 0.01). A significant correlation between BIR and 24-h insulin requirement was found (r = 0.53, P less than 0.05). Insulin requirements per kJ following breakfast were higher than after lunch, 0.57 +/- 0.20 muU/kg X min X kJ versus 0.41 +/- 0.29 muU/kg X min X kJ (P less than 0.05).
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In the citing paper
“Although some (20,24,27) but not all (21–23,26) studies that used the Biostator controlled for physical activity levels, meal sizes, composition, and calorie content varied from meal to meal in all but one (27).”
From Diurnal Pattern of Insulin Action in Type 1 Diabetes (2013) · cites this paper as [20]
In the citing paper
“With use of the Biostator, Mathiesen et al. (20) demonstrated that insulin requirements per kilojoule consumed was higher at breakfast than at lunch, thereby implying a lower insulin action at breakfast than at lunch”
From Diurnal Pattern of Insulin Action in Type 1 Diabetes (2013) · cites this paper as [20]
In the citing paper
“Although the diurnal pattern of SI in type 1 diabetic subjects in the present study concords to the albeit indirect observations of Mathiesen et al. (20), important differences in study designs must be noted”
From Diurnal Pattern of Insulin Action in Type 1 Diabetes (2013) · cites this paper as [20]
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Cited by
Diurnal Pattern of Insulin Action in Type 1 Diabetes
Hinshaw, L., Dalla Man, C., Nandy, D. K., Saad, A., Bharucha, A. E., Levine, J. A., Rizza, R. A., Basu, R., Carter, R. E., Cobelli, C., et al. (2013) · Diabetes · doi:10.2337/db12-1759 · Cited by 125
Metadata
- Authors
- Mathiesen, E. R., Rubin, P., Christiansen, J. S., Svendsen, P. A., Lauritzen, T., & Deckert, T.
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 1982
- Volume
- 42
- Issue
- 1
- Pages
- 63-68
- ISSN
- 0036-5513 (ISSN-L)
- OpenAlex
- W4252041577
- Cited by
- 10
- References
- 0
- Citations by year
- 2018: 1 · 2016: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- insulin requirement, diurnal variation, type 1 diabetes, insulin dose
- MeSH terms
- Adult, Blood Glucose, Circadian Rhythm, Diabetes Mellitus, Type 1, Equipment Design, Feedback, Female, Humans, Insulin, Insulin Infusion Systems, Male, Middle Aged
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Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Diurnal pattern of insulin requirements in insulin-dependent diabetics. https://app.cochat.ai/papers/10.3109/00365518209168051
- The paper
- Mathiesen, E. R., Rubin, P., Christiansen, J. S., Svendsen, P. A., Lauritzen, T., & Deckert, T. (1982). Diurnal pattern of insulin requirements in insulin-dependent diabetics. Scandinavian Journal of Clinical and Laboratory Investigation. https://doi.org/10.3109/00365518209168051
