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Heartburn without Oesophagitis: Efficacy of Omeprazole Therapy and Features Determining Therapeutic Response
Abstract
BACKGROUND: Data are limited on the value of effective antisecretory therapy in the relief of heartburn in patients without oesophagitis. METHODS: Patients with heartburn, without endoscopic signs of oesophagitis, were randomized to double-blind treatment with omeprazole, 20 or 10 mg once daily, or placebo, for 4 weeks (n = 509). Pre-treatment oesophageal acid exposure was assessed using 24-h intra-oesophageal pH monitoring. Heartburn was assessed at 2 and 4 weeks. RESULTS: At 4 weeks the proportion of patients with complete absence of heartburn was 46% (95% confidence interval, 39-53%) with 20 mg omeprazole, 31% (25-38%) with 10 mg omeprazole, and 13% (7-20%) with placebo. Satisfaction with therapy was reported by 66%, 57%, and 31% of the patients, respectively. CONCLUSION: Omeprazole, 20 and 10 mg once daily, provides rapid relief of heartburn in patients without endoscopic oesophagitis.
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Cited by
NOJKOV, B., RUBENSTEIN, J. H., ADLIS, S. A., SHAW, M. J., SAAD, R., RAI, J., WEINMAN, B., & CHEY, W. D. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03596.x · Cited by 101
Food and Gastroesophageal Reflux Disease
Surdea-Blaga, T., Negrutiu, D. E., Palage, M., & Dumitrascu, D. L. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867324666170515123807 · Cited by 101
Metadata
- Authors
- Lind, T., Havelund, T., Carlsson, R., Anker-Hansen, O., Glise, H., Hernqvist, H., Junghard, O., Lauritsen, K., Lundell, L., Pedersen, S. A., & Stubberöd, A.
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 1997-01
- Volume
- 32
- Issue
- 10
- Pages
- 974-979
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W2060152915
- Cited by
- 413
- References
- 0
- FWCI
- 11.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lind, T., Havelund, T., Carlsson, R., Anker-Hansen, O., Glise, H., Hernqvist, H., Junghard, O., Lauritsen, K., Lundell, L., Pedersen, S. A., & Stubberöd, A. (1997). Heartburn without Oesophagitis: Efficacy of Omeprazole Therapy and Features Determining Therapeutic Response. Scandinavian Journal of Gastroenterology. https://doi.org/10.3109/00365529709011212
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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