The influence of co‐morbid IBS and psychological distress on outcomes and quality of life following PPI therapy in patients with gastro‐oesophageal reflux disease
Open accessAbstract
Summary: Background A subset of patients with gastro‐oesophageal reflux disease (GERD) does not achieve complete symptom resolution with proton pump inhibitor (PPI) therapy. The factors which affect response to PPI therapy in GERD patients remain unclear. Aims To determine the prevalence and impact of irritable bowel syndrome (IBS) and psychological distress (PD) on GERD symptoms and disease‐specific quality of life (QoL) before and after PPI therapy and to assess the same outcomes before and after PPI therapy in non‐erosive reflux disease (NERD) and erosive oesophagitis (EO) GERD patients. Methods Patients undergoing oesophago‐gastroduodenoscopy (OGD) for heartburn were recruited. Participants completed validated surveys: Digestive Health Symptom Index, Reflux Disease Questionnaire, Quality of Life in Reflux and Dyspepsia and Brief Symptom Inventory (BSI). IBS was defined as >3 Manning criteria and PD as BSI score >63. At OGD, patients were classified as NERD or EO. Patients were treated with rabeprazole 20 mg/day for 8 weeks before completing follow‐up surveys. Results Of 132 GERD patients enrolled, 101 completed the study. The prevalence rates of IBS and PD were 36% and 41%, respectively. IBS independently predicted worse QoL before and after PPI therapy. PD independently predicted worse GERD symptoms and QoL before and after PPI therapy. There were no differences in symptoms or QoL between NERD and EO patients before or after PPI therapy. Conclusions IBS and PD impacted GERD symptoms and QoL before and after PPI therapy. Symptoms and QoL before and after PPI therapy were similar in NERD and EO patients.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The concomitant presence of IBS or psychological distress in GERD patients predicted higher symptom ratings and lower quality of life before and after PPI treatment.
“In addition, the concomitant presence of IBS or psychological distress in GERD patients predicted higher symptom ratings and lower quality of life before and after PPI treatment, making this subset of patients a therapeutic challenge.20”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [20]
The ‘Impact of co-morbid PD on GERD symptoms and QoL’ section supports higher symptom burden and worse disease-specific quality of life before and after PPI therapy among patients with psychological distress. The ‘Impact of co-morbid IBS’ section supports higher symptoms and worse quality of life before treatment, but IBS was not associated with post-treatment symptom scores, and its lower post-treatment quality-of-life scores were not statistically significant. The claim overstates the post-treatment findings for IBS. (LLM, conf=0.90)
Experimental — accuracy not yet measuredAnother study found 36 percent prevalence of IBS in GERD patients.
“Another study found 36 percent prevalence of IBS in GERD patients.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Spitzer, R. L. (1999) · JAMA · doi:10.1001/jama.282.18.1737 · Cited by 9,802 · see citing works
The brief symptom inventory: an introductory report.
Derogatis, L. R., & Melisaratos, N. (1983) · Psychological Medicine · doi:10.1017/s0033291700048017 · Cited by 6,650 · see citing works
Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Grant Thompson, W., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E., et al. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303162 · Cited by 2,198 · see citing works
Locke, G. R., Talley, N. J., Fett, S. L., ZINSMEISTER, A. R., & Melton, L. J. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70025-8 · Cited by 2,090 · see citing works
Towards positive diagnosis of the irritable bowel.
Manning, A. P., Thompson, W., Heaton, K. W., & Morris, A. F. (1978) · BMJ · doi:10.1136/bmj.2.6138.653 · Cited by 1,404 · see citing works
Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease
DeVault, K. R., & Castell, D. O. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41217.x · Cited by 1,130 · see citing works
Altered rectal perception is a biological marker of patients with irritable bowel syndrome
Mertz, H., Naliboff, B. D., Munakata, J., Niazi, N., & Mayer, E. A. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90267-8 · Cited by 976 · see citing works
An evidence-based appraisal of reflux disease management — the Genval Workshop Report
Dent, J., Brun, J., Fendrick, A. M., Fennerty, M. B., Janssens, J., Kahrilas, P. J., Lauritsen, K., Reynolds, J. C., Shaw, M., & Talley, N. J. (1998) · Gut · doi:10.1136/gut.44.2008.s1 · Cited by 891 · see citing works
Self-citationChiba, N., Gara, C. D., Wilkinson, J., & Hunt, R. H. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9178669 · Cited by 854 · see citing works
Obesity Is an Independent Risk Factor for GERD Symptoms and Erosive Esophagitis
El‐Serag, H. B., Graham, D. Y., Satia, J. A., & Rabeneck, L. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41703.x · Cited by 570 · see citing works
Effectiveness of proton pump inhibitors in nonerosive reflux disease
Dean, B. B., Gano, A. D., Knight, K., Ofman, J. J., & Fass, R. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00288-5 · Cited by 461 · see citing works
Gastro-oesophageal reflux disease in primary care
Carlsson, R., Dent, J., Watts, R., Riley, S. A., Sheikh, R., Hatlebakk, J. G., Haug, K., de Groot, G. H., van Oudvorst, A., Dalväg, A., et al. (1998) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199802000-00004 · Cited by 436 · see citing works
Gastro-oesophageal reflux disease
Moayyedi, P., & Talley, N. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68932-0 · Cited by 433 · see citing works
Lind, T., Havelund, T., Carlsson, R., Anker-Hansen, O., Glise, H., Hernqvist, H., Junghard, O., Lauritsen, K., Lundell, L. R., Pedersen, S. A., et al. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709011212 · Cited by 412 · see citing works
Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease
Shaw, M. J., Talley, N. J., Beebe, T. J., Rockwood, T. H., Carlsson, R., Adlis, S. A., Fendrick, A. M., Jones, R. H., Dent, J., & Bytzer, P. M. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03451.x · Cited by 403 · see citing works
Self-citationNon‐erosive reflux disease (NERD) — acid reflux and symptom patterns
Martinez, S. D., Malagon, I. B., Garewal, H. S., Cui, H., & Fass, R. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01423.x · Cited by 396 · see citing works
Systematic review: proton‐pump inhibitor failure in gastro‐oesophageal reflux disease – where next?
Fass, R., Shapiro, M. J., Dekel, R., & Sewell, J. L. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02531.x · Cited by 394 · see citing works
ACG Practice Guidelines: Esophageal Reflux Testing
Hirano, I., & Richter, J. E. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00936.x · Cited by 352 · see citing works
Qadeer, M. A., Phillips, C. O., López, R., Steward, D. L., Noordzij, J. P., Wo, J. M., Suurna, M. V., Havas, T. E., Howden, C. W., & Vaezi, M. F. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00844.x · Cited by 288 · see citing works
Wiklund, I. (1998) · The European Journal of Surgery · doi:10.1080/11024159850191238 · Cited by 275 · see citing works
Wong, W. M., Lai, K. C., Lam, K., Hui, W. M., Hu, W. H. C., Lam, C. L. K., Xia, H. H., Huang, J., Chan, C. K., Lam, S. K., et al. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01737.x · Cited by 273 · see citing works
Overlap of gastrointestional symptom complexes in a US community
Locke, G., Zinsmeister, A., Fett, S., Melton, L., & Talley, N. (2005) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2004.00581.x · Cited by 254 · see citing works
Agréus, L., Svärdsudd, K., Talley, N. J., Jones, M. P., & Tibblin, G. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.04680.x · Cited by 244 · see citing works
Heightened visceral sensation in functional gastrointestinal disease is not site-specific
Trimble, K. C., Farouk, R., Pryde, A., Douglas, S., & Heading, R. C. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02212678 · Cited by 243 · see citing works
Corsetti, M., Caenepeel, P., Fischler, B., Janssens, J., & Tack, J. F. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.30040.x · Cited by 167 · see citing works
The Effect of Life Stress on Symptoms of Heartburn
Naliboff, B. D., Mayer, M., Fass, R., FitzGerald, L., Chang, L., Bolus, R. R., & Mayer, E. A. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000124756.37520.84 · Cited by 146 · see citing works
Studying the Overlap Between IBS and GERD: A Systematic Review of the Literature
Nastaskin, I., Mehdikhani, E., Conklin, J., Park, S., & Pimentel, M. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9306-y · Cited by 98 · see citing works
Psychological distress in patients with gastroesophageal reflux disease.
Baker, L. H., Lieberman, D. A., & Oehlke, M. A. (1995) · PubMed · Cited by 87 · see citing works
Shaw, Talley, Adlis, Beebe, Tomshine, & Healey (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00399.x · Cited by 86 · see citing works
Lee, Y., Wang, H., Chiu, H., Liao, S., Huang, S., Lai, Y., Wu, M., CHEN, M., & Lin, J. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.04034.x · Cited by 83 · see citing works
Reflux symptoms are associated with psychiatric disease
Avidan, B., Sonnenberg, A., Giblovich, H., & Sontag, S. J. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.01131.x · Cited by 80 · see citing works
Chey, W. D., Inadomi, J. M., Booher, A. M., Sharma, V. K., Fendrick, A. M., & Howden, C. W. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41364.x · Cited by 68 · see citing works
Self-citationSymptom-relieving Effect of Esomeprazole 40 mg Daily in Patients with Heartburn
Johnsson, F., Hatlebakk, J. G., Klintenberg, A.-C., & Román, J. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310002157 · Cited by 44 · see citing works
Gastroesophageal Reflux Disease
(2006) · Springer eBooks · doi:10.1007/3-540-29719-0_658 · Cited by 34 · see citing works
Gastroesophageal reflux disease and irritable bowel syndrome: A common overlap syndrome
Dickman, R., Feroze, H., & Fass, R. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0045-1 · Cited by 26 · see citing works
Shaw, M. J., Beebe, T. J., Adlis, S. A., & Talley, N. J. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.01026.x · Cited by 23 · see citing works
Self-citationGalmiche, J. P. (2006) · Drugs · doi:10.2165/00003495-200666001-00003 · Cited by 18 · see citing works
Erosive esophagitis and NERD: Can we really classify patients with heartburn by endoscopic findings?
Chey, W. D. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00287-3 · Cited by 15 · see citing works
Self-citationPogromov, A. P., Diukova, G. M., Sm, R., & Am, B. (2005) · PubMed · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 42 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Baker LH, Lieberman D, Oehlke M. Psy- chological distress in patients with gas- troesophageal reflux disease. Am J Gastroenterol 1995; 90: 1797-803.
- Carlsson R, Dent J, Watts R, et al. Gas- tro-esophageal reflux disease in primary care: an international study of different treatment strategies with omeprazole. Eur J Gastroentrol Hepatol 1998; 10: 119-24.
- Moayyedi P, Talley NJ. Gastroesopha- geal reflux disease. Lancet 2006; 367: 2086-100.
Cited by
Sorted by citations
Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors
Sifrim, D. A., & Zerbib, F. (2012) · Gut · doi:10.1136/gutjnl-2011-301897 · Cited by 340 · see citing works
Management of heartburn not responding to proton pump inhibitors
Fass, R., & Sifrim, D. A. (2009) · Gut · doi:10.1136/gut.2007.145581 · Cited by 320 · see citing works
Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015
Iwakiri, K., Kinoshita, Y., Habu, Y., Oshima, T., Manabe, N., Fujiwara, Y., Nagahara, A., Kawamura, O., Iwakiri, R., Ozawa, S., et al. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1227-8 · Cited by 284 · see citing works
Wu, Y., Murray, G. K., Byrne, E. M., Sidorenko, J., Visscher, P. M., & Wray, N. R. (2021) · Nature Communications · doi:10.1038/s41467-021-21280-7 · Cited by 212 · see citing works
ESNM/ANMS consensus paper: Diagnosis and management of refractory gastro‐esophageal reflux disease
Zerbib, F., Bredenoord, A. J., Fass, R., Kahrilas, P. J., Roman, S., Savarino, E. V., Sifrim, D. A., Vaezi, M. F., Yadlapati, R. H., & Gyawali, C. P. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.14075 · Cited by 163 · see citing works
Diagnosis and management of non-erosive reflux disease–the Vevey NERD Consensus Group
Modlin, I. M., Hunt, R. H., Malfertheiner, P., Moayyedi, P., Quigley, E. M., Tytgat, G. N. J., Tack, J., Heading, R. C., Holtman, G., & Moss, S. F. (2009) · Digestion · doi:10.1159/000219365 · Cited by 154 · see citing works
Zerbib, F., BELHOCINE, K., Simon, M., Capdepont, M., Mion, F., Varannes, S. B. D., & Galmiche, J. (2011) · Gut · doi:10.1136/gutjnl-2011-300798 · Cited by 129 · see citing works
Sharma, P., Shaheen, N. J., Pérez, M. C., Pilmer, B. L., LEE, M., Atkinson, S. N., & Peura, D. A. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.03933.x · Cited by 118 · see citing works
Management of the patient with incomplete response to PPI therapy
Kahrilas, P. J., Boeckxstaens, G. E., & Smout, A. J. P. M. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.06.005 · Cited by 117 · see citing works
Spiegel, B. M. R., Chey, W. D., & Chang, L. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01992.x · Cited by 95 · see citing works
Self-citationFass, R., Chey, W. D., Zakko, S. F., Andhivarothai, N., Palmer, R. N., Pérez, M. C., & Atkinson, S. N. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04013.x · Cited by 93 · see citing works
Self-citationProton Pump Inhibitor Failure—What Are the Therapeutic Options?
Fass, R. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.50 · Cited by 90 · see citing works
Pharmacologic and Complementary and Alternative Medicine Therapies for Irritable Bowel Syndrome
Chey, W. D., Maneerattaporn, M., & Saad, R. (2011) · Gut and Liver · doi:10.5009/gnl.2011.5.3.253 · Cited by 89 · see citing works
Self-citationSperber, A. D., & Dekel, R. (2010) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2010.16.2.113 · Cited by 85 · see citing works
Ostovaneh, M., Saeidi, B., Hajifathalian, K., Farrokhi‐Khajeh‐Pasha, Y., Fotouhi, A., Mirbagheri, S., Emami, H., Barzin, G., & Mirbagheri, S. A. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12313 · Cited by 83 · see citing works
Proton pump inhibitor-refractory gastroesophageal reflux disease: challenges and solutions
Mermelstein, J., Mermelstein, A. C., & Chait, M. M. (2018) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s121056 · Cited by 79 · see citing works
He, M., Wang, Q., Yao, D., Li, J., & Bai, G. (2022) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm21044 · Cited by 76 · see citing works
Management of gastroesophageal reflux disease that does not respond well to proton pump inhibitors
Hershcovici, T., & Fass, R. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32833ae2be · Cited by 75 · see citing works
AGA Clinical Practice Update on Functional Heartburn: Expert Review
Fass, R., Zerbib, F., & Gyawali, C. P. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.034 · Cited by 74 · see citing works
Treatment patterns and symptom control in patients with GERD: US community-based survey
Chey, W. D., Mody, R., Wu, E. Q., Chen, L., Kothari, S., Persson, B., Beaulieu, N., & Lü, M. (2009) · Current Medical Research and Opinion · doi:10.1185/03007990903035745 · Cited by 70 · see citing works
Self-citationChey, W. D., Mody, R., & Izat, E. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1209-2 · Cited by 64 · see citing works
Self-citationLifestyle factors associated with gastroesophageal reflux disease in the Japanese population
Matsuki, N., Fujita, T., Watanabe, N., Sugahara, A., Watanabe, A., Ishida, T., Morita, Y., Yoshida, M., Kutsumi, H., Hayakumo, T., et al. (2012) · Journal of Gastroenterology · doi:10.1007/s00535-012-0649-1 · Cited by 63 · see citing works
An algorithm for diagnosis and treatment of refractory GERD
Hershcovici, T., & Fass, R. (2010) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2010.10.004 · Cited by 60 · see citing works
Review article: gastro‐oesophageal reflux disease and psychological comorbidity
Mizyed, I., Fass, S. S., & Fass, R. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03883.x · Cited by 59 · see citing works
Overlap of functional heartburn and gastroesophageal reflux disease with irritable bowel syndrome
de Bortoli, N. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i35.5787 · Cited by 55 · see citing works
Heading, R. C., Mönnikes, H., Tholen, A., & Schmitt, H. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-52 · Cited by 55 · see citing works
Analysis of the Gastrointestinal Symptoms of Uninvestigated Dyspepsia and Irritable Bowel Syndrome
Hori, K., Matsumoto, T., & Miwa, H. (2009) · Gut and Liver · doi:10.5009/gnl.2009.3.3.192 · Cited by 53 · see citing works
Therapeutic options for refractory gastroesophageal reflux disease
Fass, R. (2012) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2012.07064.x · Cited by 53 · see citing works
Updated Guidelines 2012 for Gastroesophageal Reflux Disease
Jung, H., Hong, S. J., Jo, Y., Jeon, S. W., Cho, Y. K., Lee, K. J., Lee, J. S., Park, H., Shin, E. S., Lee, S. H., et al. (2012) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2012.60.4.195 · Cited by 53 · see citing works
Step-by-step management of refractory gastresophageal reflux disease
Hershcovici, T., & Fass, R. (2012) · Diseases of the Esophagus · doi:10.1111/j.1442-2050.2011.01322.x · Cited by 52 · see citing works
Current Pharmacological Management of Gastroesophageal Reflux Disease
Wang, Y., Hsu, W., Wang, S. S. W., Lu, C., Kuo, F., Su, Y.-C., Yang, S., Chen, C., Wu, D., & Kuo, C. (2013) · Gastroenterology Research and Practice · doi:10.1155/2013/983653 · Cited by 52 · see citing works
Gąsiorowska, A., Poh, C. H., & Fass, R. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0594-2 · Cited by 49 · see citing works
Gastro-Oesophageal Reflux Disease
Hershcovici, T., & Fass, R. (2011) · Drugs · doi:10.2165/11597300-000000000-00000 · Cited by 44 · see citing works
Лазебник, Л. Б., Голованова, Е. В., Volel, B. A., Korochanskaya, N. V., Lyalyukova, E. A., Мокшина, М. В., Насрединович, М. С., Мехтиева, О. А., Metsaeva, Z. V., Petelin, D. S., et al. (2021) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-192-8-5-117 · Cited by 43 · see citing works
Risk factors and populations at risk: Selection of patients for screening for Barrett's oesophagus
Rubenstein, J. H., & Thrift, A. P. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.11.009 · Cited by 40 · see citing works
Self-citationKim, S. E., Kim, N., Oh, S., Kim, H. M., Park, M. I., Lee, D. H., & Jung, H. C. (2014) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14078 · Cited by 40 · see citing works
Mönnikes, H., Schwan, T., van Rensburg, C., Straszak, A., Theek, C., Sander, P., & Lühmann, R. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05085.x · Cited by 36 · see citing works
Functional Heartburn: Definition and Management Strategies
Zerbib, F., Varannes, S. B. D., Simon, M., & Galmiche, J. P. (2012) · Current Gastroenterology Reports · doi:10.1007/s11894-012-0255-7 · Cited by 29 · see citing works
Wu, J. C. Y., Lai, L., Chow, D. K., Wong, G. L., Sung, J. J. �., & Chan, F. K. L. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01627.x · Cited by 27 · see citing works
Impact of gastroesophageal reflux disease on the quality of life of Polish patients
Gorczyca, R., Pardak, P., Pękala, A., & Filip, R. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i12.1421 · Cited by 24 · see citing works
Nonmedical Therapeutic Strategies for Nonerosive Reflux Disease
Maradey–Romero, C., Kale, H. P., & Fass, R. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000125 · Cited by 24 · see citing works
Wang, A. J., Wang, H., Xu, L., Lv, N. H., He, X., Hong, J. B., You, Y., & Zhu, X. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.11.017 · Cited by 23 · see citing works
Mearin, F., Ponce, J., Ponce, M., Balboa, A., González, M. A., & Zapardiel, J. (2012) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3283512139 · Cited by 23 · see citing works
Rome Foundation Working Team Report on overlap in disorders of gut–brain interaction
Barbara, G., Aziz, I., Ballou, S., Chang, L., Ford, A. C., Fukudo, S., Nurko, S., Olano, C., Saps, M., Sayuk, G. S., et al. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-01033-9 · Cited by 30 · see citing works
Zhong, C., Liu, K., Wang, K., Liu, H., Su, H., Wu, J., & Duan, L. (2018) · Diseases of the Esophagus · doi:10.1093/dote/doy039 · Cited by 22 · see citing works
Lang, F., Huber, A., Kowalewski, K., Kenngott, H. G., Billmann, F. G., Billeter, A. T., Fischer, L., Bintintan, V. V., Gutt, C. N., Müller-Stich, B. P., et al. (2022) · Surgical Endoscopy · doi:10.1007/s00464-021-08969-y · Cited by 22 · see citing works
Distinction between patients with non-erosive reflux disease and functional heartburn.
Giacchino, M., Savarino, V., & Savarino, E. V. (2013) · Europe PMC (PubMed Central) · Cited by 22 · see citing works
Garros, A., Mion, F., Marjoux, S., Damon, H., & Roman, S. (2015) · Diseases of the Esophagus · doi:10.1111/dote.12374 · Cited by 20 · see citing works
Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease.
Mönnikes, H., Heading, R. C., Schmitt, H., & Doerfler, H. (2011) · Europe PMC (PubMed Central) · doi:10.3748/wjg.v17.i27.3235 · Cited by 19 · see citing works
New Approaches to Management of PPI-Refractory Gastroesophageal Reflux Disease
Ateşž, F., & Vaezi, M. F. (2014) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-013-0002-7 · Cited by 19 · see citing works
Yin, X., Wu, H., Zhang, B., Zhu, N., Chen, T., Ma, X., Zhang, L., Lv, L. L., Zhang, M., Wang, F., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14631 · Cited by 18 · see citing works
Boltin, D., Boaz, M., Aizic, S., Sperber, A. D., Fass, R., Niv, Y., & Dickman, R. M. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.08.008 · Cited by 17 · see citing works
GERD: An Alternative Perspective
Ho, C. E., Goh, Y. L., Zhao, X. X., Yu, C. Y., & Zhang, C. (2015) · Psychosomatics · doi:10.1016/j.psym.2015.10.007 · Cited by 16 · see citing works
Refractory gastroesophageal reflux disease: advances and treatment
Ateşž, F., Francis, D. O., & Vaezi, M. F. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.910454 · Cited by 15 · see citing works
Díaz, M. A. V., Amieva‐Balmori, M., Carmona-Sánchez, R., Coss‐Adame, E., Gomez-Escudero, O., González-Martínez, M. A., Huerta-Iga, F. M., Morel-Cerda, E. C., Remes-Troche, J. M., la Cuesta, J. L. T.-D., et al. (2024) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2023.12.002 · Cited by 13 · see citing works
Current and emerging therapies for the management of functional gastrointestinal disorders
Craig, O. F., & Quigley, E. M. M. (2010) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622310389507 · Cited by 13 · see citing works
Treatment of GORD: Three decades of progress and disappointments
Galmiche, J. P., Zerbib, F., & Varannes, S. B. D. (2013) · United European Gastroenterology Journal · doi:10.1177/2050640613484021 · Cited by 13 · see citing works
Richter, J. E. (2014) · Europe PMC (PubMed Central) · Cited by 11 · see citing works
Rubenstein, J. H., Li, J., Kurlander, J. E., Chen, J. W., Metko, V., Khodadost, M., Nofz, K., & Raghunathan, T. E. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.08.044 · Cited by 11 · see citing works
Self-citationCai, S. T., Wang, L. Y., Sun, G., Peng, L. H., Guo, X., Wang, W. F., & Yang, Y. S. (2015) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12262 · Cited by 10 · see citing works
Vakil, N. B., Niklasson, A., Denison, H., & Rydén, A. (2014) · United European Gastroenterology Journal · doi:10.1177/2050640614558343 · Cited by 10 · see citing works
Kinoshita, Y., & Ishihara, S. (2008) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x08098181 · Cited by 10 · see citing works
Endotherapy for and tailored approaches to treating GERD, and refractory GERD
Locke, G. R., Horwhat, J. D., Mashimo, H. L., Savarino, E. V., Zentilin, P., Savarino, V., Zerbib, F., Armbruster, S. P., Wong, R. K. H., & Moawad, F. J. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12240 · Cited by 9 · see citing works
Goh, K., Choi, K. D., Choi, M., Hsieh, T., Jung, H., Lien, H., Menon, J., Mesenas, S. J., Park, H., Sheu, B., et al. (2014) · BMC Gastroenterology · doi:10.1186/1471-230x-14-156 · Cited by 9 · see citing works
Valdovinos-Díaz, M. A., Amieva‐Balmori, M., Carmona-Sánchez, R., Coss‐Adame, E., Gomez-Escudero, O., González-Martínez, M. A., Huerta-Iga, F. M., Morel-Cerda, E. C., Remes-Troche, J. M., la Cuesta, J. L. T.-D., et al. (2024) · Revista de Gastroenterología de México · doi:10.1016/j.rgmx.2023.12.002 · Cited by 8 · see citing works
Neumann, H., Neurath, M. F., Vieth, M. W., Lever, F. M., Meijer, G. J., Lips, I. M., McMahon, B. P., Ruurda, J. P. H., van Hillegersberg, R., Siersema, P. D., et al. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12233 · Cited by 8 · see citing works
Psychological modulation in patients surgically intervened for gastroesophageal reflux disease
Lara, F. J. P., Carranque, G. A., Reyes, H. O. D. L., Hernández‐Rivas, J. M., & Oliva, H. G. (2012) · Diseases of the Esophagus · doi:10.1111/j.1442-2050.2012.01443.x · Cited by 8 · see citing works
Gastroesophageal Reflux Disease
Richter, J. E., & Friedenberg, F. K. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6189-2.00043-3 · Cited by 8 · see citing works
Caldart, F., Gabriel, C., Vauquelin, B., Rivière, P., Berger, A., & Zerbib, F. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003542 · Cited by 9 · see citing works
Mönnikes, H., Schwan, T., Rensburg, C. V., Straszak, A., Theek, C., Lühmann, R., Sander, P., & Tholen, A. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-145 · Cited by 7 · see citing works
Psychological Comorbidity and Chronic Heartburn: Which Is the Chicken and Which Is the Egg?
Fass, R., & Fass, S. S. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4475-4 · Cited by 7 · see citing works
Odaka, T., Yamato, S., & Yokosuka, O. (2017) · Current Therapeutic Research · doi:10.1016/j.curtheres.2017.03.007 · Cited by 6 · see citing works
The Overlap Between GERD and Functional Bowel Disorders - When East Meets Rome
Hershcovici, T., & Fass, R. (2010) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2010.16.2.105 · Cited by 5 · see citing works
Therapieresistente Refluxkrankheit
Labenz, J., & Feußner, H. (2009) · Die Gastroenterologie · doi:10.1007/s11377-009-0290-6 · Cited by 5 · see citing works
Gastroesophageal Reflux Disease
Roman, S., Pandolfino, J. E., & Kahrilas, P. J. (2015) · Yamada's Textbook of Gastroenterology · doi:10.1002/9781118512074.ch49 · Cited by 5 · see citing works
Funaki, Y., Kaneko, H., Kawamura, Y., Yoshimine, T., Tamura, Y., Izawa, S., Ebi, M., Ogasawara, N., Sasaki, M., & Kasugai, K. (2017) · Digestion · doi:10.1159/000477801 · Cited by 4 · see citing works
Na, B.-J., & Choi, S.-H. (2012) · Cited by 4 · see citing works
Nonerosive Reflux Disease (NERD)
Abdallah, J., & Fass, R. (2017) · Springer eBooks · doi:10.1007/978-3-319-59352-4_10 · Cited by 4 · see citing works
Valdovinos-Díaz, M. A., Hani, A. C., Defilippi-Guerra, C., Fernando-Pineda, L., Remes-Troche, J. M., Riquelme, A. J., Abrahão-Junior, L. J., Aguilar-Paiz, L., Almonte-Nuñez, C., Burgos, H., et al. (2025) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2025.02.001 · Cited by 3 · see citing works
Novel therapeutics for gastro–esophageal reflux symptoms
Zerbib, F., & Simon, M. (2012) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.12.38 · Cited by 3 · see citing works
Overview of Gastroesophageal Reflux Disease Treatments
Roman, S., & Kahrilas, P. J. (2013) · doi:10.1002/9781118444788.ch4 · Cited by 3 · see citing works
Valdovinos, M. A., Hani, A. C., Defilippi-Guerra, C., Fernando-Pineda, L., Remes-Troche, J. M., Riquelme, A. J., Abrahão-Junior, L. J., Aguilar-Paiz, L., Almonte-Nuñez, C., Burgos, H., et al. (2025) · Revista de Gastroenterología de México · doi:10.1016/j.rgmx.2025.02.001 · Cited by 2 · see citing works
Challenges to Unravel Mechanisms of GERD
Shimoyama, S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80793 · Cited by 1 · see citing works
The Future Therapeutic Landscape of Gastroesophageal Reflux Disease
Kurin, M., & Fass, R. (2025) · Journal of Digestive Diseases · doi:10.1111/1751-2980.13345 · Cited by 1 · see citing works
Medical treatment versus surgery for treatment of gastroesophageal reflux disease
Parekh, P. J., & Johnson, D. A. (2015) · Techniques in Gastrointestinal Endoscopy · doi:10.1016/j.tgie.2015.02.003 · Cited by 1 · see citing works
Zimmerman, J., & Hershcovici, T. (2011) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2011.579997 · Cited by 1 · see citing works
Management of gastroesophageal reflux disease in adults
Niknam, R., Manafi, A., Khazforoosh, S., & Mahmoudi, L. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works
Liao, M., Lin, T., Lee, H., Lin, C., Chen, K., & Wu, D. (2024) · Advances in digestive medicine · doi:10.1002/aid2.13394 · Cited by 1 · see citing works
Психологічна дезадаптація пацієнтів з ГЕРХ: огляд та власні дослідження
Мосійчук, Л. М., Demeshkіna, L. V., Kushnіrenko, І. V., & Зав’Ялова, І. Ю. (2014) · GASTROENTEROLOGY · doi:10.22141/2308-2097.4.54.2014.82000 · Cited by 1 · see citing works
Rahman, M. M., Ghoshal, U. C., Kibria, M. G., Sultana, N., Ahmed, F., Rowshon, A., & Hasan, M. (2020) · JGH Open · doi:10.1002/jgh3.12417 · Cited by 1 · see citing works
Halliez, M. C. M. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/27133 · Cited by 1 · see citing works
Evaluation and Management of Refractory Gastroesophageal Reflux Disease
Pandolfino, J. E., & Roman, S. (2013) · doi:10.1002/9781118444788.ch7
The Problem of Heartburn, and Atypical Chest Pain
Fass, R., & Hershcovici, T. (2011) · doi:10.1002/9781444346381.ch2
Troubles fonctionnels digestifs et reflux gastro-œsophagien
Zerbib, F., & Simon, M. (2012) · HEGEL - HEpato-GastroEntérologie Libérale · doi:10.3917/heg.024.0030
Patient or Physician - Who Is Able to Evaluate Gastroesophageal Reflux Disease Symptoms Better?
Gąsiorowska, A. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.4.335
Treatment of Nonerosive Reflux Disease (Beyond Proton Pump Inhibitors)
Fass, R. (2010) · Revista Portuguesa de Pneumologia
Demeshkіna, L. V., Mosiychuk, L. М., Петішко, О. П., Zygalo, E. V., & Зав’Ялова, І. Ю. (2016) · GASTROENTEROLOGY · doi:10.22141/2308-2097.3.61.2016.79152
ОСОБЛИВОСТІ ПСИХОЛОГІЧНОЇ ДЕЗАДАПТАЦІЇ ПАЦІЄНТІВ ІЗ ГАСТРОЕЗОФАГЕАЛЬНОЮ РЕФЛЮКСНОЮ ХВОРОБОЮ
Martynova, Y. Y., & Kharchuk, Y. V. (2019) · Вісник наукових досліджень · doi:10.11603/2415-8798.2019.2.10019
- Authors
- NOJKOV, B., RUBENSTEIN, J. H., ADLIS, S. A., SHAW, M. J., SAAD, R., RAI, J., WEINMAN, B., & CHEY, W. D.
- Affiliations
- University of Michigan (US)
- Park Nicollet Health Services (US)
- Corresponding author
- CHEY, W. D.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2008-01-10
- Volume
- 27
- Issue
- 6
- Pages
- 473-482
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2136938649
- Cited by
- 101
- References
- 42
- Citations by year
- 2025: 5 · 2024: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 11 · 2013: 12 · 2012: 12
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- Janssen Scientific Affairs
- Eisai
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- gastroesophageal reflux disease, irritable bowel syndrome, psychological distress, proton pump inhibitors, rabeprazole, non-erosive reflux disease, erosive esophagitis, quality of life, heartburn, treatment response, comorbidities
- MeSH terms
- Adolescent, Adult, Aged, Female, Gastroesophageal Reflux, Heartburn, Humans, Male, Middle Aged, Quality of Life, Stress, Physiological, Proton Pumps, Irritable Bowel Syndrome, 2-Pyridinylmethylsulfinylbenzimidazoles, Proton Pump Inhibitors, Rabeprazole
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
