Association of Helicobacter pylori infection with chronic obstructive pulmonary disease and chronic bronchitis: a meta-analysis of 16 studies
Abstract
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and chronic bronchitis (CB) are common respiratory diseases globally. The aim of this meta-analysis was to quantify the risk of these two diseases being associated with Helicobacter pylori infection. METHODS: A literature search was performed to identify studies published before 5 June 2014 for relevant risk estimates. Fixed and random effect meta-analytical techniques were conducted for COPD and CB. RESULTS: Sixteen observational studies involving 1390 patients with COPD, 734 with CB and more than 13 000 controls were included. Helicobacter pylori infection was associated with an increased risk of COPD and CB [odds ratio (OR) 2.07, 95% confidence interval (CI) 1.81-2.36, p for heterogeneity = 0.05; and OR 1.57, 95% CI 1.33-1.86, p for heterogeneity = 0.08]. We discovered a significant association between CagA-positive strains and risk for COPD (OR 3.46, 95% CI 2.29-5.25, p for heterogeneity = 0.20). CONCLUSIONS: Our meta-analysis suggested a potential relationship between H. pylori infection and the development of COPD and CB.
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Helicobacter pylori is linked to peptic ulcer disease, gastric cancer, as well as diabetes, autoimmune disease, chronic inflammation, CVD and endothelial dysfunction.
“Epidemiologically, H. pylori is linked to peptic ulcer disease, gastric cancer, as well as diabetes, autoimmune disease, chronic inflammation, CVD and endothelial dysfunction[240–245].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [240]
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- Authors
- Wang, F., Liu, J., Zhang, Y., & Lei, P.
- Affiliations
- Tianjin Medical University General Hospital (CN)
- Tianjin People's Hospital (CN)
- Corresponding author
- Lei, Ping
- Venue
- Infectious Diseases
- Publisher
- Informa UK Limited
- Published
- 2015-03-21
- Volume
- 47
- Issue
- 9
- Pages
- 597-603
- ISSN
- 0036-5548 (ISSN-L)
- 2374-4235
- 2374-4243
- OpenAlex
- W2086043166
- Cited by
- 33
- References
- 47
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 3 · 2018: 2 · 2017: 2 · 2016: 6
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- Helicobacter pylori infection, chronic obstructive pulmonary disease, chronic bronchitis, CagA-positive strains, disease risk association, respiratory diseases
- MeSH terms
- Humans, Helicobacter Infections, Pulmonary Disease, Chronic Obstructive, Bronchitis, Chronic
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