The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid
Abstract
1. Carnosol and carnosic acid have been suggested to account for over 90% of the antioxidant properties of rosemary extract. 2. Purified carnosol and carnosic acid are powerful inhibitors of lipid peroxidation in microsomal and liposomal systems, more effective than propyl gallate. 3. Carnosol and carnosic acid are good scavengers of peroxyl radicals (CCl3O2.) generated by pulse radiolysis, with calculated rate constants of 1-3 x 10(6) M-1 s-1 and 2.7 x 10(7) M-1 s-1 respectively. 4. Carnosic acid reacted with HOCl in such a way as to protect the protein alpha 1-antiproteinase against inactivation. 5. Both carnosol and carnosic acid stimulated DNA damage in the bleomycin assay but they scavenged hydroxyl radicals in the deoxyribose assay. The calculated rate constants for reaction with .OH in the deoxyribose system for carnosol and carnosic acid were 8.7 x 10(10) M-1 s-1 and 5.9 x 10(10) M-1 s-1 respectively. 6. Carnosic acid appears to scavenge H2O2, but it could also act as a substrate for the peroxidase system. 7. Carnosic acid and carnosol reduce cytochrome c but with a rate constant significantly lower than that of O2(-.).
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Citations
Cites
Tissue Destruction by Neutrophils
Epstein, F. H., & Weiss, S. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902093200606 · Cited by 3,950
Cited by
Free radicals, oxidative stress, and antioxidants in human health and disease
Aruoma, O. I. (1998) · Journal of the American Oil Chemists' Society · doi:10.1007/s11746-998-0032-9 · Cited by 1,682
Self-citationErkan, N., Ayranci, G., & Ayranci, E. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.01.058 · Cited by 734
Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus officinalis, L.): A Review
Nieto, G., Ros, G., & Castillo, J. (2018) · Medicines · doi:10.3390/medicines5030098 · Cited by 574
Vaya, J., Belinky, P. A., & Aviram, M. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00089-0 · Cited by 549
High content of dopamine, a strong antioxidant, in cavendish banana
Kanazawa, K., & Sakakibara, H. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9909860 · Cited by 406
Metadata
- Authors
- Aruoma, O. I., Halliwell, B., Aeschbach, R., & Löligers, J.
- Venue
- Xenobiotica
- Publisher
- Informa UK Limited
- Published
- 1992-01
- Volume
- 22
- Issue
- 2
- Pages
- 257-268
- ISSN
- 0049-8254 (ISSN-L)
- 1366-5928
- OpenAlex
- W2067185653
- Cited by
- 514
- References
- 1
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Aruoma, O. I., Halliwell, B., Aeschbach, R., & Löligers, J. (1992). Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid. Xenobiotica. https://doi.org/10.3109/00498259209046624
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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