Cited by 418Pharmacogenetics and Drug MetabolismDiabetes Treatment and ManagementMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Accumulation of metformin by tissues of the normal and diabetic mouse

Wilcock, C., Bailey, C. J.·1994·Xenobiotica

Open this paper in CoChat — free account

Abstract

1. Tissue accumulation of the antihyperglycaemic agent metformin (dimethylbiguanide) was examined after oral administration to the normal and streptozotocin (STZ) diabetic mouse. 2. Metformin (50 mg/kg body weight containing 14C-metformin 25 microCi/kg body weight), which is stable and not metabolized, resulted in maximum plasma concentrations at 0.5 h which declined to < 5% of maximum by 24 h. Maximum plasma concentrations (mumol/l, mean +/- SE) in the hepatic portal vein (normal 51.7 +/- 5.4, STZ 61.5 +/- 8.0) were higher than in the inferior vena cava (normal 29.0 +/- 2.8, STZ 35.4 +/- 5.9). 3. The greatest accumulation of metformin occurred in tissues of the small intestine, where maximum concentrations were > 1000 mumol/kg wet weight at 0.5-2 h, but declined to < 2% of maximum by 24 h. 4. Stomach, colon, salivary gland, kidney and liver accumulated metformin more than two-fold, and concentrations of the drug in heart and skeletal (gastrocnemius) muscle were greater than plasma concentrations on some occasions up to 8 h. 5. In a separate study, i.v.-administered metformin was selectively accumulated by tissues of the small intestine. Thus, retention of metformin by tissues of the small intestine may represent a deep compartment for the drug.

Integrity signals

Registry

Crossref · 10.3109/00498259409043220

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Verapamil
Singh, B. N., Ellrodt, G. A., & Peter, C. T. (1978) · Drugs · doi:10.2165/00003495-197815030-00001 · Cited by 835
Biguanides and NIDDM
Bailey, C. J. (1992) · Diabetes Care · doi:10.2337/diacare.15.6.755 · Cited by 593
Self-citation
Metformin kinetics in healthy subjects and in patients with diabetes mellitus.
Tucker, G., Casey, C., Phillips, P., Connor, H., Ward, J. D., & Woods, H. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb01206.x · Cited by 503
Pharmacokinetics of Metformin After Intravenous and Oral Administration to Man
Pentik�inen, P. J., Neuvonen, P. J., & Penttil�, A. (1979) · European Journal of Clinical Pharmacology · doi:10.1007/bf00562061 · Cited by 348
Disposition of metformin (N,N‐dimethylbiguanide) in man
Sirtori, C. R., Franceschini, G., Galli-Kienle, M., Cighetti, G., Galli, G., Bondioli, A., & Conti, F. (1978) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1978246683 · Cited by 222
Metformin: a review of its pharmacological properties and therapeutic use.
Ls, H. (1979) · PubMed · Cited by 175
Determination of glucose by an automatic analyser
Stevens, J. F. (1971) · Clinica Chimica Acta · doi:10.1016/0009-8981(71)90332-9 · Cited by 166
Gastrointestinal Motility.
Konturek, S. J. (1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-5-789_4 · Cited by 158
Effect of metformin on glucose metabolism in the splanchnic bed
Bailey, C. J., Wilcock, C., & Day, C. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09093.x · Cited by 131
Self-citation
Metformin in the digestive tract
Vidon, N., Chaussade, S., Noël, M., Franchisseur, C., Huchet, B., & Bernier, J. J. (1988) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(88)80022-6 · Cited by 117

Show all 23 references

Research works printed but not linked: 7

Bailey C. J., 1988, Balliere's Clinical Endocrinology and Metabolism, 2, 455
Bailey C. J., 1986, Diabete et Metabolisme, 12, 212
Cigolini M., 1984, Diabete et Metabolisme, 10, 311
Cohen P. Y., 1961, Therapie, 16, 109
Hermann L. S, 1979, Diabete et Metabolisme, 5, 233
Mordes J. P., 1985, Joslin's Diabetes Mellitus12th edn, 110
Noel M, 1979, Research and Clinical Forums, 1, 35

Sorted by citations

Items 301–400 of 414

Repurposing Metformin for the Treatment of Atrial Fibrillation: Current Insights
Sarkar, A., Fanous, K., Marei, I., Ding, H., Ladjimi, M. M., MacDonald, R. S., Hollenberg, M. D., Anderson, T. J., Hill, M. A., & Triggle, C. R. (2024) · Vascular Health and Risk Management · doi:10.2147/vhrm.s391808 · Cited by 11
Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits
Díez, R., Garcia, J. J., Diez, M. J., Sierra, M., Sahagún, A. M., & Fernández, N. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1809-x · Cited by 11
Metformin prevents the impairment of endothelium-dependent vascular relaxation induced by high glucose challenge in rabbit isolated perfused kidneys
Gomes, M. B., Cailleaux, S., & Tibiriçá, E. V. (2005) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-005-1083-1 · Cited by 11
Anti-obesity and metabolic benefits of metformin: Comparison of different delivery routes
Abbasi, M., Fan, Z., Dawson, J., & Wang, S. F. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105110 · Cited by 10
Metformin: Antidiabetic actions from cells to tissues
Bailey, C. J., Gwilt, M., & Brand, K. M. G. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156589 · Cited by 10
Self-citation
Metformin Transport Rates Between Plasma and Red Blood Cells in Humans
Kurlovičs, J., Zake, D. M., Zaharenko, L., Berzins, K., Kloviņš, J., & Stalidzāns, E. (2021) · Clinical Pharmacokinetics · doi:10.1007/s40262-021-01058-2 · Cited by 11
Metformin Treatment Leads to Increased HIV Transcription and Gene Expression through Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter
Rezaei, S., Timani, K. A., & He, J. J. (2023) · Aging and Disease · doi:10.14336/ad.2023.0705 · Cited by 10
Metformin's Impact on the Microvascular Response to Insulin
Love, K. M., Barrett, E. J., & Horton, W. B. (2022) · Endocrinology · doi:10.1210/endocr/bqac162 · Cited by 10
Metformin Accelerates Glycolytic Lactate Production in Cultured Primary Cerebellar Granule Neurons
Blumrich, E., & Dringen, R. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2346-1 · Cited by 10
Metformin Exerts Beneficial Effects in Hemorrhagic Shock in An AMPKα1-Independent Manner
Kim, P., Piraino, G., O’Connor, M. P., Hake, P. W., Wolfe, V., Lahni, P. M., & Zingarelli, B. (2017) · Shock · doi:10.1097/shk.0000000000000984 · Cited by 10
4-Aminopyridine antagonizes the acute relaxant action of metformin on adrenergic contraction in the ventral tail artery of the rat
Peuler, J. D., Lee, J. M., & Smith, J. M. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00522-6 · Cited by 10
Metformin: A possible drug for treatment of endometrial cancer
Tsuji, K., Kisu, I., Banno, K., Yanokura, M., Ueki, A., Masuda, K., Kobayashi, Y., Yamagami, W., Nomura, H., Susumu, N., et al. (2012) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2012.21001 · Cited by 9
Metformin retention independent of renal failure in intestinal occlusion.
Lalau, J., Race, J., Andréelli, F., Lacroix, C., & Canarelli, J. P. (2001) · PubMed · Cited by 9
Antidiabetes drug metformin is a donor of nitric oxide: EPR measurement of efficiency
Сереженков, В. А., Кузнецов, И. С., Romantsova, T. I., Кузнецова, М., & Vanin, A. F. (2011) · BIOPHYSICS · doi:10.1134/s0006350911060169 · Cited by 9
Impact of currently used anti-diabetic drugs on myoendothelial communication
Ding, H., Ye, K., & Triggle, C. R. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.11.002 · Cited by 9
Exploring the impact of metformin on the central nervous system and neurotransmission: A systematic review
Maciejczyk, A., & Blecharz‐Klin, K. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118743 · Cited by 8
Prescription drugs and mitochondrial metabolism
Schmidt, C. A. (2022) · Bioscience Reports · doi:10.1042/bsr20211813 · Cited by 8
Energy Metabolism and Metformin: Effects on Ischemia-Reperfusion Injury in Kidney Transplantation
Nemeth, D. V., Iannelli, L., Gangitano, E., D’Andrea, V., & Bellini, M. I. (2024) · Biomedicines · doi:10.3390/biomedicines12071534 · Cited by 8
Effect of Metformin on Meibomian Gland Epithelial Cells: Implications in Aging and Diabetic Dry Eye Disease
Rescher, L., Singh, S., Zahn, I., Paulsen, F. P., & Schicht, M. (2024) · Life · doi:10.3390/life14121682 · Cited by 8
Deciphering metformin action in obese mice: A critical re-evaluation of established protocols
Kaplanian, M., Philippe, C., Eid, S. A., Hackl, M. T., Metz, M., Beghini, M., Luca, A. C., Kautzky‐Willer, A., Scherer, T., & Fürnsinn, C. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154956 · Cited by 8
Metoprolol decreases the plasma exposure of metformin via the induction of liver, kidney and muscle uptake in rats
Ma, Y., Shi, A., Qin, H., Zhang, T., Wu, Y., Zhang, G., & Wu, X. (2016) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2041 · Cited by 8
Mécanisme d’action hépatique de la metformine dans le diabète de type 2
Foretz, M., & Viollet, B. (2009) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(09)70104-x · Cited by 12
A review of recent developments in the pharmacological prevention and treatment of endocrinopathic laminitis
de Laat, M. A., & Sillence, M. N. (2020) · Animal Production Science · doi:10.1071/an19491 · Cited by 7
Genetic Polymorphism in the Organic Cation Transporters 1 (OCT1) Gene and its Effect on Therapeutic Efficacy and Gastrointestinal Side Effects of Metformin in Patients with Type 2 Diabetes Mellitus in Basrah/ Southern Iraq.
Aladhab, R. A., Abd, A. H., Alidrisi, H. A., & Alabbood, M. (2023) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2699 · Cited by 7
Quality and Characteristics of 4241 Case Reports of Lactic Acidosis in Metformin Users Reported to a Large Pharmacovigilance Database
Brand, K. M. G., Schlachter, J., Foch, C., & Boutmy, E. (2022) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s372430 · Cited by 7
A purinergic mechanism underlying metformin regulation of hyperglycemia
Senfeld, J. I., Peng, Q., Shi, Y. P., Qian, S., & Shen, J. (2023) · iScience · doi:10.1016/j.isci.2023.106898 · Cited by 7
Time course and dose effect of metformin on weight in patients with different disease states
Chen, X., Wang, D., & Li, Z. (2020) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2020.1822164 · Cited by 7
A Novel Mechanism for Intestinal Absorption of the Type II Diabetes Drug Metformin: Role of Cation-selective Apical Transporters in Paracellular Absorption
Proctor, W. R. (2010) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/a54k-5s46 · Cited by 7
In vitro anti-echinococcal activity of octreotide: Additive effect of metformin linked to autophagy
Loos, J. A., Negro, P., & Cumino, A. C. (2019) · Acta Tropica · doi:10.1016/j.actatropica.2019.105312 · Cited by 7
Inverse relationship between peripheral insulin removal and action: studies with metformin
Zhang, Z., & Radziuk, J. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1240 · Cited by 7
Metformin induces a Lac-Phe gut–brain signalling axis
TeSlaa, T. A. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01014-x · Cited by 7
Association of metformin treatment with changes in metal dynamics in individuals with type 2 diabetes
Otowa‐Suematsu, N., Sakaguchi, K., Yamada, T., Nishisaka, M., Morita, Y., Fukumitsu, H., Katsura, Y., Okada, Y., Hirota, Y., Sugawara, K., et al. (2025) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2025-005255 · Cited by 6
Mitochondrial Ca 2+ in Cancer Growth and Metabolism
Weissenrieder, J., & Foskett, J. K. (2025) · Journal of Cellular Physiology · doi:10.1002/jcp.70093 · Cited by 6
GC–MS analysis of 4-hydroxyproline: elevated proline hydroxylation in metformin-associated lactic acidosis and metformin-treated Becker muscular dystrophy patients
Baskal, S., Posma, R. A., Bollenbach, A., Dieperink, W., Bakker, S. J. L., Nijsten, M. W., Touw, D. J., & Tsikas, D. (2024) · Amino Acids · doi:10.1007/s00726-024-03383-9 · Cited by 6
Analyses of Biguanides and Related Compounds in Biological and Environmental Samples by HPLC
Ali, I., Hussain, I., Sanagi, M. M., Ibrahim, W. A. W., & Aboul-Enein, H. Y. (2014) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2014.940803 · Cited by 6
Metformin alters therapeutic effects in the BALB/c tumor therapy model
Meyer, F., Goebel, S., Spangel, S. B., Leovsky, C., Hoelzer, D., & Thierbach, R. (2021) · BMC Cancer · doi:10.1186/s12885-021-08354-x · Cited by 6
Metabolic effects of pharmaceuticals in fish
Yeh, A., Meador, J. P., Lunsman, T. D., Mayfield, D. B., & Verslycke, T. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-08-102971-8.00013-5 · Cited by 6
Glucose metabolism in mouse embryos exposed to metformin in vitro
Smoak, I. W. (1999) · Toxicology in Vitro · doi:10.1016/s0887-2333(98)00061-7 · Cited by 6
Metformin Boosts Intestinal Lipid Sensing via GIP to Suppress Feeding
Kuah, R., Wang, M. T., Yang, Z., Back, G., Li, R., Bruce, K., LoChoy, J. N., Beaudry, J. L., Barros, D. R., Zhang, S., et al. (2025) · Diabetes · doi:10.2337/db25-0100 · Cited by 5
Glucose Supply and Insulin Demand Dynamics of Antidiabetic Agents
Monte, S. V., Schentag, J. J., Adelman, M. H., & Paladino, J. A. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400219 · Cited by 5
Renal Trapping in Accidental Metformin Intoxication
Posma, R. A., Wessels, A. M. A., Dieperink, W., Roggeveld, J., Leuvenink, H. G. D., van der Horst, I. C. C., den Dunnen, W. F. A., Nijsten, M. W., & Touw, D. J. (2020) · Kidney International Reports · doi:10.1016/j.ekir.2020.06.009 · Cited by 5
The Toxicity Effects of Metformin and the Bioremediation of Metformin in Aquatic Plant Duckweed
Han, B., Jiang, Y., Wang, W., Guo, Y., Yang, Y., He, Y., Di, Q., Qu, Z., Xing, Y., & Yang, L. (2025) · Plants · doi:10.3390/plants14121761 · Cited by 4
Entering the Sugar Rush Era: Revisiting the Antihyperglycemic Activities of Biguanides after a Century of Metformin Discovery
Neto, X. A. D. O., Barssotti, L., Fiori-Duarte, A. T., Barbosa, H. C. L., & Kawano, D. F. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220820151959 · Cited by 4
Anti-echinococcal effect of metformin in advanced experimental cystic echinococcosis: reprogrammed intermediary carbon metabolism in the parasite
Loos, J. A., Negro, P., Ortega, H. H., Salinas, F. J., Arán, M., Pellizza, L., Salerno, G. L., & Cumino, A. C. (2024) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00941-24 · Cited by 5
The Antimalarial Drug Proguanil Is an Antagonist at 5-HT3 Receptors
Lochner, M., & Thompson, A. J. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.218461 · Cited by 4
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength
Imran, M., Sachdeva, G., Menon, S. R., Das, D. K., Davuluri, S., Acharya, K. K., & Chaudhari, U. K. (2022) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2022-0307 · Cited by 4
Antitumoral Effects of Metformin in Ovarian Cancer
Garrido, M. P., Vega, M., & Romero, C. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88911 · Cited by 4
Treatment with Metformin
Bailey, C. J. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1331-8_8 · Cited by 4
Self-citation
Effect of metformin on liver insulin metabolism and regional blood flow
Signore, A., Fiore, V., Chianelli, M., Ronga, G., & Pozzilli, P. (1995) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610110504 · Cited by 4
Equine Metabolic Syndrome
Durham, A. E. (2016) · Wiley eBooks · doi:10.1002/9781119169239.ch36 · Cited by 4
Neuroprotective Roles of Metformin in a Streptozotocin-Induced Dementia Model in Rats
Vizuete, A. F. K., Moreira, A. P., Zin, L. E. F., Marques, C. D. O., Pacheco, R. F., Leal, M. B., Menezes, L., & Gonçalves, C. (2025) · Neurotoxicity Research · doi:10.1007/s12640-025-00771-1 · Cited by 3
Metformin in advanced chronic kidney disease: are current guidelines overly restrictive?
Cole, N. I., Swift, P. A., Suckling, R., & Andrews, P. (2016) · British Journal of Diabetes · doi:10.15277/bjd.2016.106 · Cited by 3
Review on spectroscopic analytical methods for determination of metformin hydrochloride
Abood, N. K., Jamil, D. M., & Abass, A. M. (2020) · International Journal of Research in Engineering and Innovation · doi:10.36037/ijrei.2020.4203 · Cited by 3
Reduced Cytokine Tumour Necrosis Factor by Pharmacological Intervention in a Preclinical Study
Mooranian, A., Chester, J., Johnston, E., Ionescu, C. M., Walker, D. P., Jones, M., Wagle, S. R., Kovačević, B., Foster, T., Mikov, M., et al. (2022) · Biomolecules · doi:10.3390/biom12070877 · Cited by 3
Metformin regulation of progesterone receptor isoform‑B expression in human endometrial cancer cells is glucose‑dependent
Saguyod, S. J. U., Alhallak, I., Simmen, R. C. M., & Velarde, M. C. (2020) · Oncology Letters · doi:10.3892/ol.2020.12112 · Cited by 3
A Rapid and Convenient Method for in Vivo Fluorescent Imaging of Protoscolices of Echinococcus multilocularis
Yang, T., Wang, S., Zhang, X., Xia, J. L., Guo, J., Hou, J., Zhang, H., Chen, X., & Wu, X. (2016) · Korean Journal of Parasitology · doi:10.3347/kjp.2016.54.2.225 · Cited by 3
Metformin: od mehanizmov delovanja do napredne klinične uporabe
Janić, M., Volčanšek, Š., Lunder, M., & Janež, A. (2017) · Slovenian Medical Journal · doi:10.6016/zdravvestn.1503 · Cited by 4
Metformin: Historical Origins, Mechanisms of Action, and Emerging Clinical Applications
Hu, Y., Zhang, X., Yang, C., Wu, X., Ye, X., Yu, J. K., & Yang, Y. (2026) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.70171 · Cited by 3
Metformin
Stümvoll, M., Häring, H., & Matthaei, S. (2007) · CRC Press eBooks · doi:10.3109/9780849379581-10 · Cited by 2
Breast Cancer Models
Üstün, F. (2019) · Nuclear Medicine Seminars · doi:10.4274/nts.galenos.2019.0005 · Cited by 3
Anticonvulsant Profile of Selected Medium-Chain Fatty Acids (MCFAs) Co-Administered with Metformin in Mice in Acute and Chronic Treatment
Pieróg, M., Socała, K., Nieoczym, D., Wyska, E., Samorek-Pieróg, M., & Właź, P. (2023) · Molecules · doi:10.3390/molecules28093810 · Cited by 2
Ianus Bifrons: The Two Faces of Metformin
Goglia, U., Hasballa, I., Teti, C., Boschetti, M., Ferone, D., & Albertelli, M. (2024) · Cancers · doi:10.3390/cancers16071287 · Cited by 2
Combined Administration of Metformin and Propionate Reduces the Degree of Oxidative/Nitrosative Damage of Hypothalamic Neurons in Rat Model of Type 2 Diabetes Mellitus
Натрус, Л. В., Klys, Y., Osadchuk, Y., Anft, M., Westhoff, T. H., & Babel, N. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04529-2 · Cited by 2
Crosstalk of 5′-Monophosphate-Activated Protein Kinase (AMPK) with Extracellular and Intracellular Signaling Pathways in the Regulation of Nutrient Metabolism and Cell Survival in the Liver
Lü, H. (2017) · Current Pharmacology Reports · doi:10.1007/s40495-017-0091-4 · Cited by 2
Metformin İntoksikasyonuna Bağlı Akut Böbrek Yetmezliği: Olgu Sunumu
Kocaoğlu, Ç., & Özel, A. (2018) · Türk yoğun bakım derneği dergisi/Türk yoğun bakım dergisi · doi:10.4274/tybd.26818 · Cited by 2
Should Pharmacokinetic Safety Challenges Prevent Metformin Use in Patients With Cancer?
Wintrob, Z. A. P. (2015) · Journal of Pharmacy Practice · doi:10.1177/0897190014559392 · Cited by 2
Metformin: Pharmacological Action and Nutritional Metabolism
Tanabe, K. (2024) · Nippon Eiyo Shokuryo Gakkaishi · doi:10.4327/jsnfs.77.327 · Cited by 1
Metformin Mitigates Radiation-Induced Endothelial Cell Damage by Attenuating Oxidative Stress, DNA Damage, and Apoptosis
Seo, E., Seo, H., & Lee, K. C. (2025) · CardioMetabolic Syndrome Journal · doi:10.51789/cmsj.2026.6.e6 · Cited by 1
Acidosis láctica y metformina. Tratamiento combinado con hemodiálisis y hemofiltración
López, J. C., Esteve, F., Jubert, E., Villanueva, H., & Pérez, X. L. (2007) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(07)71493-6 · Cited by 1
Metformin in patients with ischemic heart disease and type 2 diabetes mellitus: mechanism of action and clinical efficiency
Кравчук, Е. Н., & Galagudza, M. M. (2013) · Diabetes Mellitus · doi:10.14341/2072-0351-3590 · Cited by 1
High dose targeted delivery on cancer sites and the importance of short-chain fatty acids for metformin's action: Two crucial aspects of the wonder drug
Maniar, K., Singh, V., Chakrabarti, A., Bhattacharyya, R., & Banerjee, D. (2018) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2018.05.013 · Cited by 1
Cation-selective Apical Transporters Mediate an Intestinal Cycling Mechanism of Metformin that Enhances its Paracellular Oral Absorption in Mice
Costales, C. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/v7v6-s548 · Cited by 1
Metformin, Diyabet ve Meme Kanseri Üçgeni The Triangle of Metformin, Type 2 diabetes mellitus, and the Breast Cancer
Yenmiş, G. (2018) · AYDIN TIP FAKÜLTESİ KLİNİKLERİ DERGİSİ · doi:10.17932/iau.tfk.2018.008/2020.302/tfk_v03i2001 · Cited by 1
Paracelsus Paradox and Drug Repurposing for Cancer
Koltai, T. (2021) · Journal of Oncology Research · doi:10.30564/jor.v3i2.3649 · Cited by 1
Association of the Reduced Function Met420del Polymorphism of SLC22A1 with Metformin-Induced Gastrointestinal Intolerance in Ethiopian Patients with Type 2 Diabetes Mellitus
Degaga, A., Sirgu, S., Huri, H. Z., Sim, M. S., Loganadan, N. K., Kebede, T., Tegene, B., Engidawork, E., & Shibeshi, W. (2024) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s457374 · Cited by 1
The role of AMP-activated protein kinase in myocardial tolerance to ischemia and reperfusion injury in type 2 diabetes mellitus and its relation to metformin therapy
Кравчук, Е. Н., Grineva, E. N., Galagoudza, M. M., Kostareva, A. A., & Bairamov, A. A. (2012) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2012-18-3-206-212 · Cited by 1
State of Knowledge and Recent Advances in Prevention and Treatment of Mitochondrial Dysfunction in Obesity and Type 2 Diabetes
Cantó, C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00017-1 · Cited by 1
The effect of additional acarbose on metformin-associated artificially high 18F-Fluorodeoxyglucose uptake in positron emission tomography/computed tomography
Urhan, E., Temizer, E., Karaca, Z., Abdülrezzak, Ü., Kara, C. Ş., Hacıoğlu, A., & Ünlühızarcı, K. (2022) · Acta Diabetologica · doi:10.1007/s00592-022-01890-3 · Cited by 1
Functional analysis of hepatic FOXO3 signalling in glucose and lipid metabolism
Gul, S. (2014) · OPen Access Repositorium der Universität Ulm (OPARU) (Ulm University) · doi:10.18725/oparu-3289 · Cited by 1
Etude des effets de la metformine et de l’implication de la voie de signalisation mTOR au cours de l’infection par Helicobacter pylori et de la carcinogenèse gastrique
Courtois, S. (2017) · theses.fr (ABES) · doi:10.70675/9cea7a12z80a2z4c42za889z55d1acdfaf97 · Cited by 1
Efectos de los productos de glicación avanzada (AGEs) y la metformina sobre el hueso; estudios in vitro e in vivo
Arnol, V. (2012) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/2765
Effect of mucoadhesive delivery of metformin on the entero-insular axis
Adikwu, M. U., Attama, A. A., & Okorie, O. (2006) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(06)50024-3
Moleculair werkingsmechanisme van metformine: oude of nieuwe inzichten?
Rena, G., Pearson, E. R., & Sakamoto, K. (2013) · Nederlands Tijdschrift voor Diabetologie · doi:10.1007/s12467-013-0061-3
Effects of metformin on human monocytic THP-1 cells - Implications for type 2 diabetes mellitus
Tsuei, A.-C. (2010) · Research Commons (University of Waikato)
DIRECT EFFECTS OF METFORMIN ON PI3K AND RAS SIGNALING IN ENDOMETRIAL CANCER
Iglesias, & David, A. (2012)
Use of Metformin in Clomiphene Citrate (CC) Resistant Polycystic Ovary Syndrome (PCOS)
Begum, M. R., Banu, L. A., Rumana, R., Dewan, F., & Rouf, S. (2009) · Journal of South Asian Federation of Obstetrics and Gynaecology · doi:10.5005/jp-journals-10006-1035
Metformin: A Potential Chemosensitizing Agent for Improving Castration-resistant Prostate Cancer Treatment
Mayer, M. (2016) · TSpace (University of Toronto)
The Impact of Rapamycin and Metformin on Genome Organization and Function in Normal Human Fibroblasts
Gillespie, Z. E. (2016) · University Library - University of Saskatchewan (University of Saskatchewan)
Usage of metformin in patients with type 2 diabetes mellitus
Huang, W. (2016) · UTAS Research Repository · doi:10.25959/23240615
Characterizing the Role of Insulin Signalling in Advanced Prostate Cancer
Sarkar, P. L. (2017) · Queensland University of Technology · doi:10.5204/thesis.eprints.110524
Overcoming Tumor Drug Resistance By Activating Amp-Activated Protein Kinase And Destabilizing Oncoproteins
Shen, M. (2013) · Human Biology
Multiple myeloma: treatment updates.
Berenson, J. R. (2013) · PubMed
Mechanisms of activation and inhibition of the metabolic regulator AMP-activated protein kinase (AMPK)
Dite, T. A. (2018) · Minerva Access (University of Melbourne)
Investigating the Antidiabetic Effect of Metformin on Pyruvate Carboxylase
Solis, G. A. (2019) · Scholarship & Creative Works - Digital UNC a service of University Libraries (University of Northern Colorado)
Metformin modulates glucose uptake and transport in Caco-2 cell monolayers
Thakker, D. R., Bhatt, P. R., Costales, C., Everett, R. S., Alluri, R. V., Wung, D., & Mackowiak, B. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/0czr-eg59
Metformin Pretreatment Rescues Subependymal Zone Neurogenesis and Long-Term Olfactory Memory in a Juvenile Model of Cranial Irradiation
Derkach, D. (2019) · TSpace (University of Toronto)
Efeitos do 17-estradiol e da metformina na captação de glicose, ativação das vias de sinalização de FOXO3a e do receptor de insulina em células ovarianas in vitro
Faria, I. D. S. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2022.tde-28042022-085734
Metformin Inhibit Cell Proliferation and Secretion Function in NCI-H295R CellsPreprint
Li, C., Wang, F., Tong, A., Yan, Z., & Li, Y. (2020) · doi:10.21203/rs.3.rs-26937/v1
Faculty Opinions recommendation of Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.
Morel, C. M. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717978474.793471035
Faculty Opinions recommendation of Once-daily delayed-release metformin lowers plasma glucose and enhances fasting and postprandial GLP-1 and PYY: results from two randomised trials.
Aschner, P. J. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726377451.793538285

Authors: Wilcock, C., & Bailey, C. J.
Affiliations: Aston University (GB)
ORCID: Bailey, C. J.
Venue: Xenobiotica
Publisher: Informa UK Limited
Published: 1994-01
Volume: 24
Issue: 1
Pages: 49-57
ISSN: 0049-8254 (ISSN-L)
1366-5928
DOI: 10.3109/00498259409043220
OpenAlex: W2136667764
Cited by: 418
References: 23
Citations by year: 2026: 6 · 2025: 14 · 2024: 20 · 2023: 23 · 2022: 22 · 2021: 23 · 2020: 21 · 2019: 24 · 2018: 30 · 2017: 31 · 2016: 26 · 2015: 31 · 2014: 30 · 2013: 19 · 2012: 12
FWCI: 2.92
Type: journal article
Language: en
Open access: closed
Locations: Xenobiotica (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: metformin, tissue accumulation, streptozotocin-induced diabetes, small intestine, drug retention, plasma concentration, oral administration, antidiabetic drugs, drug distribution
MeSH terms: Administration, Oral, Animals, Diabetes Mellitus, Experimental, Digestive System, Injections, Intravenous, Male, Metformin, Mice, Inbred Strains, Tissue Distribution, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Accumulation of metformin by tissues of the normal and diabetic mouse

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks