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Cited by 418Pharmacogenetics and Drug MetabolismDiabetes Treatment and ManagementMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Accumulation of metformin by tissues of the normal and diabetic mouse

Wilcock, C., Bailey, C. J.·1994·Xenobiotica
DOI 10.3109/00498259409043220
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Abstract

1. Tissue accumulation of the antihyperglycaemic agent metformin (dimethylbiguanide) was examined after oral administration to the normal and streptozotocin (STZ) diabetic mouse. 2. Metformin (50 mg/kg body weight containing 14C-metformin 25 microCi/kg body weight), which is stable and not metabolized, resulted in maximum plasma concentrations at 0.5 h which declined to < 5% of maximum by 24 h. Maximum plasma concentrations (mumol/l, mean +/- SE) in the hepatic portal vein (normal 51.7 +/- 5.4, STZ 61.5 +/- 8.0) were higher than in the inferior vena cava (normal 29.0 +/- 2.8, STZ 35.4 +/- 5.9). 3. The greatest accumulation of metformin occurred in tissues of the small intestine, where maximum concentrations were > 1000 mumol/kg wet weight at 0.5-2 h, but declined to < 2% of maximum by 24 h. 4. Stomach, colon, salivary gland, kidney and liver accumulated metformin more than two-fold, and concentrations of the drug in heart and skeletal (gastrocnemius) muscle were greater than plasma concentrations on some occasions up to 8 h. 5. In a separate study, i.v.-administered metformin was selectively accumulated by tissues of the small intestine. Thus, retention of metformin by tissues of the small intestine may represent a deep compartment for the drug.

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Crossref · 10.3109/00498259409043220

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Research works printed but not linked: 7

  1. Bailey C. J., 1988, Balliere's Clinical Endocrinology and Metabolism, 2, 455
  2. Bailey C. J., 1986, Diabete et Metabolisme, 12, 212
  3. Cigolini M., 1984, Diabete et Metabolisme, 10, 311
  4. Cohen P. Y., 1961, Therapie, 16, 109
  5. Hermann L. S, 1979, Diabete et Metabolisme, 5, 233
  6. Mordes J. P., 1985, Joslin's Diabetes Mellitus12th edn, 110
  7. Noel M, 1979, Research and Clinical Forums, 1, 35

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Metadata

Authors
Wilcock, C., & Bailey, C. J.
Affiliations
Aston University (GB)
ORCID
Bailey, C. J.
Venue
Xenobiotica
Publisher
Informa UK Limited
Published
1994-01
Volume
24
Issue
1
Pages
49-57
ISSN
  • 0049-8254 (ISSN-L)
  • 1366-5928
DOI
10.3109/00498259409043220
OpenAlex
W2136667764
Cited by
418
References
23
Citations by year
2026: 6 · 2025: 14 · 2024: 20 · 2023: 23 · 2022: 22 · 2021: 23 · 2020: 21 · 2019: 24 · 2018: 30 · 2017: 31 · 2016: 26 · 2015: 31 · 2014: 30 · 2013: 19 · 2012: 12
FWCI
2.92
Type
journal article
Language
en
Open access
closed
Locations
  • Xenobiotica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
metformin, tissue accumulation, streptozotocin-induced diabetes, small intestine, drug retention, plasma concentration, oral administration, antidiabetic drugs, drug distribution
MeSH terms
Administration, Oral, Animals, Diabetes Mellitus, Experimental, Digestive System, Injections, Intravenous, Male, Metformin, Mice, Inbred Strains, Tissue Distribution, Mice

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