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Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use: Effects on Mood and Neuropsychological Function?
Abstract
3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a selective serotonin (5-HT) neurotoxin in animals. There is now preliminary evidence in humans of 5-HT deficits associated with extensive use of MDMA. In order to begin to describe the cognitive and mood effects of chronic MDMA use, nine individuals with extensive MDMA use histories were studied. Despite the absence of memory deficits on clinical examination, a pattern of mild-to-moderate impairment was observed on both the Initial and Delayed Paragraph Tests of the Wechsler Memory Scale; eight of the subjects had at least mild impairment on at least one test in the neuropsychological battery. Despite previously reported suggestive evidence of 5-HT deficit in this group, none reported depressed mood or met clinical criteria for an affective disorder at the time of testing. These preliminary findings raise concern about possible detrimental effects of MDMA use on neuropsychological function for future systematic study and they highlight important issues regarding the effects of 5-HT deficits on cognitive function and mood regulation.
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Citations
Cited by
The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
Green, A. R., Mechan, A. O., Elliott, J. M., O’Shea, E., & Colado, M. I. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.3 · Cited by 1,272
Memory impairment in abstinent MDMA ("Ecstasy") users
Bolla, K. I., McCann, U. D., & Ricaurte, G. A. (1998) · Neurology · doi:10.1212/wnl.51.6.1532 · Cited by 373
Self-citationHuman psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research
Parrott, A. C. (2001) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.351 · Cited by 344
Investigating the neurocognitive deficits associated with chronic drug misuse
Rogers, R. D., & Robbins, T. W. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00204-x · Cited by 344
McCann, U. D., Mertl, M., Eligulashvili, V., & Ricaurte, G. A. (1999) · Psychopharmacology · doi:10.1007/s002130050967 · Cited by 300
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Metadata
- Authors
- Krystal, J. H., Price, L. H., Opsahl, C., Ricaurte, G. A., & Heninger, G. R.
- Venue
- The American Journal of Drug and Alcohol Abuse
- Publisher
- Informa UK Limited
- Published
- 1992-01
- Volume
- 18
- Issue
- 3
- Pages
- 331-341
- ISSN
- 0095-2990 (ISSN-L)
- 1097-9891
- OpenAlex
- W2031549189
- Cited by
- 168
- References
- 0
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use: Effects on Mood and Neuropsychological Function? https://app.cochat.ai/papers/10.3109/00952999209026070
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- Krystal, J. H., Price, L. H., Opsahl, C., Ricaurte, G. A., & Heninger, G. R. (1992). Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use: Effects on Mood and Neuropsychological Function? The American Journal of Drug and Alcohol Abuse. https://doi.org/10.3109/00952999209026070
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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