Sleep Deprivation Reduces Circulating Androgens in Healthy Men
Abstract
The acute effect of sleep deprivation on the pituitary-testis axis was evaluated in 13 healthy men. To study such association, the circulating levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), Androstenedione (A), Testosterone (T), Dihydro-testosterone (DHT) and Estradiol (E2) were measured along with Cortisol (C) before and after sleep deprivation. Morning (8:00 AM) venous blood samples were obtained prior and after a continuous restless period of 24 hr and the values were analyzed by the paired Student's t test. There was a significant and parallel decrease of each androgen and E2 but not of FSH, L.H. PRL, or C, associated with the acute sleep deprivation.
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Observational studies have identified a relationship between total sleep deprivation and reduced testosterone.
“While observational studies have identified a relationship between total sleep deprivation and reduced testosterone [43], [44], only one experimental laboratory based study has investigated the impact of partial sleep restriction on testosterone [45].”
From Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men (2012) · cites this paper as [44]
Cites
Adrenocortical and Gonadal Steroids During Sleep Deprivation
Åkerstedt, T., Palmblad, J., de la Torre, B., Marana, R., & Gillberg, M. (1980) · Sleep · doi:10.1093/sleep/3.1.23 · Cited by 94 · see citing works
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Neuroendocrine Dysfunction in Sleep Apnea: Reversal by Continuous Positive Airways Pressure Therapy*
GRUNSTEIN, R. R., HANDELSMAN, D. J., LAWRENCE, S. J., BLACKWELL, C., CATERSON, I. D., & SULLIVAN, C. E. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-2-352 · Cited by 302 · see citing works
Reynolds, A. C., Dorrian, J., Liu, P. Y., Van Dongen, H. P. A., Wittert, G. A., Harmer, L. J., & Banks, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041218 · Cited by 233 · see citing works
“Research on the relationship between sleep and testosterone has predominantly focused on the effect of total sleep deprivation [43,44,68], or examined the differential effects of sleep stages on testosterone [69–73].”
Background
- Authors
- Cortés-gallegos, V., Castañeda, G., Alonso, R., Sojo, I., Carranco, A., Cervantes, C., & Parra, A.
- Affiliations
- Mexican Social Security Institute (MX)
- ORCID
- Parra, A.
- Venue
- Archives of Andrology
- Publisher
- Informa UK Limited
- Published
- 1983-01
- Volume
- 10
- Issue
- 1
- Pages
- 33-37
- ISSN
- 0148-5016 (ISSN-L)
- OpenAlex
- W2150133858
- Cited by
- 37
- References
- 1
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Andrology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, androgens, testosterone, dihydrotestosterone, androstenedione, estradiol, luteinizing hormone, follicle-stimulating hormone, prolactin, cortisol, healthy men
- MeSH terms
- Adult, Androgens, Follicle Stimulating Hormone, Humans, Hydrocortisone, Luteinizing Hormone, Male, Pituitary Gland, Sleep Deprivation, Dihydrotestosterone, Testis, Testosterone
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