The organisation of collagen fibrils in the human corneal stroma: a synchrotron X-ray diffraction study
Abstract
The low angle equatorial diffraction pattern from the human corneal stroma shows that the collagen fibrils have two preferred orientations: inferior-superior and medial-lateral. We have not observed this effect in any other animal species. This arrangement, which was found to be more pronounced in the posterior than in the anterior stroma, was maintained until the last 1 to 2 millimetres before the limbus at which point uniaxial orientation was observed along the circumference. Our interpretation of this result is that most collagen fibrils wrap around the circumference of the cornea and relatively few continue radially into the limbus where uniformity of collagen fibril diameters is lost.
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Collagen lamellae in the deeper stroma have preferred directions that appear to be close to the inferior-superior and nasal-temporal directions.
“Collagen lamellae in the deeper stroma (Fig. 1a) have preferred directions, which appear to be close to the inferior-superior and nasal-temporal directions (Meek et al., 1987, Aghamohammadzadeh et al., 2004, Abahussin et al., 2009, Kamma-Lorger et al., 2010).”
From Corneal structure and transparency (2015) · cites this paper as Meek et al., 1987
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Corneal structure and transparency
Meek, K. M., & Knupp, C. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.001 · Cited by 853 · see citing works
Self-citationX-Ray Scattering Used to Map the Preferred Collagen Orientation in the Human Cornea and Limbus
Aghamohammadzadeh, H., Newton, R. H., & Meek, K. M. (2004) · Structure · doi:10.1016/j.str.2004.01.002 · Cited by 233 · see citing works
Self-citation
- Authors
- Meek, K. M., Blamires, T., Elliott, G. F., Gyi, T. J., & Nave, C.
- Affiliations
- The Open University (GB)
- Daresbury Laboratory (GB)
- Venue
- Current Eye Research
- Publisher
- Informa UK Limited
- Published
- 1987-01
- Volume
- 6
- Issue
- 7
- Pages
- 841-846
- ISSN
- 0271-3683 (ISSN-L)
- 1460-2202
- OpenAlex
- W2047053579
- Cited by
- 161
- References
- 0
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 11 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 3
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Eye Research (publishedVersion)
- PubMed (publishedVersion)
- Science and Technology Facilities Council (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal Surgery and Treatments
- Keywords
- collagen fibrils, corneal stroma, fibril orientation, low-angle X-ray diffraction, limbus, fibril diameter, human cornea
- MeSH terms
- Aged, Collagen, Cornea, Corneal Stroma, Humans, Middle Aged, Particle Accelerators, X-Ray Diffraction
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