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Culture and Growth Characteristics of Chondrocytes Encapsulated in Alginate Beads
Abstract
Methodology is described for the culture of avian and mammalian chondrocytes in ionotrophically gelled "semi-solid" and "hollow" alginate beads. Chondrocytes grown in "semi-solid" gels exhibited a spherical shape as opposed to a fibroblastic morphology observed in monolayer culture. In the "semi-solid" beads, the cells grew as small clumps and as large aggregates. The aggregates were round or elliptical in appearance and surrounded by a dense Alcian Blue positive halo. Preliminary studies with collagen and chitosan matrixes encapsulated in "hollow" beads suggest that cell growth and morphology are profoundly influenced by the composition of the cellular environment. Chondrocyte structure and function in the "semi-solid" and "hollow" beads were partially characterized by light microscopy, histochemical and biochemical means. The encapsulation methodology is readily applicable for the culture of chondrocytes in single beads, in multiwell dishes, or mass culture.
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Cited by
Technology of mammalian cell encapsulation
Uludag, H., De Vos, P., & Tresco, P. A. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00053-3 · Cited by 601
Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads
Häuselmann, H. J., Fernandes, R. J., Mok, S. S., Schmid, T. M., Block, J. A., Aydelotte, M. B., Kuettner, K. E., & Thonar, E. J.-M. A. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.1.17 · Cited by 533
Injectable gels for tissue engineering
Gutowska, A., Jeong, B., & Jasionowski, M. (2001) · The Anatomical Record · doi:10.1002/ar.1115 · Cited by 441
Chondroitin Sulfate Perlecan Enhances Collagen Fibril Formation
Kvist, A. J., Johnson, A. E., Mörgelin, M., Gustafsson, E., Bengtsson, E., Lindblom, K., Aszódi, A., Fässler, R., Sasaki, T., Timpl, R., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607892200 · Cited by 102
Segar, A. H., Fairbank, J. C. T., & Urban, J. (2019) · European Spine Journal · doi:10.1007/s00586-018-5778-7 · Cited by 101
Metadata
- Authors
- Guo, J., Jourdian, G. W., & Maccallum, D. K.
- Venue
- Connective Tissue Research
- Publisher
- Informa UK Limited
- Published
- 1989-01
- Volume
- 19
- Issue
- 2-4
- Pages
- 277-297
- ISSN
- 0300-8207 (ISSN-L)
- 1607-8438
- OpenAlex
- W2079191512
- Cited by
- 513
- References
- 0
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Guo, J., Jourdian, G. W., & Maccallum, D. K. (1989). Culture and Growth Characteristics of Chondrocytes Encapsulated in Alginate Beads. Connective Tissue Research. https://doi.org/10.3109/03008208909043901
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
