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Cited by 441

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Injectable gels for tissue engineering

Open access
Gutowska, Anna, Jeong, Byeongmoon, Jasionowski, Marek·2001·The Anatomical Record

Abstract

Recently, tissue engineering approaches using injectable, in situ gel forming systems have been reported. In this review, the gelation processes and several injectable systems that exhibit in situ gel formation at physiological conditions are discussed. Applications of selected injectable systems (alginate, chitosan, hyaluronan, polyethylene oxide/polypropylene oxide) in tissue engineering are also described. Injectable polymer formulation can gel in vivo in response to temperature change (thermal gelation), pH change, ionic cross‐linking, or solvent exchange. Kinetics of gelation is directly affected by its mechanism. Injectable formulations offer specific advantages over preformed scaffolds such as: possibility of a minimally invasive implantation, an ability to fill a desired shape, and easy incorporation of various therapeutic agents. Several factors need to be considered before an injectable gel can be selected as a candidate for tissue engineering applications. Apart from tissue‐specific cell–matrix interactions, the following gel properties need to be considered: gelation kinetics, matrix resorption rate, possible toxicity of degradation products and their elimination routes, and finally possible interference of the gel matrix with histogenesis. Anat Rec 263:342–349, 2001. © 2001 Wiley‐Liss, Inc.

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Metadata

Authors
Gutowska, A., Jeong, B., & Jasionowski, M.
Venue
The Anatomical Record
Publisher
Wiley
Published
2001-07-11
Volume
263
Issue
4
Pages
342-349
ISSN
  • 0003-276X (ISSN-L)
  • 1097-0185
OpenAlex
W2086361550
Cited by
441
References
39
FWCI
4.64
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Injectable gels for tissue engineering. https://app.cochat.ai/papers/10.1002/ar.1115
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Gutowska, A., Jeong, B., & Jasionowski, M. (2001). Injectable gels for tissue engineering. The Anatomical Record. https://doi.org/10.1002/ar.1115

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