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Racemization of Aspartic Acid in Human Articular Cartilage
Abstract
The rate of racemization of aspartic acid was measured in young and aged human femoral head cartilage. Normal femoral heads were obtained at postmortem, osteoarthritic specimens at operations for total hip replacement. In order to distinguish between the aspartic acid racemization in collagen from that in proteoglycan (PG), in addition to native tissue, we tested cartilage specimens from which PG had been enzymatically removed. Preliminary results indicate that there is only a very slow collagen turnover in normal adult cartilage. The same is true of residual cartilage from osteoarthritic femoral heads, indicating no rapid repair except where osteophytes are formed. Native, PG-containing cartilage, whether normal or osteoarthritic was found to have unexpectedly high racemization rates.
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Cited by
Effect of Collagen Turnover on the Accumulation of Advanced Glycation End Products
Verzijl, N., DeGroot, J., Thorpe, S. R., Bank, R. A., Shaw, J. N., Lyons, T. J., Bijlsma, J. W. J., Lafeber, F. P. J. G., Baynes, J. W., & TeKoppele, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006700200 · Cited by 963
The Role of Cytokines in Cartilage Matrix Degeneration in Osteoarthritis
Goldring, S. R., & Goldring, M. B. (2004) · Clinical Orthopaedics & Related Research · doi:10.1097/01.blo.0000144854.66565.8f · Cited by 654
Muir, H. (1995) · BioEssays · doi:10.1002/bies.950171208 · Cited by 454
d-Aspartic acid: An endogenous amino acid with an important neuroendocrine role
D'Aniello, A. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.08.005 · Cited by 265
Siadat, S. M., & Ruberti, J. W. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.01.025 · Cited by 87
Metadata
- Authors
- Maroudas, A., Palla, G., & Gilav, E.
- Venue
- Connective Tissue Research
- Publisher
- Informa UK Limited
- Published
- 1992-01
- Volume
- 28
- Issue
- 3
- Pages
- 161-169
- ISSN
- 0300-8207 (ISSN-L)
- 1607-8438
- OpenAlex
- W2127874165
- Cited by
- 159
- References
- 0
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Maroudas, A., Palla, G., & Gilav, E. (1992). Racemization of Aspartic Acid in Human Articular Cartilage. Connective Tissue Research. https://doi.org/10.3109/03008209209015033
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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