CoChat
Sign Up
Cited by 8Digestive system and related healthCeliac Disease Research and ManagementGenetic Associations and Epidemiology

The DOI matches its Crossref record.

Lactase genetic polymorphisms and coeliac disease in children: a cohort study

Kuchay, Raja A. H., Thapa, Babu R., Mahmood, Akhtar, Anwar, Mumtaz, Mahmood, Safrun·2015·Annals of Human Biology
DOI 10.3109/03014460.2014.944216
Open this paper in CoChat — free account

Abstract

Background Lactase activity declines during childhood in the majority of human populations leading to adult-type hypolactasia (AtH). C/T-13910 and G/A-22018 single nucleotide polymorphisms (SNPs) have been suggested to be associated with AtH in different human populations. Coeliac disease (CD) is an autoimmune condition characterized by damage to intestinal cells leading to ultimate deterioration. Aim This study investigated the association between coeliac disease (CD) and SNPs leading to AtH in children from North India. Subjects and methods Intestinal biopsies and saliva samples were obtained from 52 children with CD diagnosis and 102 control subjects. Biopsies were assayed for disaccharidase activities and samples were genotyped for given SNPs. Results Prevalence of C/C and G/G genotypes of AtH was almost equal in the CD and control group. The CD group had low lactase activity compared to the control group, irrespective of genotype at C/T -13910 and G/A -22018 SNPs (p Conclusion There appears to be no significant correlation between C/T -13910 or G/A -22018 SNPs of AtH and CD. Children with C/C or G/G genotype of AtH may not be at greater risk of CD.

Overview

Integrity signals

Registry

Crossref · 10.3109/03014460.2014.944216

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 31

  1. Arola H. 1994. Diagnosis of hypolactasia and lactose malabsorption. Scand J Gastroenterol Suppl 202:26–35 · DOI
  2. 10.1038/ejcn.2012.153 · DOI · Paper page
  3. Bodanszky H, 1987, Acta Paediatr Hung, 28, 45
  4. Bode S, 1988, Scand J Gastroenterol, 23, 484, 10.3109/00365528809093898 · DOI
  5. 10.1080/00365520310000555a · DOI
  6. 10.1089/gte.2004.8.190 · DOI
  7. 10.3109/00365518409161400 · DOI
  8. 10.1038/ng826 · DOI
  9. 10.1056/NEJMra071600 · DOI
  10. 10.1542/peds.2006-1721 · DOI
  11. 10.1007/s00439-006-0291-1 · DOI
  12. 10.1007/BF02703698 · DOI
  13. Kaur K, 2006, Indian J Biochem Biophys, 43, 267
  14. 10.1007/s12263-012-0305-7 · DOI
  15. 10.1016/j.cca.2011.06.032 · DOI
  16. Malterre T, 2009, Altern Med Rev, 14, 247
  17. 10.1016/j.clinbiochem.2008.01.006 · DOI
  18. 10.1542/peds.2008-2373 · DOI
  19. 10.1086/421050 · DOI
  20. 10.1080/00365520701676138 · DOI
  21. 10.1159/000084526 · DOI
  22. 10.1093/hmg/ddg244 · DOI
  23. 10.1046/j.1469-1809.2003.00048.x · DOI
  24. Rasinpera H, Enattah NS, Kuokkanen M, Totterman N, Lindahl H, Jarvela I, Kolho KL. 2004. Genetic test, which can be used to diagnose adult-type hypolactasia in children. Gut 53:1571–1576 · DOI
  25. 10.1016/S0016-5085(97)70031-3 · DOI
  26. 10.1038/sj.ejcn.1602638 · DOI
  27. 10.1146/annurev.genet.37.110801.143820 · DOI
  28. Swallow DM, 2006, Gut, 55, 131
  29. 10.1016/j.bbagen.2005.02.003 · DOI
  30. Usai Satta P, 2008, Gut, 57, 137
  31. 10.1111/j.1572-0241.2007.01471.x · DOI

Cited by

Sorted by citations

Metadata

Authors
Kuchay, R. A. H., Thapa, B. R., Mahmood, A., Anwar, M., & Mahmood, S.
Affiliations
  • Post Graduate Institute of Medical Education and Research (IN)
  • Panjab University (IN)
Corresponding author
Mahmood, Safrun
ORCID
Venue
Annals of Human Biology
Publisher
Informa UK Limited
Published
2014-08-13
Volume
42
Issue
1
Pages
101-104
ISSN
  • 0301-4460 (ISSN-L)
  • 1464-5033
DOI
10.3109/03014460.2014.944216
OpenAlex
W2020106804
Cited by
8
References
0
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Human Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Postgraduate Institute of Medical Education and Research, Chandigarh
  • Department of Biotechnology, Ministry of Science and Technology, India
Topics
  • Health Sciences › Medicine › Gastroenterology › Digestive system and related health
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
celiac disease, adult-type hypolactasia, single nucleotide polymorphisms, lactase activity, disaccharidase activity, children, North India
MeSH terms
Celiac Disease, Child, Child, Preschool, Genotype, Humans, India, Lactose Intolerance, Cohort Studies, Polymorphism, Single Nucleotide, Lactase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review