Central role of mitochondria in drug-induced liver injury
Pessayre, Dominique, Fromenty, Bernard, Berson, Alain, Robin, Marie-Anne, Lettéron, Philippe, Moreau, Richard, Mansouri, Abdellah·2012·Drug Metabolism Reviews
Cites (604)
Items 401–600 of 604
- 3′-Azido-3′-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondriaMatthew D. Lynx, Edward E. McKee · 2006 · Biochemical Pharmacology
- Metabolism of Ticlopidine by Activated Neutrophils: Implications for Ticlopidine-Induced AgranulocytosisZhao Chao Liu, J P Uetrecht · 2000 · Drug Metabolism and Disposition
- Chemotactic activity of hydroxyalkenals on rat neutrophils.M Curzio, Hermann Esterbauer, Dianzani Mu · 1985 · PubMed
- Bioactivation and irreversible binding of the cognition activator tacrine using human and rat liver microsomal preparations. Species difference.Thomas F. Woolf, W F Pool, Susan M. Bjorge, T Chang, O. P. Goel, Claude F. Purchase, Mel C. Schroeder, Kent L. Kunze, William F. Trager · 1993 · Drug Metabolism and Disposition
- Cytochrome P4502B follows a vesicular route to the plasma membrane in cultured rat hepatocytesMarie‐Anne Robin, Michel Maratrat, Jacqueline Loeper, Anne‐Marie Durand‐Schneider, Marina Tinel, François Ballet, Philippe H. Beaune, Gérard Feldmann, Dominique Pessayre · 1995 · Gastroenterology
- Drug Antigenicity, Immunogenicity, and Costimulatory Signaling: Evidence for Formation of a Functional Antigen through Immune Cell MetabolismAyman Elsheikh, Sidonie N. Lavergne, José Luis Castrejón-Flores, John Farrell, Haiyi Wang, Jean G. Sathish, Werner J. Pichler, B. Kevin Park, Dean John Naisbitt · 2010 · The Journal of Immunology
- Autoantibodies Associated with Volatile Anesthetic Hepatitis Found in the Sera of a Large Cohort of Pediatric AnesthesiologistsDolores B. Njoku, Robert S. Greenberg, Mohammed Bourdi · 2002 · Anesthesia & Analgesia
- Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450sBo Wen, Li Ma, Mingshe Zhu · 2008 · Chemico-Biological Interactions
- Assessment of the Contributions of CYP3A4 and CYP3A5 in the Metabolism of the Antipsychotic Agent Haloperidol to Its Potentially Neurotoxic Pyridinium Metabolite and Effect of Antidepressants on the Bioactivation PathwayAmit S.S. Kalgutkar, Timothy J. Taylor, Karthik Venkatakrishnan, Emre Mehmet Isin · 2003 · Drug Metabolism and Disposition
- Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: Implications for gene therapeutic approachesRudolf Thust, Maja T. Tomicic, R. Klöcking, Netta Voutilainen, P Wutzler, Bernd Kaina · 2000 · Cancer Gene Therapy
- Evidence for the Involvement of N-Methylthiourea, a Ring Cleavage Metabolite, in the Hepatotoxicity of Methimazole in Glutathione-Depleted Mice: Structure−Toxicity and Metabolic StudiesTamio Mizutani, Kaoru Yoshida, Mihoko Murakami, Mutsuko Shirai, Sadahiro Kawazoe · 2000 · Chemical Research in Toxicology
- Azathioprine Acts upon Rat Hepatocyte Mitochondria and Stress-Activated Protein Kinases Leading to Necrosis: Protective Role of N-Acetyl-L-cysteineCésar Menor, María Dolores Fernández-Moreno, Jesús Fueyo, Óscar Escribano, Tomás Olleros, Encarna Arriaza, Carlos Cara, Michele Pio Lorusso, Marco Di Paola, Irene D. Román et al. · 2004 · Journal of Pharmacology and Experimental Therapeutics
- Sulindac Metabolism and Synergy with Tumor Necrosis Factor-α in a Drug-Inflammation Interaction Model of Idiosyncratic Liver InjuryWei Zou, Kevin M. Beggs, Erica Sparkenbaugh, A. Daniel Jones, Husam S. Younis, Robert A. Roth, Patricia E. Ganey · 2009 · Journal of Pharmacology and Experimental Therapeutics
- Induction of endoplasmic reticulum stress by ellipticine plant alkaloidsMaria Hägg, Maria Berndtsson, Aleksandra Mandic, Rong Zhou, Maria Caspar Shoshan, Stig T. Linder · 2004 · Molecular Cancer Therapeutics
- Valproate-induced hepatic failure in a case of cytochrome?c oxidase deficiencyB. Chabrol, Josette Mancini, Dominique Chrétien, Pierre Rustin, Arnold Münnich, Nicole Pinsard · 1994 · European Journal of Pediatrics
- Irreversible protein binding of [14C]imipramine with rat and human liver microsomesHermann Kappus, Herbert Remmer · 1975 · Biochemical Pharmacology
- In Vitro Metabolism of a Model Cyclopropylamine to Reactive Intermediate: Insights into Trovafloxacin-Induced HepatotoxicityQin Sun, Ran Zhu, Frank W. Foss, Timothy L. Macdonald · 2008 · Chemical Research in Toxicology
- Metabolic, idiosyncratic toxicity of drugs: overview of the hepatic toxicity induced by the anxiolytic, panadiplonRoger G. Ulrich, James A. Bacon, Eric P. Brass, Clay T. Cramer, Diane K. Petrella, Elena L Sun · 2001 · Chemico-Biological Interactions
- In Vitro Assessment of RiskNeil H. Shear, Stephen P. Spielberg, MARGARET ANN MILLER · 1988
- Nuclear power and mitochondrial diseaseSalvatore DiMauro, Eric A. Schon · 1998 · Nature Genetics
- Irreversible Sensorineural Hearing Loss as a Result of Azithromycin OtotoxicityBradford D. Ress, Eric M. Gross · 2000 · Annals of Otology Rhinology & Laryngology
- Mitochondrial damage in adipose tissue of untreated HIV-infected patientsGlòria Garrabou, Sònia López, Constanza Morén, Estebán Martínez, Joan Fontdevila, Francesc Cardellach, Josep Maria Gatell, Òscar Miró · 2010 · AIDS
- Pyrimidine Nucleoside Depletion Sensitizes to the Mitochondrial Hepatotoxicity of the Reverse Transcriptase Inhibitor StavudineBernhard Setzer, Dirk Lebrecht, Ulrich Andreas Walker · 2008 · American Journal Of Pathology
- Hepatotoxicity and metabolism of iproniazid and isopropylhydrazine.Sidney D. Nelson, J R Mitchell, Wayne R. Snodgrass, John A. Timbrell · 1978 · Journal of Pharmacology and Experimental Therapeutics
- Genetic dimorphism in superoxide dismutase and susceptibility to alcoholic cirrhosis, hepatocellular carcinoma, and deathPierre Nahon, Angéla Sutton, Dominique Pessayre, Pierre Rufat, Françoise Degoul, Nathalie Ganne‐Carrié, Marianne Ziol, Nathalie Charnaux, G. Nkontchou, Jean–Claude Trinchet et al. · 2005 · Clinical Gastroenterology and Hepatology
- Inborn errors of metabolism in children referred with Reye's syndrome. A changing patternP. C. Rowe · 1988 · JAMA
- Induction of apoptosis by enediyne antibiotic calicheamicin ϑII proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent mannerAram Prokop, Wolf Wrasidlo, Holger N. Lode, Ralf Herold, Florian J.W. Lang, Günter Henze, Bernd Dörken, Thomas Wieder, Peter T. Daniel · 2003 · Oncogene
- Withdrawal of life support, altruistic suicide, fratricidal killing and euthanasia by lymphocytes: different forms of drug-induced hepatic apoptosisDominique Pessayre, D. Haouzi, Daniel Fau, Marie Anne Robin, Abdellah Mansouri, Alain Berson · 1999 · Journal of Hepatology
- Suicide inactivation of rat liver cytochrome P-450 by chloramphenicol in vivo and in vitro.James R. Halpert, Birgitta Näslund, Ingvar Betnér · 1983 · Molecular Pharmacology
- Letters to the EditorFrançois Gilles Brivet, Isabelle Nion–Larmurier, Bruno Mégarbane, Abdelhamid Slama, M. Brivet, Pierre Rustin, Arnold Münnich · 2000 · Journal of Hepatology
- Drug‐Induced Liver InjuryDominique Pessayre, Dominique G. Larrey · 2007 · Wiley eBooks
- Evaluation of human blood lymphocytes as a model to study the effects of drugs on human mitochondriaBernard Fromenty, Philippe Lettéron, Cécile Fisch, Alain Berson, Dominique Deschamps, Dominique Pessayre · 1993 · Biochemical Pharmacology
- Bioactivation of Lumiracoxib by Peroxidases and Human Liver Microsomes: Identification of Multiple Quinone Imine Intermediates and GSH AdductsPing Kang, Deepak Dalvie, Evan Smith, Matt Renner · 2008 · Chemical Research in Toxicology
- PROTEIN-REACTIVE METABOLITES OF CARBAMAZEPINE IN MOUSE LIVER MICROSOMESJames H. Lillibridge, Benny M. Amore, John T. Slattery, T F Kalhorn, Sidney D. Nelson, Richard H. Finnell, G.D. Bennett · 1996 · Drug Metabolism and Disposition
- Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione.Dominique Pessayre, Marina Tinel, Dominique G. Larrey, Barton Cobert, Christian Funck‐Brentano, G Babany · 1983 · Journal of Pharmacology and Experimental Therapeutics
- Mitochondrial DNA metabolism targeting drugsThomas C. Rowe, Volkmar Weissig, Jeffrey W. Lawrence · 2001 · Advanced Drug Delivery Reviews
- Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4Amit S.S. Kalgutkar, Kirk R. Henne, Mary E. Lame, Alfin D. N. Vaz, Claire Collin, John R. Soglia, Sabrina X. Zhao, Cornelis E. C. A. Hop · 2005 · Chemico-Biological Interactions
- Pentamidine inhibits mitochondrial intron splicing and translation in Saccharomyces cerevisiaeYi Zhang, Achim Bell, Philip S. Perlman, Michael J. Leibowitz · 2000 · RNA
- Jaundice associated with naproxenRui M. M. Victorino, José Carlos Bruno da Silveira, A Baptista, M C de Moura · 1980 · Postgraduate Medical Journal
- The Anti-Inflammatory Drug, Nimesulide (4-Nitro-2-phenoxymethane-sulfoanilide), Uncouples Mitochondria and Induces Mitochondrial Permeability Transition in Human Hepatoma Cells: Protection by AlbuminAlain Berson, Sophie C. Cazanave, Véronique Descatoire, Marina Tinel, Alain Grodet, Claude Wolf, Gérard Feldmann, Dominique Pessayre · 2006 · Journal of Pharmacology and Experimental Therapeutics
- Salicylate Enhances Necrosis and Apoptosis Mediated by the Mitochondrial Permeability TransitionKi‐Wan Oh · 2003 · Toxicological Sciences
- Mechanism of action of the nitrosoureas—IVCharles T. Gombar, William P. Tong, David B. Ludlum · 1980 · Biochemical Pharmacology
- Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450sBo Wen, Mingyan Zhou · 2009 · Chemico-Biological Interactions
- Flavin-containing monooxygenase-mediated metabolism of N-deacetyl ketoconazole by rat hepatic microsomes.Russell J. Rodriguez, Philip Proteau, Brian L. Márquez, Clive Hetherington, Cheryl J. Buckholz, Kerry L. O’Connell · 1999 · PubMed
- Uridine in the Prevention and Treatment of Nrti-Related Mitochondrial ToxicityUlrich Andreas Walker, Nils Venhoff · 2005 · Antiviral Therapy
- Pirprofen-induced fulminant hepatitisGaby Danan, P Trunet, Jacques Bernuau, Claude Degott, G Babany, Dominique Pessayre, BERNARD RUEFF, J.P. Benhamou · 1985 · Gastroenterology
- Cytotoxic activity of T cells and non-T cells from diclofenac-immunized mice against cultured syngeneic hepatocytes exposed to diclofenacAnke Kretz-Rommel, Urs Alex Boelsterli · 1995 · Hepatology
- Polymorphism T → C (−34 base pairs) of gene CYP17 promoter in women with polycystic ovary syndrome is associated with increased body weight and insulin resistance: a preliminary studyBárbara Echiburú, Francisco Pérez‐Bravo, Manuel Alejandro Maliqueo, Fernando Sánchez, Nicolás Crisosto, Teresa Sir‐Petermann · 2008 · Metabolism
- Mitochondrial dysfunction and delayed hepatotoxicity: another lesson from troglitazoneNeil L. Julie, I. M. Julie, A. I. Kende, G. Lee Wilson · 2008 · Diabetologia
- Induction and inhibition of hepatic drug metabolizing enzymes by rifampinDominique Pessayre, Paul Mazel · 1976 · Biochemical Pharmacology
- Tetrandrine-induced apoptosis in rat primary hepatocytes is initiated from mitochondria: Caspases and Endonuclease G (Endo G) pathwayCai Yan, Xinming Qi, Gong Li-Kun, Linlin Liu, Chen Fang-ping, Xiao Ying, Xiongfei Wu, Xianghong Li, Ren Jin · 2005 · Toxicology
- Role of benoxaprofen and flunoxaprofen acyl glucuronides in covalent binding to rat plasma and liver proteins in vivoJennifer Q. Dong, Jianhua Liu, Philip C. Smith · 2005 · Biochemical Pharmacology
- Prediction of drug-induced liver injury in humans by using in vitro methods: The case of ximelagatranKerstin Kenne, Inger Skånberg, Björn Glinghammar, Alain Berson, Dominique Pessayre, Jean-Pierre Flinois, Philippe H. Beaune, Irene Edebert, Cecilia Diaz Pohl, Stefan Carlsson et al. · 2007 · Toxicology in Vitro
- Uridine supplementation antagonizes zalcitabine-induced microvesicular steatohepatitis in miceDirk Lebrecht, Yetlanezi A. Vargas-Infante, Bernhard Setzer, Janbernd Kirschner, Ulrich Andreas Walker · 2006 · Hepatology
- Studies on 5,5-diphenylhydantoin irreversible binding to rat liver microsomal proteinsClaudio Pantarotto, Margarita Arboix, P. Sezzano, R. Abbruzzi · 1982 · Biochemical Pharmacology
- Oxidative metabolism of hydralazine. Evidence for nitrogen centered radicals formationBirandra Kumar Sinha, Ann G. Motten · 1982 · Biochemical and Biophysical Research Communications
- Disulfiram metabolism as a requirement for the inhibition of rat liver mitochondrial low Km aldehyde dehydrogenaseJeffrey J. Yourick, Morris D. Faiman · 1991 · Biochemical Pharmacology
- Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiencyMichael Kottlors, Michaela Jaksch, Uwe‐Peter Ketelsen, Stefan Markus Weiner, Franz Xaver Glocker, Carl-Hermann Lücking · 2001 · Neuromuscular Disorders
- Chemical reactivity of the naproxen acyl glucuronide and the naproxen coenzyme A thioester towards bionucleophilesJørgen Olsen, Inga Bjørnsdottir, Jette Tjørnelund, Steen Honoré Hansen · 2002 · Journal of Pharmaceutical and Biomedical Analysis
- Lymphocyte reactivity to ex-vivo drug antigens in drug-induced hepatitisVasco A. J. Maria, Lígia A. Pinto, Rui M. M. Victorino · 1994 · Journal of Hepatology
- Effect of valproic acid treatment on body composition, leptin and the soluble leptin receptor in epileptic childrenMarkus Rauchenzauner, Edda Haberlandt, Sabine Scholl‐Bürgi, Daniela Karall, Elisabeth Schoenherr, T. Tatarczyk, Julia Engl, Markus Wolfgang Laimer, Gerhard J. Luef, Christoph F. Ebenbichler · 2008 · Epilepsy Research
- The Content of Intracellular Mitochondrial DNA Is Decreased by 1-Methyl-4-phenylpyridinium Ion (MPP+)Kenichi Miyako, Yoichiro Kai, Takashi Irie, Koichiro Takeshige, Dongchon Kang · 1997 · Journal of Biological Chemistry
- Carbon tetrachloride and 2-isopropyl-4-pentenamide-induced inactivation of cytochrome P-450 leads to heme-derived protein adductsHelen W. Davies, Steven G. Britt, Lance R. Pohl · 1986 · Archives of Biochemistry and Biophysics
- Impaired tetramer assembly of variant medium-chain acyl-coenzyme A dehydrogenase with a glutamate or aspartate substitution for lysine 304 causing instability of the protein.Ichiro Yokota, Takahiko Saijo, Jerry E. Vockley, Kay Tanaka · 1992 · Journal of Biological Chemistry
- Physiological Role of the N-terminal Processed P4501A1 Targeted to Mitochondria in Erythromycin Metabolism and Reversal of Erythromycin-mediated Inhibition of Mitochondrial Protein SynthesisHindupur K. Anandatheerthavarada, Camasamudram Vijayasarathy, Shripad V. Bhagwat, Gopa Biswas, Jayati Mullick, Narayan G. Avadhani · 1999 · Journal of Biological Chemistry
- The participation of pyridine nucleotides redox state and reactive oxygen in the fatty acid‐induced permeability transition in rat liver mitochondriaRosana Catisti, Aníbal Eugênio Vercesi · 1999 · FEBS Letters
- Bioactivation of Tamoxifen by Recombinant Human Cytochrome P450 EnzymesLisa M. Notley, Cornelia J. F. de Wolf, Rebecca M. Wunsch, Roy G. Lancaster, Elizabeth M. J. Gillam · 2002 · Chemical Research in Toxicology
- Bioactivation of Clozapine by Murine Cardiac Tissue in Vivo and in VitroDominic P. Williams, Charles J. L. O'Donnell, James L. Maggs, James Steven Leeder, Jack Uetrecht, Munir Pirmohamed, B. Kevin Park · 2003 · Chemical Research in Toxicology
- Metabolism of [3-14C]coumarin to polar and covalently bound products by hepatic microsomes from the rat, syrian hamster, gerbil and humansBrian G. Lake, H. Gaudin, Roger J. Price, D.G. Walters · 1992 · Food and Chemical Toxicology
- Tumor Necrosis Factorα Is a Proximal Mediator of Synergistic Hepatotoxicity from Trovafloxacin/Lipopolysaccharide CoexposurePatrick J. Shaw, Patricia E. Ganey, Robert A. Roth · 2008 · Journal of Pharmacology and Experimental Therapeutics
- CASE REPORT: Trovafloxacin HepatotoxicityDariusz A. Lazarczyk, Neal S. Goldstein, Stuart C. Gordon · 2001 · Digestive Diseases and Sciences
- Valproate inhibits the mitochondrial pyruvate‐driven oxidative phosphorylation in vitroMargarida F. B. Silva, Jos P.N. Ruiter, Lodewijk IJlst, Cornelis Jakobs, Marinus Durán, Isabel Tavares de Almeida, Ronald J. A. Wanders · 1997 · Journal of Inherited Metabolic Disease
- Autoxidative formation of a chemically reactive intermediate from amodiaquine, a myelotoxin and hepatotoxin in manJames L. Maggs, N.R. Kitteringham, AM Breckenridge, B.K. Park · 1987 · Biochemical Pharmacology
- Immunochemical detection of flucloxacillin adduct formation in livers of treated ratsMichelle A. Carey, Frank N.A.M. van Pelt · 2005 · Toxicology
- Enhanced Susceptibility of HLA-mediated Ticlopidine-induced Idiosyncratic Hepatotoxicity by CYP2B6 Polymorphism in JapaneseNoritaka Ariyoshi, Yukako Iga, Koji Hirata, Yasunori Sato, Go Miura, Itsuko Ishii, Seiji Nagamori, Mitsukazu Kitada · 2010 · Drug Metabolism and Pharmacokinetics
- CYP2C9-Mediated Metabolic Activation of Losartan Detected by a Highly Sensitive Cell-Based Screening AssayAtsushi Iwamura, Tatsuki Fukami, Hiroko Hosomi, Miki Nakajima, Tsuyoshi Yokoi · 2011 · Drug Metabolism and Disposition
- Protein kinase PKC delta and c‐Abl are required for mitochondrial apoptosis induction by genotoxic stress in the absence of p53, p73 and Fas receptorMalika Lasfer, Lise Davenne, Nathalie Vadrot, Catherine Alexia, Zahia Sadji-Ouatas, A.F. Bringuier, Gérard Feldmann, Dominique Pessayre, Florence Reyl-Desmars · 2006 · FEBS Letters
- Protective effect of bicyclol on tetracycline-induced fatty liver in miceHongyan Yu, Baolian Wang, Jian Zhao, Xiaomin Yao, Yu Gu, Yan Li · 2009 · Toxicology
- Genetic predisposition to drug hepatotoxicity: Role in hepatitis caused by amineptine, a tricyclic antidepressantDominique G. Larrey, Alain Berson, François Habersetzer, Marina Tinel, A Castot, G Babany, Philippe Lettéron, Eric Fréneaux, Jacqueline Loeper, Patrick M. Dansette et al. · 1989 · Hepatology
- Mitochondrial injury by disulfiram: two different mechanisms of the mitochondrial permeability transitionMaxim Y. Balakirev, Guido Zimmer · 2001 · Chemico-Biological Interactions
- Amineptine, a tricyclic antidepressant, inhibits the mitochondrial oxidation of fatty acids and produces microvesicular steatosis of the liver in mice.Tim Dinh, Eric Fréneaux, Gilles Labbe, Philippe Lettéron, Claude Degott, Jean Genève, Alain Berson, Dominique G. Larrey, Dominique Pessayre · 1988 · Journal of Pharmacology and Experimental Therapeutics
- Effects of various tetracycline derivatives on in vitro and in vivo β-oxidation of fatty acids, egress of triglycerides from the liver, accumulation of hepatic triglycerides, and mortality in miceGilles Labbe, Bernard Fromenty, Eric Fréneaux, Veronique Morzelle, Philippe Lettéron, Alain Berson, Dominique Pessayre · 1991 · Biochemical Pharmacology
- Liver Failure Caused by Herpes Simplex Virus Thymidine Kinase Plus Ganciclovir Therapy Is Associated with Mitochondrial Dysfunction and Mitochondrial DNA DepletionMaite Herráiz, Naiara Beraza, Abelardo Solano, Bruno Sangro, Julio Montoya, Cheng Qian, Jesús Prìeto, Matilde Bustos · 2003 · Human Gene Therapy
- R964C Mutation of DNA Polymerase γ Imparts Increased Stavudine Toxicity by Decreasing Nucleoside Analog Discrimination and Impairing Polymerase ActivityChristopher M. Bailey, Rajesh Kasiviswanathan, William C. Copeland, Karen S. Anderson · 2009 · Antimicrobial Agents and Chemotherapy
- Mechanism of action of the nitrosoureas—1William P. Tong, David B. Ludlum · 1978 · Biochemical Pharmacology
- In situ formation of the acetaminophen metabolite covalently bound in kidney and lung Supportive evidence provided by total hepatectomyBreen, Kerry, Joao-Carlos, Wandscheer, Peignoux, Michelle, Pessayre, Dominique · 1982 · Biochemical Pharmacology
- Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-.ALPHA.) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytesAdarsh S. Gandhi, Tao Guo, Romi Ghose · 2010 · The Journal of Toxicological Sciences
- Frequency of Medium-Chain Acyl-CoA Dehydrogenase Deficiency G-985 Mutation in Sudden Infant Death SyndromeMarvin E. Miller, John Graham Brooks, Nicholas T. Forbes, Richard A. Insel · 1992 · Pediatric Research
- Regulation of mitochondrial mRNA stability by RNase L is translation-dependent and controls IFNα-induced apoptosisFlorence Le Roy, Michèle Silhol, Tamim Salehzada, Catherine Bisbal · 2007 · Cell Death and Differentiation
- Fatty Liver and Pleural Effusion with Ibuprofen TherapyJaime F. Bravo, MICHAEL P. JACOBSON, BENNY F. MERTENS · 1977 · Annals of Internal Medicine
- Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic ToxicophoreEmma E. Graham, Rachel J. Walsh, Charlotte M. Hirst, James L. Maggs, Scott W. Martin, Martin J. Wild, Ian D. Wilson, John Harding, J. Gerry Kenna, Raimund M. Peter et al. · 2008 · Journal of Pharmacology and Experimental Therapeutics
- Antibody mediated hepatocyte injury in methyl dopa induced hepatotoxicity.James Neuberger, J. Gerald Kenna, K T Nouri Aria, Roger L. Williams · 1985 · Gut
- Treatment with Antimalarials Adversely Affects the Oxidative Energy Metabolism in Rat Liver MitochondriaSubhash D. Katewa, Surendra S. Katyare · 2004 · Drug and Chemical Toxicology
- In Vitro Nimesulide Studies toward Understanding Idiosyncratic Hepatotoxicity: Diiminoquinone Formation and ConjugationFengping Li, Mahendra D. Chordia, Tao Huang, Timothy L. Macdonald · 2008 · Chemical Research in Toxicology
- Does early diagnosis and delivery in acute fatty liver of pregnancy lead to improvement in maternal and infant survival?E C Ebert, E. A. Sun, S. Wright, John P. Decker, Ronald J. Librizzi, Ronald J. Bolognese, William H. Lipshutz · 1984 · Digestive Diseases and Sciences
- DNA topoisomerase II from mammalian mitochondria is inhibited by the antitumor drugs, m-AMSA and VM-26Jia‐Hwei Lin, Frank J. Castora · 1991 · Biochemical and Biophysical Research Communications
- A Comparison of Liver Ultrastructure in Salicylate Intoxication and Reye’s SyndromeJacqueline S. Partin, Cynthia C. Daugherty, James A. Mcadams, John C. Partin, William K. Schubert · 1984 · Hepatology
- Markers of Electrophilic Stress Caused by Chemically Reactive Metabolites in Human HepatocytesHideo Takakusa, Hiroshi Masumoto, Ayako Mitsuru, Osamu Okazaki, Kenichi Sudo · 2008 · Drug Metabolism and Disposition
- Ethanol down‐regulates the transcription of microsomal triglyceride transfer protein geneMarie Chia-mi Lin, Jian Jian Li, Erjia Wang, Gerald L. Princler, Frederick C. Kauffman, Hsiang‐Fu Kung · 1997 · The FASEB Journal
- Uridine supplementation enhances hepatic mitochondrial function in thymidine-analogue treated HIV-infected patientsMatthias Banasch, Oliver Goetze, K Knyhala, Anja Potthoff, Renate Schlottmann, Monika A. Kwiatek, Kerem Bulut, Frank Schmitz, Wolfgang Ekkehard Schmidt, Norbert Hermann Brockmeyer · 2006 · AIDS
- A role for IRF3-dependent RXRα repression in hepatotoxicity associated with viral infectionsEdward Kai‐Hua Chow, Antonio Castrillo, Arash Shahangian, Liming Pei, Ryan M. O’Connell, Robert L. Modlin, Peter Tontonoz, Genhong Cheng · 2006 · The Journal of Experimental Medicine
- Enzyme-Mediated Protein Haptenation of Dapsone and Sulfamethoxazole in Human Keratinocytes: I. Expression and Role of Cytochromes P450Piyush M. Vyas, Sanjoy Roychowdhury, Farah D. Khan, Thomas Edward Prisinzano, Jatinder Kaur Lamba, Erin G. Schuetz, Joyce A. Blaisdell, Joyce A. Goldstein, Kimber L. Munson, Ronald N. Hines et al. · 2006 · Journal of Pharmacology and Experimental Therapeutics
- Generation of free radicals during the reductive metabolism of the nitroaromatic compound, nilutamide.Alain Berson, Claude Wolf, Virginie Berger, Daniel Fau, Claude Chachaty, Bernard Fromenty, Dominique Pessayre · 1991 · Journal of Pharmacology and Experimental Therapeutics
- Large hepatic mitochondrial DNA deletions associated with l-lactic acidosis and highly active antiretroviral therapyPaul B. Bartley, L Westacott, Robert James Boots, Margaret Lawson, Julia M. Potter, V.J. Hyland, Marion L. Woods · 2001 · AIDS
- Disposition and covalent binding of diflunisal and diflunisal acyl glucuronide in the isolated perfused rat liver.Min Wang, RONALD G. DICKINSON · 1998 · PubMed
- Effects of pregnancy on the toxicity and metabolism of acetaminophen in mice.Dominique G. Larrey, Philippe Lettéron, Armelle Foliot, Véronique Descatoire, Claude Degott, Jean Genève, Marina Tinel, Dominique Pessayre · 1986 · Journal of Pharmacology and Experimental Therapeutics
- Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermatesIsabelle Larosche, Amal Choumar, Bernard Fromenty, Philippe Lettéron, Adjé Abbey‐Toby, Holly Van Remmen, Charles J. Epstein, Arlan G Richardson, Gérard Feldmann, Dominique Pessayre et al. · 2008 · Toxicology and Applied Pharmacology
- Procainamide, a Drug Causing Lupus, Induces Prostaglandin H Synthase-2 and Formation of T Cell-Sensitizing Drug Metabolites in Mouse MacrophagesCarsten Goebel, Christoph F. A. Vogel, Marty Wulferink, Stephanie G. Mittmann, Bernhardt Sachs, Sabine Schraa, Josef Abel, Gisela H. Degen, Jack Uetrecht, Ernst Gleichmann · 1999 · Chemical Research in Toxicology
- In vitro irreversible binding of ketoprofen glucuronide to plasma proteins.Nathalie Presle, Fran�oise Lapicque, M H Maurice, Michael P. Pritchard, Sylvie Fournel‐Gigleux, Jacques Magdalou, Michel Abiteboul, Gérard Siest, Patrick Netter · 1993 · Drug Metabolism and Disposition
- T Cells Ignore the Parent Drug Propylthiouracil but Are Sensitized to a Reactive Metabolite Generatedin VivoS. von Schmiedeberg, Ulrike Hanten, Carsten Goebel, Hans‐Christian Schuppe, Jack Uetrecht, Ernst Gleichmann · 1996 · Clinical Immunology and Immunopathology
- Metabolism of aromatic amines by prostaglandin H synthase.Jeff A. Boyd, Thomas E. Eling · 1985 · Environmental Health Perspectives
- Metabolic activation of the tricyclic antidepressant amineptine—IJean Genève, Dominique G. Larrey, Philippe Lettéron, Véronique Descatoire, Marina Tinel, Gilles Amouyal, Dominique Pessayre · 1987 · Biochemical Pharmacology
- Apoptosis and Its Modulation by Drugs2000 · Handbook of experimental pharmacology
- Impairment of mitochondrial function by minocyclineKathleen Kupsch, Silvia Hertel, Peter Kreutzmann, Gerald L Wolf, Claus-Werner Wallesch, Detlef Siemen, Peter Schönfeld · 2009 · FEBS Journal
- Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytesSudipta Saha, Lee Sun New, Han Kiat Ho, Wai Keung Chui, Eric Chun Yong Chan · 2010 · Toxicology Letters
- Influence of acetaminophen at therapeutic doses on surrogate markers of severity of acute viral hepatitisCésar Yaghi, Khalil Honein, Joseph Boujaoudé, R. Slim, Rami Moucari, Raymond Sayegh · 2006 · Gastroentérologie Clinique et Biologique
- Glutathione synthetase–deficient lymphocytes and acetaminophen toxicityStephen P. Spielberg, Gary Gordon · 1981 · Clinical Pharmacology & Therapeutics
- Analysis of methylglyoxal bis(guanylhydrazone)-induced alterations of hamster tumor mitochondria by correlated studies of selective rhodamine binding, ultrastructural damage, DNA replication, and reversibility.Margit M. K. Nass · 1984 · PubMed
- Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in miceTerry G. J. Derks, Theo H. van Dijk, Aldo Grefhorst, J. P. Rake, Peter G. A. Smit, Folkert Kuipers, Dirk‐Jan Reijngoud · 2008 · Hepatology
- Evidence that the biotransformation of dapsone and monoacetyldapsone to their respective hydroxylamine metabolites in rat liver microsomes is mediated by cytochrome P450 2C6/2C11 and 3A1.Chandravathi Vage, Craig K. Svensson · 1994 · Drug Metabolism and Disposition
- DNA repair in mammalian mitochondria: much more than we thought? Environ Mol MutagenPingfang Liu, Bruce Demple · 2010
- Genetic polymorphisms in the 5′-flanking region of human UDP-glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulationAkiko Nakamura, Miki Nakajima, Eriko Higashi, Hiroyuki Yamanaka, Tsuyoshi Yokoi · 2008 · Pharmacogenetics and Genomics
- Medium chain acyl-CoA dehydrogenase deficiency and fatal valproate toxicityPål R. Njølstad, Ola H. Skjeldal, Etienne Agsteribbe, Anke L. W. Huckriede, Ebba Wannag, Oddmund Sövik, Per Erik Waaler · 1997 · Pediatric Neurology
- Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosisSang‐Kyu Lee, Yong Chan Kim, Seok Bean Song, Young Sang Kim · 2009 · Biochemical and Biophysical Research Communications
- Effect of thiazolidinediones on bile acid transport in rat liverKris L. Snow, Richard H. Moseley · 2006 · Life Sciences
- Human microsomal N-oxidative metabolism of cocaine.Stephen M. Roberts, Raymond D. Harbison, R C James · 1991 · Drug Metabolism and Disposition
- HLA-A33/B44/DR6 Is Highly Related to Intrahepatic Cholestasis Inducedby TioproninMariko Kurosaki, Hitoshi Takagi, Masatomo Mori · 2000 · Digestive Diseases and Sciences
- Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.Shosaku Noda, Hirotoshi Umezaki, Katsuhiko Yamamoto, T Araki, T Murakami, Nobuyoshi Ishii · 1988 · Journal of Neurology Neurosurgery & Psychiatry
- Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N‐terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae − role of protein kinase A in the mitochondrial targeting of CYP2E1Naresh Babu V. Sepuri, Sanjay Yadav, Hindupur K. Anandatheerthavarada, Narayan G. Avadhani · 2007 · FEBS Journal
- ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overloadJoel Castro, Iván Ruminot, Omar H. Porras, C M Flores, Tamara Hermosilla, E Verdugo, Fabiola Venegas, Steffen Härtel, Luis Michea, L. Felipe Barros · 2006 · Cell Death and Differentiation
- Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicityDaniel F. Carr, Ana Alfirevic, Jonathan D. Tugwood, Bryan J. Barratt, James L. Sherwood, John Morrison Smith, Munir Pirmohamed, B. Kevin Park · 2007 · Pharmacogenetics and Genomics
- The metabolic pathways of tianeptine, a new antidepressant, in healthy volunteers.L. Grislain, Patrick Gelé, Marc Bertrand, Wim Luijten, Norbert Bromet, C. Salvadori, Annie Kamoun · 1990 · Drug Metabolism and Disposition
- Morphologic studies on secondary phospholipidosis in human liver.Felix A. de la Iglesia, George M. Feuer, Atsushi Takada, Y Matsuda · 1974 · PubMed
- Coordination chemistry of cytochromes P 450 and iron-porphyrins: relevance to pharmacology and toxicologyDaniel Mansuy · 1978 · Biochimie
- Subliminal Fas stimulation increases the hepatotoxicity of acetaminophen and bromobenzene in miceMarina Tinel, Alain Berson, Nathalie Vadrot, Véronique Descatoire, Alain Grodet, Gérard Feldmann, Jean Paul Thénot, Dominique Pessayre · 2004 · Hepatology
- Metabolic and Chemical Origins of Cross-Reactive Immunological Reactions to Arylamine Benzenesulfonamides: T-Cell Responses to Hydroxylamine and Nitroso DerivativesJosé Luis Castrejón-Flores, Sidonie N. Lavergne, Ayman El-Sheikh, John Farrell, James L. Maggs, Sunil Sabbani, Paul M. O’Neill, B. Kevin Park, Dean John Naisbitt · 2009 · Chemical Research in Toxicology
- 2-ABT-S-oxide detoxification by glutathioneS-transferases A1-1, M1-1 and P1-1: Implications for toxicity associated with zileutonElizabeth Joshi, Brian H. Heasley, Timothy L. Macdonald · 2009 · Xenobiotica
- NADH-dependent microsomal interaction with ferric complexes and production of reactive oxygen intermediatesEwa Kukielka, Arthur I. Cederbaum · 1989 · Archives of Biochemistry and Biophysics
- Hepatocyte Apoptosis Triggered by Natural Substances (Cytokines, Other Endogenous Molecules and Foreign Toxins)Dominique Pessayre, Gérard Feldmann, D. Haouzi, Daniel Fau, A. Moreau, Manuela G. Neuman · 2000 · Handbook of experimental pharmacology
- CASE REPORT: Myositis, Microvesicular Hepatitis, and Progression to Cirrhosis from Troglitazone Added to SimvastatinStephen Hugh Caldwell, Elizabeth Erickson Hespenheide, Reid W. von Borstel · 2001 · Digestive Diseases and Sciences
- Amitriptyline metabolites in human urine. Identification of phenols, dihydrodiols, glycols, and ketones.Axel Prox, Ursula Breyer-Pfaff · 1987 · Drug Metabolism and Disposition
- Chronic active hepatitis caused by benzaroneBabany, Gérard, Larrey, Dominique, Pessayre, Dominique, Degott, Claude, Rueff, Bernard, Benhamou, Jean-Pierre · 1987 · Journal of Hepatology
- Nifurtimox biotransformation to reactive metabolites or nitrite in liver subcellular fractions and model systemsM. Montalto de Mecca, Edith G. Díaz, J.A. Castro · 2002 · Toxicology Letters
- Mechanisms of Chloroform-Induced Hepatotoxicity: Oxidative Stress and Mitochondrial Permeability Transition in Freshly Isolated Mouse HepatocytesAngela S. Burke, Kelly R. Redeker, Richard C. Kurten, Laura Phillips James, Jack Hinson · 2007 · Journal of Toxicology and Environmental Health
- The effect of chloramphenicol on the biogenesis of mitochondria of rat liver in vivoA.M. Kroon, H. de Vries · 1969 · FEBS Letters
- Hepatitis during measles in young adults: Possible role of antipyretic drugsZvi Ackerman, Moshe Y. Flugelman, Yohanan Wax, Daniel Shouval, Micha Levy · 1989 · Hepatology
- Nonalcoholic fatty liver disease during valproate therapyAlberto Verrotti, Giovanna Di Marco, Rosanna la Torre, Piernicola Pelliccia, Francesco Chiarelli · 2009 · European Journal of Pediatrics
- Metabolic activation of the new tricyclic antidepressant tianeptine by human liver cytochrome P450Dominique G. Larrey, Marina Tinel, Philippe Lettéron, Patrick Maurel, Jacqueline Loeper, Jacques Belghiti, Dominique Pessayre · 1990 · Biochemical Pharmacology
- 2′,3′-Dideoxyinosine–Induced Mallory Bodies in Patients With HIVBing Ren Hu, Samuel William French · 1997 · American Journal of Clinical Pathology
- Flavin-Containing Monooxygenase-Mediated Metabolism of N-deacetylated Ketoconazole by Rat Hepatic MicrosomesRosita J. Rodriguez, Philip Proteau, Brian L. Márquez, Craig L. Hetherington, Cheryl J. Buckholz, Kerry L. O’Connell · 1999 · Drug Metabolism and Disposition
- Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosisAmy E. Chadwick, Sophie Regan, Charlotte M. Hirst, Emma E. Graham, Daniel James Antoine, Craig A. Benson, Dominic P. Williams, John Reginald Foster, J. Gerry Kenna, B. Kevin Park · 2009 · Toxicology and Applied Pharmacology
- Generation of T cell responses targeting the reactive metabolite of halothane in miceQiang You, Linling Cheng, Cynthia Ju · 2010 · Toxicology Letters
- Presence of covalently bound metabolites on rat hepatocyte plasma membrane proteins after administration of isaxonine, a drug leading to immunoallergic hepatitis in manJacqueline Loeper, Véronique Descatoire, Gilles Amouyal, Philippe Lettéron, Dominique G. Larrey, Dominique Pessayre · 1989 · Hepatology
- Covalent Binding of a Reactive Metabolite Derived from Propranolol and Its Active Metabolite 4-Hydroxypropranolol to Hepatic Microsomal Proteins of the RatShizuo Narimatsu, Takayuki Arai, Toshiyuki Watanabe, Yasuhiro Masubuchi, Toshiharu Horie, Tokuji Suzuki, Tsutomu Ishikawa, Michio Tsutsui, Yoshito Kumagai, Arthur K. Cho · 1997 · Chemical Research in Toxicology
- Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cellsMichel P deBaar, E DEROOIJ, Karlijn Smolders, H VANSCHIJNDEL, Eveline C. Timmermans, Richard C. Bethell · 2007 · Antiviral Research
- Effect of surgery under general anaesthesia on antipyrine clearance.Dominique Pessayre, Hubert Allemand, C Benoist, F Afifi, M Francois, JP Benhamou · 1978 · British Journal of Clinical Pharmacology
- In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation MechanismJian Yu, Dean G. Brown, Doug Burdette · 2010 · Drug Metabolism and Disposition
- Methotrexate: Studies on the cellular metabolism. I. Effect on mitochondrial oxygen uptake and oxidative phosphorylationNair Seiko Yamamoto, Ma. Benigna M. Oliveira, Annibal Paiva Campello, Luiz Carlos Vieira Lopes, M.L.W Kluppel · 1988 · Cell Biochemistry and Function
- Nuclear migration of NF-kappa B correlates with TNF-alpha mRNA accumulation.Hugo Albrecht, Lawrence B. Schook, C. Victor Jongeneel · 1995 · PubMed
- Evidence for a Medium-Chain Fatty Acid:Coenzyme A Ligase (Adenosine Monophosphate) That Activates SalicylatePaul G. Killenberg, Eugene D. Davidson, Leslie T. Webster · 1971 · Molecular Pharmacology
- Most cases of medium-chain acyl-CoA dehydrogenase deficiency escape detection in FranceBernard Fromenty, Abdellah Mansouri, Jean‐Paul Bonnefont, Françoise Courtois, Arnold Münnich, Daniel Rabier, Dominique Pessayre · 1996 · Human Genetics
- Dequalinium Induces a Selective Depletion of Mitochondrial DNA from HeLa Human Cervical Carcinoma CellsKristen R. Schneider Berlin, Chandramohan V. Ammini, Thomas C. Rowe · 1998 · Experimental Cell Research
- Identification of S-(n-Butylcarbamoyl)glutathione, a Reactive Carbamoylating Metabolite of Tolbutamide in the Rat, and Evaluation of Its Inhibitory Effects on Glutathione Reductase in VitroXiangming Guan, Margaret R. Davis, Cuyue Tang, Claudia M. Jochheim, Lixia Jin, Thomas A. Baillie · 1999 · Chemical Research in Toxicology
- Myeloperoxidase-mediated bioactivation of 5-hydroxythiabendazole: A possible mechanism of thiabendazole toxicityJoseph D. Jamieson, Evan B. Smith, Deepak Dalvie, Gregory J. Stevens, Gina M. Yanochko · 2011 · Toxicology in Vitro
- Neutrophil- and Myeloperoxidase-Mediated Metabolism of Reduced Nimesulide: Evidence for BioactivationMin Yang, Mahendra D. Chordia, Fengping Li, Tao Huang, Joel M Linden, Timothy L. Macdonald · 2010 · Chemical Research in Toxicology
- Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism.Gregory A. Reed, I O Griffin, Thomas E. Eling · 1985 · Molecular Pharmacology
- Nitroglycerine causes mitochondrial reactive oxygen species production: In vitro mechanistic insightsTommaso Gori, Andreas Daiber, Giuseppe Di Stolfo, Silvia Sicuro, Saverio Dragoni, Monica Lisi, Thomas F. Münzel, Sandro Forconi, John D. Parker · 2007 · Canadian Journal of Cardiology
- Acute inhibition of oxidative drug metabolism by propoxyphene (Darvon)George R. Peterson, Russell M. Hostetler, Thomas Lehman, H.Patrick Covault · 1979 · Biochemical Pharmacology
- Interferons Suppress Mitochondrial Gene Transcription by Depleting Mitochondrial Transcription Factor A (mtTFA)Hidetoshi Inagaki, Yuichi Matsushima, Mikiko Ohshima, Yasuo Kitagawa · 1997 · Journal of Interferon & Cytokine Research
- Suicide inactivation of cytochrome P-450 by methoxsalen. Evidence for the covalent binding of a reactive intermediate to the protein moiety.Gilles Labbe, Véronique Descatoire, Philippe H. Beaune, Philippe Lettéron, Dominique G. Larrey, Dominique Pessayre · 1989 · Journal of Pharmacology and Experimental Therapeutics
- Une méthode d'enregistrement continu de la radioactivité au cours de chromatographiesJean Berthet · 1954 · Biochimica et Biophysica Acta
- CYP17 polymorphism as a risk factor of tamoxifen-induced hepatic steatosis in breast cancer patientsTakenao Ohnishi, Yasuhiro Ogawa, Toshiji Saibara, Akihito Nishioka, Shinji Kariya, Mitsutaka Fukumoto, Saburo Onishi, Shoji Yōshida · 2005 · Oncology Reports
- Potentiation of the Toxic Effects of Acetaminophen in Mice by Concurrent Infection with Influenza B Virus: a Possible Mechanism for Human Reye's Syndrome?M G MacDonald, Philip P. McGrath, Donald N. McMartin, GEORGE C MARSHALL INST WASHINGTON, G Hudak · 1984 · Pediatric Research
- The role of cytochrome P-450-inducing agents in potentiating the toxicity of fluroxene (2,2,2-trifluoroethyl vinyl ether)Michael J. Murphy, Lawrence J. Piper, Donald N. McMartin, Laurence S. Kaminsky · 1980 · Toxicology and Applied Pharmacology
- Study of Mitochondrial DNA Deletion in AlcoholicsMutsumi Tsuchishima, Mikihiro Tsutsumi, Hisakazu Shiroeda, Hirokazu Yano, Yasuhiro Ueshima, Koshi Shimanaka, Shujiro Takase · 2000 · Alcoholism Clinical and Experimental Research
- Acetaminophen and Hepatic Dysfunction in Infectious MononucleosisDAVID M. ROSENBERG, Albert A. Meyer, ISAAC H. MANNING, Francis A. Neelon · 1977 · Southern Medical Journal
- The Antihypertensive Drug Carvedilol Inhibits the Activity of Mitochondrial NADH-Ubiquinone OxidoreductaseTiziana Cocco, Giuseppe Cutecchia, Grazia Montedoro, Michele Pio Lorusso · 2002 · Journal of Bioenergetics and Biomembranes
- Pharmacokinetics of amineptine in manC. Sbarra, Maria Grazia Castelli, Alessandro Noseda, Roberto Fanelli · 1981 · European Journal of Drug Metabolism and Pharmacokinetics
- Steroidal drug cyproterone acetate is activated to DNA-binding metabolites by sulfonation.S Werner, Susanne Kunz, Th. Wolff, L.R. Schwarz · 1996 · PubMed
- Human Anti-Mitochondria Autoantibodies Appearing in Iproniazid-Induced Immunoallergic Hepatitis Recognize Human Liver Monoamine Oxidase BCatherine Pons, Patrick M. Dansette, J Gregeois, Jean‐Claude Homberg, E. Ellen Billett, Daniel Mansuy · 1996 · Biochemical and Biophysical Research Communications
- Metabolic activation of unsaturated derivatives of valproic acid: role of microsomal versus mitochondrial enzyme systemsThomas A. Baillie, Kelem Kassahun, Mark P. Grillo, Pei Lin Hu, Michael A. Shirley, Jing Lin, R H Lévy · 1992 · Journal of Basic and Clinical Physiology and Pharmacology
- Mechanism for isaxonine hepatitis. I. Metabolic activation by mouse and human cytochrome P-450.Philippe Lettéron, H Fouin-Fortunet, Marina Tinel, Gaby Danan, Jacques Belghiti, Dominique Pessayre · 1984 · Journal of Pharmacology and Experimental Therapeutics
- Drug-induced increased mitochondrial biogenesis in a liver biopsyMohammad Amjad Kamal, Samuel William French · 2004 · Experimental and Molecular Pathology
- Carnitine administration ameliorates the changes in energy metabolism caused by short-term pivampicillin medicationBéla Melegh, Marianna Pap, Dénes Molnár, G Masszi, Gábor Kopcsányi · 1997 · European Journal of Pediatrics
- Interaction of dantrolene with the hepatic mixed function oxidase system.Roy S, Francis Ft, Born Ck, M E Hamrick · 1980 · PubMed
- Three RFLPs defining a haplotype associated with the common mutation in human medium-chain acyl-CoA dehydrogenase (MCAD) deficiency occur in Alu repeats.Z. Zhang, Steen Kølvraa, Y Zhou, Daniel P. Kelly, Nanna Vendelboe Gregersen, Arnold W. Strauss · 1993 · PubMed
- Use of adult human hepatocytes in primary culture for the study of clometacin-induced immunoallergic hepatitisLaurent Siproudhis, Michel Beaugrand, Yannick Mallédant, Pierre Brissot, Christiane Guguen‐Guillouzo, André Guillouzo · 1991 · Toxicology in Vitro
- Isozyme selective alterations of the expression of cytochrome P450 during regeneration of male rat liver following partial hepatectomyMayumi Ishizuka, S. YOSHINO, Yukio Yamamoto, Hideo Yamamoto, Susumu Imaoka, Yoshihiko Funae, Mio Masuda, Hisato Iwata, Akio Kazusaka, S. FUJITA* · 1997 · Xenobiotica
- Iproclozide fulminant hepatitisDominique Pessayre, Patrick De Saint-Louvent, Claude Degott, Jacques Bernuau, BERNARD RUEFF, Jean‐Pierre Benhamou · 1978 · Gastroenterology
- 794 Role of acetaminophen in acute liver failure due to viral hepatitisJulie Polson, Ponsiano Ocama, A LARSON, Linda Susan Hynan, E LALANI, M HARRISON, W LEE · 2003 · Hepatology
- Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formationMarie‐Anne Robin, Véronique Descatoire, Dominique Pessayre, Alain Berson · 2008 · Toxicology in Vitro
- Bioactivation of Glafenine by Human Liver Microsomes and Peroxidases: Identification of Electrophilic Iminoquinone Species and GSH ConjugatesBo Wen, David J. Moore · 2011 · Drug Metabolism and Disposition
- Genetically determined oxidation polymorphism and drug hepatotoxicityDominique G. Larrey, Marina Tinel, Gilles Amouyal, Eric Fréneaux, Alain Berson, H Fouin-Fortunet, G Babany, Philippe Lettéron, Franck Iglicki, Jean-Louis Slama et al. · 1989 · Journal of Hepatology
- A Murine Model of Acute Liver Injury Induced by Human Monoclonal Autoantibody *Katsumi Yamauchi, Naoko Yamaguchi, Takaji Furukawa, Kazuko Takatsu, Toshimi Nakanishi, Kohji Ishida, Tatsuji Komatsu, Katsutoshi Tokushige, Hikaru Nagahara, Etsuko Hashimoto et al. · 2005 · Hepatology
- Macrovesicular steatosis induced by interferon alfa therapy for chronic myelogenous leukaemiaLaurent Castéra, Е. Kalinsky, Pierre Bédossa, G. Tertian, C Buffet · 1999 · Liver International
- Selective alteration of mitochondrial function by ditercalinium (NSC 335153), a DNA bisintercalating agentCatherine Esnault, S. Brown, Evelyne Segal-Bendirdjian, Dominique Coulaud, Zohar Mishal, Bernard Pierre Roques, Jean Bernard Le Pecq · 1990 · Biochemical Pharmacology
- Drug-Induced Liver DiseaseNeil Kaplowitz · 2007 · CRC Press eBooks
- Ca2+influx initiates death of hepatocytes injured by activation of complementYoshiyuki Nishikawa, Minoru Ukida, Ryuichi Matsuo, Nobuhiko Omori, Takao Tsuji · 1994 · Liver International
- Effect of Selective Phase II Enzyme Inducers on Glucuronidation of Benoxaprofen in RatsJennifer Q. Dong, Amy S. Etheridge, Philip C. Smith · 1999 · Drug Metabolism and Disposition
- Phencyclidine metabolite irreversible binding in the rat: gonadal steroid regulation and CYP2C11.Susan R. Shelnutt, Thomas M. Badger, Samuel Michael Owens · 1996 · Journal of Pharmacology and Experimental Therapeutics