The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
α-Lipoic Acid: A Metabolic Antioxidant Which Regulates NF-κB Signal Transduction and Protects Against Oxidative Injury
Abstract
Although the metabolic role of alpha-lipoic acid has been known for over 40 years, it is only recently that its effects when supplied exogenously have become known. Exogenous alpha-lipoic acid is reduced intracellularly by at least two and possibly three enzymes, and through the actions of its reduced form, it influences a number of cell process. These include direct radical scavenging, recycling of other antioxidants, accelerating GSH synthesis, and modulating transcription factor activity, especially that of NF-kappa B (Fig. 12). These mechanisms may account for the sometimes dramatic effects of alpha-lipoic acid in oxidative stress conditions (e.g., brain ischemia-reperfusion), and point the way toward its therapeutic use.
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Cites
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.
Schreck, R., Meier, B., Männel, D. N., Dröge, W., & Baeuerle, P. A. (1992) · The Journal of experimental medicine · doi:10.1084/jem.175.5.1181 · Cited by 1,508
Alternative excitotoxic hypotheses
Albin, R. L., & Greenamyre, J. T. (1992) · Neurology · doi:10.1212/wnl.42.4.733 · Cited by 574
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Antioxidant Therapy in Acute Central Nervous System Injury: Current State
Gilgun-Sherki, Y., Rosenbaum, Z., Melamed, E., & Offen, D. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.271 · Cited by 568
Molecular aspects of lipoic acid in the prevention of diabetes complications
Packer, L., Kraemer, K., & Rimbach, G. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00658-x · Cited by 556
Self-citationLipoic acid – biological activity and therapeutic potential
Gorąca, A., Huk-Kolega, H., Piechota, A., Kleniewska, P., Ciejka, E., & Skibska, B. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70600-4 · Cited by 465
Lim, S.-Y., Hong, K.-H., Kim, D. I., Kwon, H., & Kim, H.-J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja500962u · Cited by 461
Metadata
- Authors
- Packer, L.
- Venue
- Drug Metabolism Reviews
- Publisher
- Informa UK Limited
- Published
- 1998-01
- Volume
- 30
- Issue
- 2
- Pages
- 245-275
- ISSN
- 0360-2532 (ISSN-L)
- 1097-9883
- OpenAlex
- W2000540842
- Cited by
- 207
- References
- 2
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: α-Lipoic Acid: A Metabolic Antioxidant Which Regulates NF-κB Signal Transduction and Protects Against Oxidative Injury. https://app.cochat.ai/papers/10.3109/03602539808996311
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- Packer, L. (1998). α-Lipoic Acid: A Metabolic Antioxidant Which Regulates NF-κB Signal Transduction and Protects Against Oxidative Injury. Drug Metabolism Reviews. https://doi.org/10.3109/03602539808996311
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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