The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Development of Biodegradable and Injectable Latices for Controlled Release of Potent Drugs
Abstract
A new dosage form designed to provide parenteral drug delivery over a prolonged period of time following a standard injection has been investigated using testosterone as the model drug. The drug carrier consists of a biodegradable, biocompatible polymer in which the drug is dispersed on a molecular level. The polymer itself is formulated as a pseudolatex with high solid content (40.0%). The formulation has a low viscosity (97 cps) which can be injected easily through a hypodermic needle. The histopathology study showed good tissue compatibility of the pseudolatices and in-vivo tests on rats confirmed a prolonged release of drug over a 14 day period. The stability of the biodegradable poly-d, l-lactic acid latex was found not to be significantly changed over 120 days of storage at room temperature (25°). A six month study showed a slight increase (10%) in the viscosity of the parenteral product when stored at room temperature. The increase was attributed to partial coalescence of the polymer particles which had an initial diameter of 0.45 μm.
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Miller, R. A., Brady, J. M., & Cutright, D. E. (1977) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820110507 · Cited by 722
Long-acting delivery systems for narcotic antagonists. 1
Woodland, J. H. R., Yolles, S., Blake, D. A., Helrich, M., & Meyer, F. J. (1973) · Journal of Medicinal Chemistry · doi:10.1021/jm00266a007 · Cited by 95
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des Rieux, A., Fievez, V., Garinot, M., Schneider, Y.-J., & Préat, V. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.08.013 · Cited by 1,305
Nicolas, J., Mura, S., Brambilla, D., Mackiewicz, N., & Couvreur, P. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35265f · Cited by 1,270
A Novel Approach to the Oral Delivery of Micro- or Nanoparticles
Bodmeier, R., Chen, H., & Paeratakul, O. (1989) · Pharmaceutical Research · doi:10.1023/a:1015987516796 · Cited by 276
Leroux, J.-C., Allémann, E., De Jaeghere, F., Doelker, E., & Gurny, R. (1996) · Journal of Controlled Release · doi:10.1016/0168-3659(95)00164-6 · Cited by 268
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Metadata
- Authors
- Gurny, R., Peppas, N. A., Harrington, D. D., & Banker, G. S.
- Venue
- Drug Development and Industrial Pharmacy
- Publisher
- Informa UK Limited
- Published
- 1981-01
- Volume
- 7
- Issue
- 1
- Pages
- 1-25
- ISSN
- 0363-9045 (ISSN-L)
- 1520-5762
- OpenAlex
- W2090168663
- Cited by
- 197
- References
- 2
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gurny, R., Peppas, N. A., Harrington, D. D., & Banker, G. S. (1981). Development of Biodegradable and Injectable Latices for Controlled Release of Potent Drugs. Drug Development and Industrial Pharmacy. https://doi.org/10.3109/03639048109055684
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
