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Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer
Abstract
Spontaneous tumors in companion animals (dog and cat) offer a unique opportunity as models for human cancer biology and translational cancer therapeutics. The relatively high incidence of some cancers, similar biologic behavior, large body size, comparable responses to cytotoxic agents, and shorter overall lifespan are the factors that contribute to the advantages of the companion animal model. The tumor types that offer the best comparative interest include lymphoma/leukemia, osteosarcoma, STS, melanoma, and mammary tumors. With the increase in new therapeutic agents (traditional chemotherapy, gene therapy, biologic agents, etc.), the companion animal model can provide useful populations to test new agents where efficacy and toxicity can be examined.
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Cited by
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The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis
Khanna, C., Wan, X., Bose, S., Cassaday, R., Olomu, O., Mendoza, A., Yeung, C., Gorlick, R., Hewitt, S. M., & Helman, L. J. (2004) · Nature Medicine · doi:10.1038/nm982 · Cited by 705
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Paoloni, M., & Khanna, C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2273 · Cited by 668
Cancer Incidence in Pet Dogs: Findings of the Animal Tumor Registry of Genoa, Italy
Merlo, D. F., Rossi, L., Pellegrino, C., Ceppi, M., Cardellino, U., Capurro, C., Ratto, A., Sambucco, P. L., Sestito, V., Tanara, G., et al. (2008) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2008.0133.x · Cited by 403
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Roberts, N. J., Zhang, L., Janku, F., Collins, A., Bai, R.-Y., Staedtke, V., Rusk, A. W., Tung, D., Miller, M., Roix, J., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008982 · Cited by 400
Metadata
- Authors
- Vail, D. M., & Macewen, E. G.
- Venue
- Cancer Investigation
- Publisher
- Informa UK Limited
- Published
- 2000-01
- Volume
- 18
- Issue
- 8
- Pages
- 781-792
- ISSN
- 0735-7907 (ISSN-L)
- 1532-4192
- OpenAlex
- W2108627173
- Cited by
- 528
- References
- 0
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer. https://app.cochat.ai/papers/10.3109/07357900009012210
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- Vail, D. M., & Macewen, E. G. (2000). Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer. Cancer Investigation. https://doi.org/10.3109/07357900009012210
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
