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Upregulation of p53 Expression in Patients with Colorectal Cancer by Administration of Curcumin
Abstract
Biological therapies can be beneficial in cancer patients. The present study aims to examine the inhibitory mechanism of curcumin on cancer cells in patients with colorectal cancer. The results showed that curcumin administration increased body weight, decreased serum TNF-alpha levels, increased apoptotic tumor cells, enhanced expression of p53 molecule in tumor tissue, and modulated tumor cell apoptotic pathway. We conclude that the curcumin treatment improves the general health of patients with colorectal cancer via the mechanism of increased p53 molecule expression in tumor cells and consequently speeds up tumor cell apoptosis.
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Cited by
Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials
Gupta, S. C., Patchva, S., & Aggarwal, B. B. (2013) · The AAPS Journal · doi:10.1208/s12248-012-9432-8 · Cited by 2,110
Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects
Kotha, R. R., & Luthria, D. L. (2019) · Molecules · doi:10.3390/molecules24162930 · Cited by 890
Natural Polyphenols for Prevention and Treatment of Cancer
Zhou, Y., Zheng, J., Li, Y., Xu, D.-P., Li, S., Chen, Y.-M., & Li, H.-B. (2016) · Nutrients · doi:10.3390/nu8080515 · Cited by 746
Pulido-Moran, M., Moreno-Fernandez, J., Ramirez-Tortosa, C., & Ramirez-Tortosa, M. (2016) · Molecules · doi:10.3390/molecules21030264 · Cited by 543
Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers
Aggarwal, B. B., Gupta, S. C., & Sung, B. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12131 · Cited by 395
Metadata
- Authors
- He, Z.-Y., Shi, C.-B., Wen, H., Li, F.-L., Wang, B.-L., & Wang, J.
- Venue
- Cancer Investigation
- Publisher
- Informa UK Limited
- Published
- 2011-02-11
- Volume
- 29
- Issue
- 3
- Pages
- 208-213
- ISSN
- 0735-7907 (ISSN-L)
- 1532-4192
- OpenAlex
- W2163815667
- Cited by
- 274
- References
- 0
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- He, Z.-Y., Shi, C.-B., Wen, H., Li, F.-L., Wang, B.-L., & Wang, J. (2011). Upregulation of p53 Expression in Patients with Colorectal Cancer by Administration of Curcumin. Cancer Investigation. https://doi.org/10.3109/07357907.2010.550592
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
