The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects
Open accessAbstract
Turmeric is a curry spice that originated from India, which has attracted great interest in recent decades because it contains bioactive curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin). Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione), a lipophilic polyphenol may work as an anticancer, antibiotic, anti-inflammatory, and anti-aging agent as suggested by several in vitro, in vivo studies and clinical trials. However, poor aqueous solubility, bioavailability, and pharmacokinetic profiles limit curcumin’s therapeutic usage. To address these issues, several curcumin formulations have been developed. However, suboptimal sample preparation and analysis methodologies often hamper the accurate evaluation of bioactivities and their clinical efficacy. This review summarizes recent research on biological, pharmaceutical, and analytical aspects of the curcumin. Various formulation techniques and corresponding clinical trials and in vivo outcomes are discussed. A detailed comparison of different sample preparation (ultrasonic, pressurized liquid extraction, microwave, reflux) and analytical (FT-IR, FT-NIR, FT-Raman, UV, NMR, HPTLC, HPLC, and LC-MS/MS) methodologies used for the extraction and quantification of curcuminoids in different matrices, is presented. Application of optimal sample preparation, chromatographic separation, and detection methodologies will significantly improve the assessment of different formulations and biological activities of curcuminoids.
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Cites
Bioavailability of curcumin: Problems and promises
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“Reduction of CUR primarily occurs through the heptadienone chain double bonds to form di-, tetra-, and octahydrocurcumin, which is facilitated by several enzymes such as NADPH-dependent reductase, alcohol dehydrogenase and an unidentified microsomal enzyme [18,22,50].”
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Dose escalation of a curcuminoid formulation
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Cited by
A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges
Puri, V., Nagpal, M., Singh, I., Singh, M., Dhingra, G. A., Huanbutta, K., Dheer, D., Sharma, A., & Sangnim, T. (2022) · Nutrients · doi:10.3390/nu14214637 · Cited by 348
Targeting Oxidative Stress Involved in Endometriosis and Its Pain
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“Various formulations of curcumin have been produced to address the issues of its pharmacokinetics, poor bioavailability, and low solubility when taken orally [142,147].”
BackgroundPolyphenols and neuroprotection: therapeutic implications for cognitive decline
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Zeng, L., Yu, G., Hao, W., Yang, K., & Chen, H. (2021) · Bioscience Reports · doi:10.1042/bsr20210817 · Cited by 120
Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs
Philips, C. A., Ahamed, R., Rajesh, S., George, T., Mohanan, M., & Augustine, P. (2020) · World Journal of Hepatology · doi:10.4254/wjh.v12.i9.574 · Cited by 57
Metadata
- Authors
- Kotha, R. R., & Luthria, D. L.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2019-08-13
- Volume
- 24
- Issue
- 16
- Pages
- 2930
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2968213237
- Cited by
- 890
- References
- 129
- FWCI
- 20.31
- Type
- journal article
- Language
- en
- Open access
- gold
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