Cited by 155Studies on Chitinases and ChitosanasesEnzyme Production and CharacterizationEnzyme Catalysis and Immobilization

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Chitinases: in agriculture and human healthcare

Nagpure, Anand, Choudhary, Bharti, Gupta, Rajinder K.·2014·Critical Reviews in Biotechnology

DOI 10.3109/07388551.2013.790874

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Abstract

Biological control of phytopathogenic fungi and insects continues to inspire the research and development of environmentally friendly bioactive alternatives. Potentially lytic enzymes, chitinases can act as a biocontrol agent against agriculturally important fungi and insects. The cell wall in fungi and protective covers, i.e. cuticle in insects shares a key structural polymer, chitin, a β-1,4-linked N-acetylglucosamine polymer. Therefore, it is advantageous to develop a common biocontrol agent against both of these groups. As chitin is absent in plants and mammals, targeting its metabolism will signify an eco-friendly strategy for the control of agriculturally important fungi and insects but is innocuous to mammals, plants, beneficial insects and other organisms. In addition, development of chitinase transgenic plant varieties probably holds the most promising method for augmenting agricultural crop protection and productivity, when properly integrated into traditional systems. Recently, human proteins with chitinase activity and chitinase-like proteins were identified and established as biomarkers for human diseases. This review covers the recent advances of chitinases as a biocontrol agent and its various applications including preparation of medically important chitooligosaccharides, bioconversion of chitin as well as in implementing chitinases as diagnostic and prognostic markers for numerous diseases and the prospect of their future utilization.

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Authors: Nagpure, A., Choudhary, B., & Gupta, R. K.
Affiliations: Guru Gobind Singh Indraprastha University (IN)
Corresponding author: Gupta, Rajinder K.
ORCID: Gupta, Rajinder K.
Venue: Critical Reviews in Biotechnology
Publisher: Informa UK Limited
Published: 2013-07-16
Volume: 34
Issue: 3
Pages: 215-232
ISSN: 0738-8551 (ISSN-L)
1549-7801
DOI: 10.3109/07388551.2013.790874
OpenAlex: W2007954503
Cited by: 145
References: 281
Citations by year: 2026: 5 · 2025: 16 · 2024: 6 · 2023: 18 · 2022: 14 · 2021: 20 · 2020: 14 · 2019: 12 · 2018: 9 · 2017: 12 · 2016: 9 · 2015: 7 · 2014: 1 · 2013: 2
FWCI: 0.60
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Biotechnology (publishedVersion)
PubMed (publishedVersion)
Funders: Universidad de Guanajuato
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Studies on Chitinases and Chitosanases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme Catalysis and Immobilization
Keywords: chitinase, biological control, plant pathogenic fungi, insect pests, chitin, chitooligosaccharides, transgenic plants, crop protection, disease biomarkers, fungal cell wall, insect cuticle
MeSH terms: Agriculture, Animals, Antifungal Agents, Antiprotozoal Agents, Chitinases, Delivery of Health Care, Humans, Pest Control, Biological

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Chitinases: in agriculture and human healthcare

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