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Chitinases: in agriculture and human healthcare
Abstract
Biological control of phytopathogenic fungi and insects continues to inspire the research and development of environmentally friendly bioactive alternatives. Potentially lytic enzymes, chitinases can act as a biocontrol agent against agriculturally important fungi and insects. The cell wall in fungi and protective covers, i.e. cuticle in insects shares a key structural polymer, chitin, a β-1,4-linked N-acetylglucosamine polymer. Therefore, it is advantageous to develop a common biocontrol agent against both of these groups. As chitin is absent in plants and mammals, targeting its metabolism will signify an eco-friendly strategy for the control of agriculturally important fungi and insects but is innocuous to mammals, plants, beneficial insects and other organisms. In addition, development of chitinase transgenic plant varieties probably holds the most promising method for augmenting agricultural crop protection and productivity, when properly integrated into traditional systems. Recently, human proteins with chitinase activity and chitinase-like proteins were identified and established as biomarkers for human diseases. This review covers the recent advances of chitinases as a biocontrol agent and its various applications including preparation of medically important chitooligosaccharides, bioconversion of chitin as well as in implementing chitinases as diagnostic and prognostic markers for numerous diseases and the prospect of their future utilization.
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“However, chitinases from other sources than yeasts (i.e., filamentous fungi and bacteria) have demonstrated biocontrol activity against plant pathogenic fungi and chitinases are widely studied as potential biopesticides, targets for resistance breeding, or as transgenes in genetically modified plants (Dahiya et al. 2006; Herrera-Estrella and Chet 1999; Nagpure et al. 2014).”
From Biocontrol yeasts: mechanisms and applications (2019) · cites this paper as Nagpure et al. 2014
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Metadata
- Authors
- Nagpure, A., Choudhary, B., & Gupta, R. K.
- Affiliations
- Guru Gobind Singh Indraprastha University (IN)
- Corresponding author
- Gupta, Rajinder K.
- ORCID
- Gupta, Rajinder K.
- Venue
- Critical Reviews in Biotechnology
- Publisher
- Informa UK Limited
- Published
- 2013-07-16
- Volume
- 34
- Issue
- 3
- Pages
- 215-232
- ISSN
- 0738-8551 (ISSN-L)
- 1549-7801
- OpenAlex
- W2007954503
- Cited by
- 145
- References
- 281
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 6 · 2023: 18 · 2022: 14 · 2021: 20 · 2020: 14 · 2019: 12 · 2018: 9 · 2017: 12 · 2016: 9 · 2015: 7 · 2014: 1 · 2013: 2
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universidad de Guanajuato
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Studies on Chitinases and Chitosanases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme Catalysis and Immobilization
- Keywords
- chitinase, biological control, plant pathogenic fungi, insect pests, chitin, chitooligosaccharides, transgenic plants, crop protection, disease biomarkers, fungal cell wall, insect cuticle
- MeSH terms
- Agriculture, Animals, Antifungal Agents, Antiprotozoal Agents, Chitinases, Delivery of Health Care, Humans, Pest Control, Biological
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