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Yeast killer toxins, molecular mechanisms of their action and their applications
Abstract
Killer toxins secreted by some yeast strains are the proteins that kill sensitive cells of the same or related yeast genera. In recent years, many new yeast species have been found to be able to produce killer toxins against the pathogenic yeasts, especially Candida albicans. Some of the killer toxins have been purified and characterized, and the genes encoding the killer toxins have been cloned and characterized. Many new targets including different components of cell wall, plasma membrane, tRNA, DNA and others in the sensitive cells for the killer toxin action have been identified so that the new molecular mechanisms of action have been elucidated. However, it is still unknown how some of the newly discovered killer toxins kill the sensitive cells. Studies on the killer phenomenon in yeasts have provided valuable insights into a number of fundamental aspects of eukaryotic cell biology and interactions of different eukaryotic cells. Elucidation of the molecular mechanisms of their action will be helpful to develop the strategies to fight more and more harmful yeasts.
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“However, several of these toxins also inhibit or kill plant pathogenic fungi and were thus proposed for plant protection (Corbaci and Ucar 2018; Liu et al. 2015; Marquina et al. 2002; Perez et al. 2016).”
From Biocontrol yeasts: mechanisms and applications (2019) · cites this paper as Liu et al. 2015
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Metadata
- Authors
- Liu, G.-L., Chi, Z., Wang, G.-Y., Wang, Z.-P., Li, Y., & Chi, Z.-M.
- Affiliations
- Ocean University of China (CN)
- Corresponding author
- Wang, Zhi-Peng
- Chi, Zhen-Ming
- Venue
- Critical Reviews in Biotechnology
- Publisher
- Informa UK Limited
- Published
- 2013-10-09
- Volume
- 35
- Issue
- 2
- Pages
- 222-234
- ISSN
- 0738-8551 (ISSN-L)
- 1549-7801
- OpenAlex
- W2098553908
- Cited by
- 111
- References
- 73
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 14 · 2023: 13 · 2022: 9 · 2021: 8 · 2020: 19 · 2019: 13 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 2 · 2014: 2
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Life Sciences › Immunology and Microbiology › Immunology › Toxin Mechanisms and Immunotoxins
- Keywords
- yeast killer toxin, Candida albicans, pathogenic yeasts, cell wall, plasma membrane, tRNA, DNA, toxin gene cloning
- MeSH terms
- Biotechnology, Candida, Killer Factors, Yeast
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