Killer toxin from a novel killer yeast Pichia kudriavzevii RY55 with idiosyncratic antibacterial activity
Abstract
The killer phenomenon of yeast may have technological implications in many areas like beverage fermentation, food technology, biological control in agriculture, and in medicine. In the present study the killer phenomenon in Pichia kudriavzevii (P. kudriavzevii RY55) is being reported for the first time. The P. kudriavzevii RY55 toxin exhibited excellent antibacterial activity against several pathogens of human health significance such as Escherichia coli, Enterococcus faecalis, Klebsiella sp., Staphylococcus aureus, Pseudomonas aeruginosa and Pseudomonas alcaligenes. Killer toxin was purified to homogeneity by using ammonium sulphate precipitation and ion exchange chromatography and characterized for few properties. P. kudriavzevii RY55 killer toxin may be of vast significance in the development of novel antimicrobial chemotherapeutic agents, new bio-based safer candidates for food preservation and biocontrol, and starter cultures for fermentation industries.
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The most prominent toxins produced by many biocontrol yeast strains are proteinaceous killer toxins.
“The most prominent toxins produced by many biocontrol yeast strains are proteinaceous killer toxins (Supplementary Table 1)”
From Biocontrol yeasts: mechanisms and applications (2019) · cites this paper as Bajaj et al. 2013
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FERMENTAÇÃO SEMI-CARBÔNICA DE CAFÉ (COFFEA ARABICA) EM SILOS
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- Authors
- Bajaj, B. K., Raina, S., & Singh, S.
- Affiliations
- University of Jammu (IN)
- Corresponding author
- Bajaj, Bijender Kumar
- Venue
- Journal of Basic Microbiology
- Publisher
- Wiley
- Published
- 2012-09-07
- Volume
- 53
- Issue
- 8
- Pages
- 645-656
- ISSN
- 0233-111X (ISSN-L)
- OpenAlex
- W1897393515
- Cited by
- 83
- References
- 37
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 8 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Basic Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Grants Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Keywords
- killer toxin, killer yeast, Candida krusei, antibacterial activity, toxin purification, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Pseudomonas alcaligenes, food preservation, biological control, starter cultures, antimicrobial agents
- MeSH terms
- Anti-Bacterial Agents, Antifungal Agents, Chromatography, Ion Exchange, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Fermentation, Hydrogen-Ion Concentration, Klebsiella, Microbial Sensitivity Tests, Mycotoxins, Pichia, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Temperature, Time Factors, Pseudomonas alcaligenes
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