Vasopressin: A potent autocrine/paracrine regulator of mammal adrenal functions.
Abstract
The control of adrenal functions by locally secreted neuropeptides or neurotransmitters is of great physiological importance. Vasopressin (VP) is one of these autocrine/paracrine regulators. We demonstrated by RT-PCR and perifusion experiments that rat and human adrenal medulla expressed and released vasopressin under basal conditions and under stimulation by acetylcholine. Intra-adrenal concentrations of VP may be sufficient to activate adrenal VP receptors. In the cortex, only the V1a receptor subtype has been detected. It triggered both steroid secretion and cortical growth. In the medulla, both V1a and V1b receptor subtypes were expressed. V1b receptors were mainly present on chromaffin cells and stimulated catecholamine secretion. The role of the V1a receptor remains unclear. Pathophysiological studies also revealed that human pheochromocytoma did not overexpress vasopressin receptors but might oversecrete vasopressin causing high plasma VP concentrations and elevated blood pressure.
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VP may raise glucagon release either by activating V1b receptors in pancreatic islets or indirectly by promoting adrenaline secretion from the adrenal medulla.
“Glucagon secretion could be increased by VP through activation of V1bR in pancreatic islets [7][8][9], or indirectly by stimulating adrenaline (epinephrine) secretion by chromaffin cells of the adrenal medulla [36].”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [36]
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- Authors
- Guillon, G., Grazzini, E., Andrez, M., Breton, C., Trueba, M., Gal, C. S.-L., Boccara, G., Derick, S., Chouinard, L., & Gallo-payet, N.
- Affiliations
- Inserm (FR)
- Sanofi (France) (FR)
- Université de Sherbrooke (CA)
- Venue
- Endocrine Research
- Publisher
- Informa UK Limited
- Published
- 1998-01
- Volume
- 24
- Issue
- 3-4
- Pages
- 703-710
- ISSN
- 0743-5800 (ISSN-L)
- 1532-4206
- OpenAlex
- W2110422583
- Cited by
- 55
- References
- 11
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- vasopressin, autocrine and paracrine regulation, adrenal medulla, adrenal cortex, V1a receptor, V1b receptor, acetylcholine, chromaffin cells, catecholamine release, steroid secretion, adrenal growth, pheochromocytoma, hypertension, neuropeptides
- MeSH terms
- Adrenal Glands, Adrenal Medulla, Animals, Humans, Vasopressins, Receptors, Vasopressin, Autocrine Communication, Paracrine Communication, Rats
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