The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Ophthalmic features of systemic diseases
Open accessAbstract
The eye is intricately integrated with the functions of the body. Ocular changes may precede or run concurrently with various systemic conditions and often represent important prognostic indicators of disease progression. In addition to a thorough diagnostic evaluation and treatment of underlying processes, individuals with systemic diseases and concurrent ocular changes may need comprehensive ophthalmic examination to reduce the risk of visual impairment and morbidity. In this review the authors highlight the clinically relevant ocular signs that occur parallel with systemic conditions. In particular, the study focuses on the varied clinical presentations that can lead to rapid diagnosis to improve management of eye disorders that accompany systemic diseases.
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“Moreover, many ophthalmic conditions, such as diabetic retinopathy, thyroid-associated ophthalmopathy, and steroid-induced cataracts, are related to systemic diseases55”
From A large language model digital patient system enhances ophthalmology history taking skills (2025) · cites this paper as [55]
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The impact of ocular blood flow in glaucoma
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Idiopathic Intracranial Hypertension
Wall, M. (2010) · Neurologic Clinics · doi:10.1016/j.ncl.2010.03.003 · Cited by 656
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Cerebral White Matter Lesions, Retinopathy, and Incident Clinical Stroke
Wong, T. Y. (2002) · JAMA · doi:10.1001/jama.288.1.67 · Cited by 486
Retinal microvascular abnormalities and 10-year cardiovascular mortality
Wong, T. Y., Klein, R., Nieto, F. J., Klein, B. E. K., Sharrett, A. R., Meuer, S. M., Hubbard, L. D., & Tielsch, J. M. (2003) · Ophthalmology · doi:10.1016/s0161-6420(03)00084-8 · Cited by 349
Mazlumzadeh, M., Hunder, G. G., Easley, K. A., CALAMIA, K. T., Matteson, E. L., Griffing, W. L., Younge, B. R., Weyand, C. M., & Goronzy, J. J. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22163 · Cited by 345
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Retinal Microvascular Abnormalities and Renal Dysfunction
Wong, T. Y., Coresh, J., Klein, R., Muntner, P., Couper, D. J., Sharrett, A. R., Klein, B. E. K., HEISS, G. M., Hubbard, L. D., & Duncan, B. B. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000136133.28194.e4 · Cited by 233
African Descent and Glaucoma Evaluation Study (ADAGES)
Skaat, A., Moraes, C. G. D., Bowd, C., Sample, P. A., Girkin, C. A., Medeiros, F. A., Ritch, R. H., Weinreb, R. N., Zangwill, L. M., & Liebmann, J. M. (2016) · Ophthalmology · doi:10.1016/j.ophtha.2016.03.025 · Cited by 221
Research works printed but not linked: 1
- 10.1016/S0039-6257(04)00110-9 · DOI
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Sorted by citations
A large language model digital patient system enhances ophthalmology history taking skills
Luo, M.-J., Bi, S., Pang, J., Liu, L., Tsui, C.-K., Lai, Y., Chen, W., Yang, Y., Xu, K., Zhao, L., et al. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-01841-6 · Cited by 39
“Moreover,manyophthalmicconditions,suchas diabeticretinopathy,thyroid-associatedophthalmopathy,andsteroid-inducedcataracts,arerelatedtosystemicdiseases 55 , enhancing students ’ understanding of the interconnectedness of different body systems.”
Li, J., Gao, Z., Ning, L., Yao, L., Liu, C., Xu, C., Ren, X., Wang, A., Gao, S., Wang, M., et al. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s464524 · Cited by 5
Ophthalmic clues to the endocrine disorders
Liu, Z., Chen, Y., Lin, Z., & Shi, X. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0532-7 · Cited by 2
Eye as the First Manifestation Place of Various Systemical Diseases
Turgut, B. (2017) · Advances in Ophthalmology & Visual System · doi:10.15406/aovs.2017.07.00230
Validación de modelo de fantoma en simulación de fondo de ojo para alumnos de pregrado
Vargas-Sepúlveda, C., Salgado, L., Musa, P., Varas, J., & Grau, A. E. (2024) · Revista Latinoamericana de Simulación Clínica · doi:10.35366/115802
Oculomics Opportunities and Challenges for Optometry
Sauvageau, P. (2025) · Canadian journal of optometry/CJO. Canadian journal of optometry · doi:10.15353/cjo.v87i2.6283
Metadata
- Authors
- Hazin, R., Lum, F., & Daoud, Y. J.
- Affiliations
- Massachusetts Eye and Ear Infirmary (US)
- American Academy of Ophthalmology (US)
- Johns Hopkins University (US)
- Corresponding author
- Daoud, Yassine J.
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2011-05-13
- Volume
- 44
- Issue
- 3
- Pages
- 242-252
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2118348276
- Cited by
- 6
- References
- 48
- Citations by year
- 2025: 2 · 2024: 2 · 2017: 1 · 2016: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal and Optic Conditions
- Health Sciences › Medicine › Ophthalmology › Ophthalmology and Visual Health Research
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- ocular manifestations of systemic disease, ocular manifestations, visual impairment
- MeSH terms
- Cardiovascular Diseases, Endocrine System Diseases, Eye, Eye Diseases, Humans, Lung Diseases, Disease Progression, Early Diagnosis
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