The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Ophthalmic features of systemic diseases
Open accessAbstract
The eye is intricately integrated with the functions of the body. Ocular changes may precede or run concurrently with various systemic conditions and often represent important prognostic indicators of disease progression. In addition to a thorough diagnostic evaluation and treatment of underlying processes, individuals with systemic diseases and concurrent ocular changes may need comprehensive ophthalmic examination to reduce the risk of visual impairment and morbidity. In this review the authors highlight the clinically relevant ocular signs that occur parallel with systemic conditions. In particular, the study focuses on the varied clinical presentations that can lead to rapid diagnosis to improve management of eye disorders that accompany systemic diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, many ophthalmic conditions, such as diabetic retinopathy, thyroid-associated ophthalmopathy, and steroid-induced cataracts, are related to systemic diseases55”
From A large language model digital patient system enhances ophthalmology history taking skills (2025) · cites this paper as [55]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Stratton, I. M. (2000) · BMJ · doi:10.1136/bmj.321.7258.405 · Cited by 9,059
The impact of ocular blood flow in glaucoma
Flammer, J., Orgül, S., Costa, V. P., Orzalesi, N., Krieglstein, G. K., Serra, L. M., Renard, J. P., & Stefánsson, E. (2002) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(02)00008-3 · Cited by 1,714
Idiopathic Intracranial Hypertension
Wall, M. (2010) · Neurologic Clinics · doi:10.1016/j.ncl.2010.03.003 · Cited by 656
Wong, T. Y., & Mitchell, P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60198-6 · Cited by 602
Cerebral White Matter Lesions, Retinopathy, and Incident Clinical Stroke
Wong, T. Y. (2002) · JAMA · doi:10.1001/jama.288.1.67 · Cited by 486
Retinal microvascular abnormalities and 10-year cardiovascular mortality
Wong, T. Y., Klein, R., Nieto, F. J., Klein, B. E. K., Sharrett, A. R., Meuer, S. M., Hubbard, L. D., & Tielsch, J. M. (2003) · Ophthalmology · doi:10.1016/s0161-6420(03)00084-8 · Cited by 349
Mazlumzadeh, M., Hunder, G. G., Easley, K. A., CALAMIA, K. T., Matteson, E. L., Griffing, W. L., Younge, B. R., Weyand, C. M., & Goronzy, J. J. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22163 · Cited by 345
Younis, N., Broadbent, D., Vora, J. P., & Harding, S. P. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12267-2 · Cited by 287
Retinal Microvascular Abnormalities and Renal Dysfunction
Wong, T. Y., Coresh, J., Klein, R., Muntner, P., Couper, D. J., Sharrett, A. R., Klein, B. E. K., HEISS, G. M., Hubbard, L. D., & Duncan, B. B. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000136133.28194.e4 · Cited by 233
African Descent and Glaucoma Evaluation Study (ADAGES)
Skaat, A., Moraes, C. G. D., Bowd, C., Sample, P. A., Girkin, C. A., Medeiros, F. A., Ritch, R. H., Weinreb, R. N., Zangwill, L. M., & Liebmann, J. M. (2016) · Ophthalmology · doi:10.1016/j.ophtha.2016.03.025 · Cited by 221
Retinal microvascular signs and risk of stroke and stroke mortality
Mitchell, P., Wang, J. J., Wong, T. Y., Smith, W. T., Klein, R., & Leeder, S. (2005) · Neurology · doi:10.1212/01.wnl.0000179177.15900.ca · Cited by 215
Retinal Microvascular Abnormalities and Risk of Lacunar Stroke
Yatsuya, H., Folsom, A. R., Wong, T. Y., Klein, R., Klein, B. E. K., & Sharrett, A. R. (2010) · Stroke · doi:10.1161/strokeaha.110.580837 · Cited by 201
Floppy Eyelid Syndrome and Obstructive Sleep Apnea
McNab, A. A. (1997) · Ophthalmic Plastic and Reconstructive Surgery · doi:10.1097/00002341-199706000-00005 · Cited by 201
Retinal vein occlusion: pathophysiology and treatment options
Karia, N. (2010) · Clinical ophthalmology · doi:10.2147/opth.s7631 · Cited by 184
Treatment of Nonarteritic Anterior Ischemic Optic Neuropathy
Atkins, E. J., Bruce, B. B., Newman, N. J., & Biousse, V. (2009) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2009.06.008 · Cited by 179
Autoregulation, a balancing act between supply and demand
Flammer, J., & Mozaffarieh, M. (2008) · Canadian Journal of Ophthalmology · doi:10.3129/i08-056 · Cited by 175
Prevalence of Normal Tension Glaucoma in Obstructive Sleep Apnea Syndrome Patients
Sergi, M., Salerno, D. E., Rizzi, M., Blini, M., Andreoli, A., Messenio, D., Pecis, M., & Bertoni, G. (2007) · Journal of Glaucoma · doi:10.1097/01.ijg.0000243472.51461.24 · Cited by 165
Cheung, N., Mosley, T. H., Islam, A. F. M., Kawasaki, R., Sharrett, A. R., Klein, R., Coker, L. H., Knopman, D. S., Shibata, D. K., Catellier, D., et al. (2010) · Brain · doi:10.1093/brain/awq127 · Cited by 151
Autonomic nervous system, circadian rhythms, and primary open-angle glaucoma
Gherghel, D., Hosking, S. L., & Orgül, S. (2004) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2004.06.003 · Cited by 101
The Associations of Floppy Eyelid Syndrome: A Case Control Study
Ezra, D. G., Beaconsfield, M., Sira, M., Bunce, C., Wormald, R., & Collin, R. (2010) · Ophthalmology · doi:10.1016/j.ophtha.2009.09.029 · Cited by 100
Retinal emboli and cardiovascular disease: the Beaver Dam Eye Study.
Klein, R., Klein, B. E. K., Moss, S. E., & Meuer, S. M. (2003) · PubMed Central · doi:10.1001/archopht.121.10.1446 · Cited by 100
Ipsilateral recurrence of nonarteritic anterior ischemic optic neuropathy
Hayreh, S. S., Podhajsky, P. A., & Zimmerman, B. M. (2001) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)01192-8 · Cited by 95
African Descent and Glaucoma Evaluation Study (ADAGES)
Racette, L. (2010) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2010.58 · Cited by 94
Prevalence of Floppy Eyelid Syndrome in Obstructive Sleep Apnea–Hypopnea Syndrome
Karger, R. A., WHITE, W., PARK, W., ROSALES, A., MCLAREN, J., OLSON, E., & Woog, J. J. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2006.02.053 · Cited by 92
Lifestyle, Nutrition, and Glaucoma
Pasquale, L. R., & Kang, J. H. (2009) · Journal of Glaucoma · doi:10.1097/ijg.0b013e31818d3899 · Cited by 89
Risk factors for idiopathic intracranial hypertension in men: A case–control study
Fraser, J. A., Bruce, B. B., Rucker, J. C., Fraser, L.-A., Atkins, E. J., Newman, N. J., & Biousse, V. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.11.001 · Cited by 79
Retinal Arteriolar Emboli and Long-Term Mortality
Wang, J. J., Cugati, S., Knudtson, M. D., Rochtchina, E., Klein, R., Klein, R., Wong, T. Y., & Mitchell, P. (2006) · Stroke · doi:10.1161/01.str.0000226929.23297.75 · Cited by 79
Behbehani, R. S., Mathews, M. K., Sergott, R. C., & Savino, P. J. (2005) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2004.11.004 · Cited by 71
Prevalence of Asymptomatic Retinal Emboli in an Australian Urban Community
Mitchell, P., Wang, J. J., Li, W., Leeder, S., & Smith, W. T. (1997) · Stroke · doi:10.1161/01.str.28.1.63 · Cited by 70
Retinal Microvascular Signs and 10-Year Risk of Cerebral Atrophy
Kawasaki, R., Cheung, N., Mosley, T. H., Islam, A. F. M., Sharrett, A. R., Klein, R., Coker, L. H., Knopman, D. S., Shibata, D. K., Catellier, D., et al. (2010) · Stroke · doi:10.1161/strokeaha.110.585042 · Cited by 67
Hayreh, S. S., & Zimmerman, M. B. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2008.08.007 · Cited by 64
Effect of Carotid Artery Stenting on Ocular Circulation and Chronic Ocular Ischemic Syndrome
Kawaguchi, S., Sakaki, T., Iwahashi, H., Fujimoto, K., Iida, J., Mishima, H., & Nishikawa, N. (2006) · Cerebrovascular Diseases · doi:10.1159/000094859 · Cited by 54
Blumenkranz, M. S., Haller, J. A., Kuppermann, B. D., Williams, G. A., Ip, M. S., Davis, M. D., Weinberg, D. V., Chou, C., & Whitcup, S. M. (2010) · Retina · doi:10.1097/iae.0b013e3181dcfaf3 · Cited by 45
Thrombolysis for Acute Central Retinal Artery Occlusion: Is it Time?
Biousse, V. (2008) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2008.07.025 · Cited by 42
Long-term Outcomes of Surgical Approaches to the Treatment of Floppy Eyelid Syndrome
Ezra, D. G., Beaconsfield, M., Sira, M., Bunce, C., Shah-Desai, S. D., Verity, D. H., Uddin, J. M., & Collin, R. (2010) · Ophthalmology · doi:10.1016/j.ophtha.2009.09.009 · Cited by 36
Hazin, R., Dixon, J. A., & Bhatti, M. T. (2009) · Current Opinion in Ophthalmology · doi:10.1097/icu.0b013e328329b5d5 · Cited by 27
Self-citationUse of antivascular endothelial growth factor for diabetic macular edema
Karim (2010) · Clinical ophthalmology · doi:10.2147/opth.s8980 · Cited by 27
Saitoh, M., MATSUO, K., NOMOTO, S., Kondoh, T., YANAGAWA, T., Katoh, Y., & Hasegawa, K. (1998) · Internal Medicine · doi:10.2169/internalmedicine.37.576 · Cited by 26
Management of Macular Edema from Retinal Vein Occlusions: You Can Never Have Too Many Choices
Bressler, N. M., & SCHACHAT, A. P. (2010) · Ophthalmology · doi:10.1016/j.ophtha.2010.03.037 · Cited by 24
Cohen, R., Padilla, J., Light, D. J., & Diller, R. S. (2010) · Optometry · doi:10.1016/j.optm.2009.10.013 · Cited by 21
Mills, D. M., Meyer, D. R., & Harrison, A. R. (2007) · Ophthalmology · doi:10.1016/j.ophtha.2007.01.037 · Cited by 21
Ocular ischemic syndrome: recent trends in medical management
Hazin, R., Daoud, Y. J., & Khan, F. (2009) · Current Opinion in Ophthalmology · doi:10.1097/icu.0b013e3283313d38 · Cited by 20
Self-citationPrograms to optimize adherence in glaucoma
Kowing, D., Messer, D. H., Slagle, W. S., & Wasik, A. J. (2010) · Optometry · doi:10.1016/j.optm.2009.09.021 · Cited by 19
Treatment of Thyroid Eye Disease
Phillips, M. E., Marzban, M. F., & Kathuria, S. S. (2010) · Current Treatment Options in Neurology · doi:10.1007/s11940-009-0054-0 · Cited by 19
Severe acute ocular ischemia associated with spontaneous internal carotid artery dissection
Takaki, Y., Nagata, M., Shinoda, K., Tatewaki, S., Yamada, K., Matsumoto, C. S., Hazuku, T., Yamashita, H., Ikebe, T., & Nakatsuka, K. (2007) · International Ophthalmology · doi:10.1007/s10792-007-9150-x · Cited by 17
Ten-year outcomes in newly diagnosed glaucoma patients: mortality and visual function
Sharma, T., & Salmon, J. F. (2007) · British Journal of Ophthalmology · doi:10.1136/bjo.2006.113274 · Cited by 17
Ocular Health in Sleep Apnea: A Comprehensive Overview
Hazin, R., Abuzetun, J. Y., Khan, F., & Bhatti, M. T. (2008) · Neuro-Ophthalmology · doi:10.1080/01658100802114786 · Cited by 2
Self-citationOphthalmic manifestations of endocrine disorders: approaches and medical management
Hendrick, A. M., Kahook, M. Y., Daoud, Y. J., & Hazin, R. (2009) · Current Opinion in Ophthalmology · doi:10.1097/icu.0b013e328331903c · Cited by 2
Self-citation
Research works printed but not linked: 1
- 10.1016/S0039-6257(04)00110-9 · DOI
Cited by
Sorted by citations
A large language model digital patient system enhances ophthalmology history taking skills
Luo, M.-J., Bi, S., Pang, J., Liu, L., Tsui, C.-K., Lai, Y., Chen, W., Yang, Y., Xu, K., Zhao, L., et al. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-01841-6 · Cited by 39
“Moreover,manyophthalmicconditions,suchas diabeticretinopathy,thyroid-associatedophthalmopathy,andsteroid-inducedcataracts,arerelatedtosystemicdiseases 55 , enhancing students ’ understanding of the interconnectedness of different body systems.”
Li, J., Gao, Z., Ning, L., Yao, L., Liu, C., Xu, C., Ren, X., Wang, A., Gao, S., Wang, M., et al. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s464524 · Cited by 5
Ophthalmic clues to the endocrine disorders
Liu, Z., Chen, Y., Lin, Z., & Shi, X. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0532-7 · Cited by 2
Eye as the First Manifestation Place of Various Systemical Diseases
Turgut, B. (2017) · Advances in Ophthalmology & Visual System · doi:10.15406/aovs.2017.07.00230
Validación de modelo de fantoma en simulación de fondo de ojo para alumnos de pregrado
Vargas-Sepúlveda, C., Salgado, L., Musa, P., Varas, J., & Grau, A. E. (2024) · Revista Latinoamericana de Simulación Clínica · doi:10.35366/115802
Metadata
- Authors
- Hazin, R., Lum, F., & Daoud, Y. J.
- Affiliations
- Massachusetts Eye and Ear Infirmary (US)
- American Academy of Ophthalmology (US)
- Johns Hopkins University (US)
- Corresponding author
- Daoud, Yassine J.
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2011-05-13
- Volume
- 44
- Issue
- 3
- Pages
- 242-252
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2118348276
- Cited by
- 6
- References
- 48
- Citations by year
- 2025: 2 · 2024: 2 · 2017: 1 · 2016: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal and Optic Conditions
- Health Sciences › Medicine › Ophthalmology › Ophthalmology and Visual Health Research
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- ocular manifestations of systemic disease, ocular manifestations, visual impairment
- MeSH terms
- Cardiovascular Diseases, Endocrine System Diseases, Eye, Eye Diseases, Humans, Lung Diseases, Disease Progression, Early Diagnosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review