The Frequency of Occurrence of Autoantibodies Against β1-Adrenoceptors and its Clinical Relevance in Patients with Hepatitis Virus Myocarditis
Abstract
The aim of this study was to examine the frequency of occurrence of autoantibodies against beta1-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correlation with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n=29) and a negative group (Non-HVM group, n=74) according to the laboratory findings regarding their type of hepatitis virus. The study parameters included UCG, ECG, biochemical findings and screening of autoantibodies against beta1-adrenoceptor. It was shown that the positive rate of the hepatitis virus was 28.16% (29/103) in patients with viral myocarditis. The severity of myocardial or liver injuries and the frequency of occurrence of autoantibodies against beta1-adrenoceptors in patients with viral myocarditis were more pronounced, before treatment, in the HVM group than in the Non-HVM group. The positive rates of the antibodies against the hepatitis virus and the autoantibodies against beta1-adrenoceptors were highly consistent in patients with HVM (p<0.05). In conclusion, the frequency of occurrence of the autoantibodies against beta1-adrenoceptors may be one important marker of HVM and, thus, possibly involved in the pathogenesis of the HVM.
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Autoantibodies targeting heart antigens are present in patients with viral myocarditis.
“numerous clinical studies have reported the presence of autoantibodies targeting heart antigens in patients with viral myocarditis”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [18]
In earlier studies, autoantibodies targeting heart antigens have been identified in both myocarditis patients and animal models, regardless of the underlying cause-viral infections or existing autoimmune conditions.
“In earlier studies, autoantibodies targeting heart antigens have been identified in both myocarditis patients and animal models, regardless of the underlying cause-viral infections or existing autoimmune conditions. 15-18,57,189,190,218”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [18]
Cites
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Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51 · see citing works
Inflammation and chronic heart failure–potential therapeutic role of intravenous immunoglobulin
Aukrust, P., Yndestad, A., Damås, J. K., & Gullestad, L. (2004) · Autoimmunity Reviews · doi:10.1016/s1568-9972(03)00103-4 · Cited by 37 · see citing works
The knowns and unknowns of cardiac autoimmunity in viral myocarditis
Mone, K., & Reddy, J. (2023) · Reviews in Medical Virology · doi:10.1002/rmv.2478 · Cited by 19 · see citing works
- Authors
- Wang, Z.-H., Liao, Y.-H., & Fu, M.
- Affiliations
- Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical University, Wuhan, 430022, China
- Sahlgrenska University Hospital (SE)
- Corresponding author
- Fu, Michael
- ORCID
- Fu, Michael
- Venue
- Autoimmunity
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 34
- Issue
- 4
- Pages
- 241-245
- ISSN
- 0891-6934 (ISSN-L)
- 1607-842X
- OpenAlex
- W2073617956
- Cited by
- 7
- References
- 1
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2012: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autoimmunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Keywords
- viral myocarditis, autoantibody frequency, myocardial injury, liver injury, disease severity
- MeSH terms
- Adult, Amino Acid Sequence, Autoantibodies, Female, Hepatitis, Viral, Human, Humans, Male, Middle Aged, Molecular Sequence Data, Myocarditis, Receptors, Adrenergic, beta-1
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