Cited by 37Cardiac Fibrosis and RemodelingHeart Failure Treatment and ManagementViral Infections and Immunology Research

Inflammation and chronic heart failure–potential therapeutic role of intravenous immunoglobulin

Aukrust, Pål, Yndestad, Arne, Damås, Jan Kristian, Gullestad, Lars·2004·Autoimmunity Reviews

Abstract

Accumulating evidence indicates that inflammatory cytokines play a pathogenic role in congestive heart failure (CHF) by influencing heart contractility, inducing hypertrophy and promoting apoptosis or fibrosis, contributing to the continuous myocardial remodelling process. Traditional cardiovascular drugs seem to have little influence on the overall cytokine network, and immunomodulatory therapy have emerged as a possible new treatment modality in CHF. Several animal studies have suggested that modulation of inflammatory cytokines may improve cardiac performance, and we have recently demonstrated that intravenous immunoglobulin enhances left ventricular ejection fraction in CHF patients, significantly correlated with anti-inflammatory effects of such therapy. While not necessarily the drugs of choice, these studies suggest a potential for immunomodulatory therapy in CHF in addition to optimal cardiovascular treatment regimens. Further research will have to more precisely identify the most important actors in the immunopathogenesis of CHF in order to develop more specific immunomodulating agents in this disorder. Although these shortcomings, we believe that the 'cytokine era' in cardiovascular research might lead to quite new treatment modalities in CHF patients potentially leading to reduced morbidity and mortality in these patients.

Integrity signals

Registry

Crossref · 10.1016/s1568-9972(03)00103-4

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  • Various proinflammatory cytokines can play a role in the myocardial remodeling process by directly influencing hypertrophy, apoptosis, fibrosis, and ultimately contractility.

    “There are now many reports indicating that the various proinflammatory cytokines can play a role in the myocardial remodeling process by directly influencing aspects such as hypertrophy, apoptosis, fibrosis, and ultimately contractility (20, 138).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [20]

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Authors
Aukrust, P., Yndestad, A., Damås, J. K., & Gullestad, L.
Affiliations
  • Oslo University Hospital (NO)
  • University of Oslo (NO)
Corresponding author
Aukrust, Pål
Venue
Autoimmunity Reviews
Publisher
Elsevier BV
Published
2004-03
Volume
3
Issue
3
Pages
221-227
ISSN
1568-9972 (ISSN-L)
OpenAlex
W2012253701
Cited by
37
References
40
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 1
FWCI
0.22
Type
journal article
Language
en
Open access
closed
Locations
  • Autoimmunity Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
Keywords
chronic heart failure, congestive heart failure, intravenous immunoglobulin, inflammation, inflammatory cytokines, immunomodulatory therapy, myocardial remodelling, left ventricular ejection fraction, cardiomyocyte apoptosis, myocardial fibrosis, heart failure pathogenesis
MeSH terms
Animals, Chronic Disease, Heart Failure, Humans, Inflammation, Myocardial Contraction, Predictive Value of Tests, Cytokines, Immunoglobulins, Intravenous

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