Inflammation and chronic heart failure–potential therapeutic role of intravenous immunoglobulin
Abstract
Accumulating evidence indicates that inflammatory cytokines play a pathogenic role in congestive heart failure (CHF) by influencing heart contractility, inducing hypertrophy and promoting apoptosis or fibrosis, contributing to the continuous myocardial remodelling process. Traditional cardiovascular drugs seem to have little influence on the overall cytokine network, and immunomodulatory therapy have emerged as a possible new treatment modality in CHF. Several animal studies have suggested that modulation of inflammatory cytokines may improve cardiac performance, and we have recently demonstrated that intravenous immunoglobulin enhances left ventricular ejection fraction in CHF patients, significantly correlated with anti-inflammatory effects of such therapy. While not necessarily the drugs of choice, these studies suggest a potential for immunomodulatory therapy in CHF in addition to optimal cardiovascular treatment regimens. Further research will have to more precisely identify the most important actors in the immunopathogenesis of CHF in order to develop more specific immunomodulating agents in this disorder. Although these shortcomings, we believe that the 'cytokine era' in cardiovascular research might lead to quite new treatment modalities in CHF patients potentially leading to reduced morbidity and mortality in these patients.
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Various proinflammatory cytokines can play a role in the myocardial remodeling process by directly influencing hypertrophy, apoptosis, fibrosis, and ultimately contractility.
“There are now many reports indicating that the various proinflammatory cytokines can play a role in the myocardial remodeling process by directly influencing aspects such as hypertrophy, apoptosis, fibrosis, and ultimately contractility (20, 138).”
From Cardiac remodeling in obesity (2008) · cites this paper as [20]
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- Authors
- Aukrust, P., Yndestad, A., Damås, J. K., & Gullestad, L.
- Affiliations
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Corresponding author
- Aukrust, Pål
- Venue
- Autoimmunity Reviews
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 3
- Issue
- 3
- Pages
- 221-227
- ISSN
- 1568-9972 (ISSN-L)
- OpenAlex
- W2012253701
- Cited by
- 37
- References
- 40
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autoimmunity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Keywords
- chronic heart failure, congestive heart failure, intravenous immunoglobulin, inflammation, inflammatory cytokines, immunomodulatory therapy, myocardial remodelling, left ventricular ejection fraction, cardiomyocyte apoptosis, myocardial fibrosis, heart failure pathogenesis
- MeSH terms
- Animals, Chronic Disease, Heart Failure, Humans, Inflammation, Myocardial Contraction, Predictive Value of Tests, Cytokines, Immunoglobulins, Intravenous
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