CoChat
Sign Up
Cited by 95

The DOI matches its Crossref record.

Studies on the Chronic Toxicity (Inhalation) Of Four Types of Refractory Ceramic Fiber in Male Fischer 344 Rats

Mast, R. W., McConnell, E. E., Anderson, R., Chevalier, J, Kotin, P., Bernstein, D. M., Thevenaz, P., Glass, L. R., Miiller, W. C., Hesterberg, T. W.·1995·Inhalation Toxicology
DOI 10.3109/08958379509015208
Open this paper in CoChat — free account

Abstract

Refractory ceramic fibers (RCF) are man-made vitreous fibers used primarily in industrial high-temperature applications, especially for insulation of furnaces and kilns. Because of their increasing use and potential for human exposure, a chronic toxicity/carcinogenicity inhalation study was conducted in Fischer 344 (F344) rats. Five groups of 140 weanling male F344 rats were exposed via noseonly inhalation to either HEPA-filtered air (chamber controls) or 30 mg/m(3) (approximately 220 fibers/cm(3)) of three types [kaolin-based, high-purity, and aluminum zirconia silica (AZS)] of "size-selected" RCF fibers (approximately 1µ in diameter and approximately 20 um in length) and an "after-service" heat-treated (2400°F for 24 h) kaolin-based fiber for 6 h/day, 5 days/wk for 24 mo. They were then held unexposed until approximately 20% survival and then sacrificed at 30 mo. A positive control group of 80 F344 rats was exposed to 10 mg/m(3) chrysotile asbestos. Croups of 3-6 animals were sacrificed at 3, 6, 9, 12, 15, 18, and 24 mo to follow the progression of lesions and to determine fiber lung burdens. Additional groups of 3 rats were removed from exposure at 3, 6, 9, 12, and 18 mo and were held until sacrificed at 24 mo (recovery groups) for similar determinations. Lung burdens increased rapidly for all RCFs, appearing to plateau by about 12 mo. By 24 mo, lung burdens ranged from 2.6 to 9.6 × 10(5) fiberslmg of dry lung tissue for the RCFs tested. Treatment-related lesions were rest…

Overview

Integrity signals

Registry

Crossref · 10.3109/08958379509015208

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 47

  1. 10.1289/ehp.898181 · DOI
  2. Baumgartner H., 1980, Beitr. Tabakforsch. Int., 10, 169
  3. Bellmann B., 1987, Ann. Occup. Hyg., 31, 693, 10.1093/annhyg/31.4B.693 · DOI
  4. Bernstein D. M., 1980, Environ. Health Perspect., 34, 47, 10.1289/ehp.803447 · DOI
  5. Boorman G. A., 1990, Pathology of the Fischer rat, 339
  6. Brown G. M., 1986, Carcinogenesis, 7, 1971, 10.1093/carcin/7.12.1971 · DOI · Paper page
  7. 10.1080/15298668391405959 · DOI
  8. Davis J. M. G., 1984, Biological effects of man-made mineral fibers, Vol. 2, 303
  9. Gross P., 1956, AM A Arch. Ind. Health, 13, 161
  10. Hammad Y., 1988, Ann. Occup. Hyg., 32, 769, 10.1093/annhyg/32.inhaled_particles_VI.769 · DOI
  11. Hammad Y. Y, 1984, Biological effects of man-made mineral fibers, Vol. 2, 126
  12. Harrington J. S., 1975, Adv. Pharmacol. Chemother., 12, 291, 10.1016/S1054-3589(08)60223-9 · DOI
  13. Harrington J. S, 1981, J. Natl. Cancer Inst., 67, 977
  14. Hart G. A., 1992, Toxicol. In Vitro, 6, 317, 10.1016/0887-2333(92)90021-I · DOI
  15. Hesterberg T. W., 1991, Cellular and molecular aspects of fiber carcinogenesis, 183
  16. Holland L. M., 1983, Health issues related to metal and nonmetallic mining, 486
  17. Holland L. M., 1986, Silica, silicosis, and cancer. Controversy in occupational medicine, 267
  18. IARC, 1977, Asbestos
  19. IARC, 1987, Silica and some silicates
  20. IPCS, 1988, Man-Made Mineral Fibers
  21. Jaurand M. C, 1989, Nonoccupational exposure to mineral fibres, 54
  22. Lauweryns J. M., 1977, Am. Rev. Respir. Dis., 115, 625
  23. Law B. D., Solubility of natural mineral and man-made vitreous fibers in Karnovsky's and formalin fixatives
  24. Lemasters G., Radiographic changes among workers manufacturing refractory ceramic fiber and products
  25. Lippman M, 1988, Environ. Res., 46, 86, 10.1016/S0013-9351(88)80061-6 · DOI
  26. McClellan R. O., 1992, Regul. Toxicol. Pharmacol., 16, 321, 10.1016/0273-2300(92)90011-W · DOI
  27. McConnell E. E, 1989, I. Am. Coll. Toxicol., 6, 1115, 10.3109/10915818909018071 · DOI
  28. 10.3109/08958379509015210 · DOI · Paper page
  29. Monchaux G., 1982, Ann. Occup. Hyg., 26, 309, 10.1093/annhyg/26.2.309 · DOI
  30. Morgan A., 1984, Biological effects of man-made mineral fibres, Vol. 2, 1
  31. 10.1016/0272-0590(88)90284-9 · DOI · Paper page
  32. Mossman B. T., 1989, Environ. Health Perspect., 81, 91, 10.1289/ehp.898191 · DOI
  33. 10.1080/15287398409530601 · DOI
  34. Pott F., 1987, Exp. Pathol., 82, 129, 10.1016/S0232-1513(87)80044-0 · DOI
  35. Raabe O. G., 1989, Ann. Occup. Hyg., 32, 53, 10.1093/annhyg/32.inhaled_particles_VI.53 · DOI
  36. Refractory Ceramic Fiber Coalition, 1992, Refractory Ceramic Fiber Background Briefing Material
  37. Saracci R, 1985, Scand. J. Work Environ. Health, 11, 215, 10.5271/sjweh.2232 · DOI
  38. Scholze H, 1988, Glastecb. Ber., 166, 61
  39. Smith W. E., 1965, Ann. Occup. Hyg., 31, 731, 10.1093/annhyg/31.4B.731 · DOI
  40. Stanton M., 1981, J. Natl. Cancer Inst., 67, 965
  41. Thermal Insulation Manufacturers Association, 1991, Health and Safety Aspects of Man-Made Vitreous Fibers. Report to NIOSH, July 10
  42. Thomas R. C., 1979, Int. J. Cancer, 24, 594, 10.1002/ijc.2910240512 · DOI
  43. U.S. Environmental Protection Agency, 1984, Asbestos Health Assessment Update. EPA-600/8–84–003A
  44. Wagner J. C, 1973, Br. J. Cancer, 28, 173, 10.1038/bjc.1973.134 · DOI · Paper page
  45. Wagner J., 1974, Br. I. Cancer, 29, 252, 10.1038/bjc.1974.65 · DOI
  46. World Health Organization. Reference Methods for Measuring Man-Made Mineral Fibers (MMMF), 1985, Prepared by WHO/EURO Technical Committee for evaluating MMMF
  47. Wright A., 1986, Am. J. Ind. Med., 9, 371, 10.1002/ajim.4700090409 · DOI

Cited by

Sorted by citations

See all 95

Metadata

Authors
Mast, R. W., McConnell, E. E., Anderson, R., Chevalier, J., Kotin, P., Bernstein, D. M., Thevenaz, P., Glass, L. R., Miiller, W. C., & Hesterberg, T. W.
Venue
Inhalation Toxicology
Publisher
Informa UK Limited
Published
1995-01
Volume
7
Issue
4
Pages
425-467
ISSN
  • 0895-8378
  • 1091-7691
DOI
10.3109/08958379509015208
Cited by
95
References
0
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Studies on the Chronic Toxicity (Inhalation) Of Four Types of Refractory Ceramic Fiber in Male Fischer 344 Rats. https://app.cochat.ai/papers/10.3109/08958379509015208
The paper
Mast, R. W., McConnell, E. E., Anderson, R., Chevalier, J., Kotin, P., Bernstein, D. M., Thevenaz, P., Glass, L. R., Miiller, W. C., & Hesterberg, T. W. (1995). Studies on the Chronic Toxicity (Inhalation) Of Four Types of Refractory Ceramic Fiber in Male Fischer 344 Rats. Inhalation Toxicology. https://doi.org/10.3109/08958379509015208