The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Structure, Evolution, Expression and Regulation of Insulin-Like Growth Factors I and II
Abstract
Insulin-like growth factors (IGF) I and II are chemically-related single-chain peptides with diverse actions on cellular growth and metabolism. This review will focus on recent information pertinent to the biochemical and molecular biological aspects of these peptides. Three areas will be examined: The structure of the two IGF molecules and their precursors will be analyzed; the complicated anatomy of the IGF genes and their mRNAs will be described; and the multiple ways in which the expression of IGF-I and IGF-II can be regulated will be discussed. Gaps in our understanding of these peptides will be highlighted in the context of opportunities for further investigation in this field.
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Cites
Voutilainen, R., & Miller, W. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.6.1590 · Cited by 238
Cortisol inhibits the synthesis of insulin-like growth factor-I in skeletal cells.
MCCARTHY, T. L., CENTRELLA, M., & CANALIS, E. (1990) · Endocrinology · doi:10.1210/endo-126-3-1569 · Cited by 204
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Ye, P., Li, L., Richards, R. G., DiAugustine, R. P., & D'Ercole, A. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06041.2002 · Cited by 225
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Metadata
- Authors
- Rotwein, P.
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 1991-01
- Volume
- 5
- Issue
- 1
- Pages
- 3-18
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W2017124406
- Cited by
- 252
- References
- 2
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Structure, Evolution, Expression and Regulation of Insulin-Like Growth Factors I and II. https://app.cochat.ai/papers/10.3109/08977199109000267
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- Rotwein, P. (1991). Structure, Evolution, Expression and Regulation of Insulin-Like Growth Factors I and II. Growth Factors. https://doi.org/10.3109/08977199109000267
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
