Chemical transmission in the sea anemone Nematostella vectensis: a genomic perspective

Anctil, Michel

doi:10.1016/j.cbd.2009.07.001

Cited by 139Marine Invertebrate Physiology and EcologyNeuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology Research

Chemical transmission in the sea anemone Nematostella vectensis: a genomic perspective

Anctil, Michel·2009·Comparative Biochemistry and Physiology Part D Genomics and Proteomics

DOI 10.1016/j.cbd.2009.07.001

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Abstract

The sequencing of the starlet sea anemone (Nematostella vectensis) genome provides opportunities to investigate the function and evolution of genes associated with chemical neurotransmission and hormonal signaling. This is of particular interest because sea anemones are anthozoans, the phylogenetically basal cnidarians least changed from the common ancestors of cnidarians and bilaterian animals, and because cnidarians are considered the most basal metazoans possessing a nervous system. This analysis of the genome has yielded 20 orthologues of enzymes and nicotinic receptors associated with cholinergic function, an even larger number of genes encoding enzymes, receptors and transporters for glutamatergic (28) and GABAergic (34) transmission, and two orthologues of purinergic receptors. Numerous genes encoding enzymes (14), receptors (60) and transporters (5) for aminergic transmission were identified, along with four adenosine-like receptors and one nitric oxide synthase. Diverse neuropeptide and hormone families are also represented, mostly with genes encoding prepropeptides and receptors related to varying closeness to RFamide (17) and tachykinin (14), but also galanin (8), gonadotropin-releasing hormones and vasopressin/oxytocin (5), melanocortins (11), insulin-like peptides (5), glycoprotein hormones (7), and uniquely cnidarian peptide families (44). Surprisingly, no muscarinic acetylcholine receptors were identified and a large number of melatonin-related, but not serotonin, orthologues were found. Phylogenetic tree construction and inspection of multiple sequence alignments reveal how evolutionarily and functionally distant chemical transmitter-related proteins are from those of higher metazoans.

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There is a discrepancy between bioinformatic data and empirical data, specifically the lack of serotonin orthologues in reference [37] with serotonin immunostaining in reference [26] in Nematostella.
“Also, one has to take into account the discrepancy of bioinformatic data with the empirical data (lack of serotonin orthologues in reference [37], with serotonin immunostaining in reference [26] in Nematostella).”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [37]
Bioinformatic analysis of the Nematostella genome has shown that a large number of genes associated with chemical neurotransmission are present.
“Bioinformatic analysis of the Nematostella genome has shown that a large number of genes associated with chemical neurotransmission are present [37].”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [37]
The assignment of cnidarian genes to a receptor class was based exclusively on homology to bilaterian receptors.
“the assignment of cnidarian genes to a receptor class was exclusively based on homology to bilaterian receptors [52]”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [52]
The cnidarian nervous system extensively, and perhaps predominantly, uses neuropeptides.
“the cnidarian nervous system extensively, and perhaps predominately, uses neuropeptides [52,55]”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [52]
In Nematostella, the diversity of neuropeptides is matched by over 80 putative GPCRs for neuropeptides.
“In Nematostella the diversity of neuropeptides is matched by over 80 putative GPCRs for neuropeptides [52].”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [52]

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Huttenlocher (1997) · doi:10.1002/(sici)1096-9861(19971020)387:2
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Functional analysis in a model sea anemone reveals phylogenetic complexity and a role in cnidocyte discharge of DEG/ENaC ion channelsPreprint
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Authors: Anctil, M.
Affiliations: Université de Montréal (CA)
Corresponding author: Anctil, Michel
Venue: Comparative Biochemistry and Physiology Part D Genomics and Proteomics
Publisher: Elsevier BV
Published: 2009-12
Volume: 4
Issue: 4
Pages: 268-289
ISSN: 1744-117X (ISSN-L)
DOI: 10.1016/j.cbd.2009.07.001
OpenAlex: W2143838640
Cited by: 139
References: 183
Citations by year: 2026: 4 · 2025: 4 · 2024: 11 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 27 · 2019: 11 · 2018: 11 · 2017: 3 · 2016: 7 · 2015: 13 · 2014: 12 · 2013: 4 · 2012: 7
FWCI: 3.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Comparative Biochemistry and Physiology Part D Genomics and Proteomics (publishedVersion)
PubMed (publishedVersion)
Funders: Natural Sciences and Engineering Research Council of Canada
Topics: Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: Nematostella vectensis, chemical neurotransmission, cnidarian nervous system, Anthozoa, cholinergic neurotransmission, nicotinic acetylcholine receptors, glutamatergic neurotransmission, GABAergic neurotransmission, purinergic receptors, neuropeptides, hormones, RFamide, tachykinins, galanin, gonadotropin-releasing hormone, melanocortin peptides, insulin-like peptides, glycoprotein hormones, melatonin, serotonin, genome annotation
MeSH terms: Animals, Hormones, Nervous System, Neuropeptides, Sea Anemones, Genome, Neurotransmitter Agents

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Chemical transmission in the sea anemone Nematostella vectensis: a genomic perspective

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