Basal serum testosterone levels correlate with ovarian reserve and ovarian response in cycling women undergoing in vitro fertilization
Abstract
This study aimed to investigate the association between basal serum testosterone levels and in vitro fertilization (IVF) parameters in cycling women. A retrospective cohort study was performed at a clinical IVF center, and 495 women with regular menstruation were enrolled. Serum testosterone levels were measured before the start of IVF treatment cycle. We found that basal serum testosterone levels were negatively associated with female age and FSH/LH ratios. In contrast, we found a positive correlation between serum testosterone levels and the number of oocytes and available embryos. However, there was no significant association between testosterone levels and pregnancy outcome. Our results suggest that basal serum testosterone levels were significantly related to certain classic indicators of ovarian reserve, such as age and FSH/LH ratios. Increased testosterone levels improved ovarian response in cycling women, but they fail to predict pregnancy and miscarriage rate.
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In regularly menstruating women without endometriosis or PCOS, serum testosterone levels positively predict number of follicles and oocytes retrieved.
“In regularly menstruating women without endometriosis or PCOS, serum testosterone levels positively predict number of follicles and oocytes retrieved (Sun et al., 2014; Xiao et al., 2016),”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Xiao et al., 2016
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- Authors
- Xiao, S., Li, Y., Long, L., Luo, C., & Mai, Q.
- Affiliations
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Corresponding author
- Li, Yubin
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2015-08-21
- Volume
- 32
- Issue
- 1
- Pages
- 51-54
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W2149277099
- Cited by
- 15
- References
- 25
- Citations by year
- 2025: 5 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2019: 1 · 2017: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- ovarian reserve, ovarian response, in vitro fertilization, FSH/LH ratio, maternal age, oocyte yield, embryo yield, pregnancy outcomes, miscarriage, anovulatory women
- MeSH terms
- Abortion, Spontaneous, Adult, Age Factors, Female, Fertilization in Vitro, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Middle Aged, Oocytes, Ovulation Induction, Pregnancy, Pregnancy Outcome, Prognosis, Retrospective Studies, Testosterone, Cohort Studies, Treatment Outcome, Young Adult, Ovarian Reserve
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