The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
The biology of depression in cancer and the relationship between depression and cancer progression
Abstract
The prevalence of depressive symptoms in patients with cancer exceeds that observed in the general population and depression is associated with a poorer prognosis in cancer patients. The increased prevalence is not solely explained by the psychosocial stress associated with the diagnosis. Pro-inflammatory cytokines, which induce sickness behaviour with symptoms overlapping those of clinical depression, are validated biomarkers of increased inflammation in patients with cancer. A growing literature reveals that chronic inflammatory processes associated with stress may also underlie depression symptoms in general, and in patients with cancer in particular. Therapeutic modalities, which are frequently poorly tolerated, are used in the treatment of cancer. These interventions are associated with inflammatory reactions, which may help to explain their toxicity. There is evidence that antidepressants can effectively treat symptoms of depression in cancer patients though the database is meager. Novel agents with anti-inflammatory properties may be effective alternatives for patients with treatment-resistant depression who exhibit evidence of increased inflammation.
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Cites
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Cited by
Liu, Q., He, H., Yang, J., Feng, X., Zhao, F., & Lyu, J. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.08.002 · Cited by 1,452
Depression in cancer: The many biobehavioral pathways driving tumor progression
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Endometriosis and cancer: a systematic review and meta-analysis
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Burden of depression in China, 1990–2017: Findings from the global burden of disease study 2017
Ren, X., Yu, S., Dong, W., Yin, P., Xu, X., & Zhou, M. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.011 · Cited by 234
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Metadata
- Authors
- Sotelo, J. L., Musselman, D., & Nemeroff, C.
- Venue
- International Review of Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2014-02
- Volume
- 26
- Issue
- 1
- Pages
- 16-30
- ISSN
- 0954-0261 (ISSN-L)
- 1369-1627
- OpenAlex
- W2099725757
- Cited by
- 179
- References
- 50
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sotelo, J. L., Musselman, D., & Nemeroff, C. (2014). The biology of depression in cancer and the relationship between depression and cancer progression. International Review of Psychiatry. https://doi.org/10.3109/09540261.2013.875891
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
