Effects of ginger ( Zingiber officinale ) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients
Abstract
The present study was aimed to evaluate the effects of Zingiber officinale on some biochemical parameters in type 2 diabetic (DM2) patients. In a randomized double-blind placebo controlled trial, 64 patients with DM2 were assigned to ginger or placebo groups (receiving 2 g/d of each). A 3 d diet record, anthropometric measurements and concentrations of fasting blood glucose (FPG), HbA1c, lipid profile (including total cholesterol, triglyceride, low density lipoprotein and high density lipoprotein) and also the homeostasis model assessment (HOMA) and quantitative insulin-sensitivity check index (QUICKI) were determined before and after 2 months of intervention. Ginger supplementation significantly lowered the levels of insulin (11.0 ± 2.3 versus 12.1 ± 3.3; p = 0.001), LDL-C (67.8 ± 27.2 versus 89.2 ± 24.9; p = 0.04), TG (127.7 ± 43.7 versus 128.2 ± 37.7; p = 0.03) and the HOMA index (3.9 ± 1.09 versus 4.5 ± 1.8; p = 0.002) and increased the QUICKI index (0.313 ± 0.012 versus 0.308 ± 0.012; p = 0.005) in comparison to the control group; while, there were no significant changes in FPG, TC, HDL-C and HbA1c (p > 0.05). In summary, ginger supplementation improved insulin sensitivity and some fractions of lipid profile in DM2 patients. Therefore it may be considered as a useful remedy to reduce the secondary complications of DM2.
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Ginger and placebo tablets were identical in package, size, shape, and color, and a small amount of ginger powder was added to placebo bottles to give ginger odor.
“It is noteworthy that ginger and placebo tablets were exactly the same in package, size, shape, and color. Moreover, a very small amount of ginger powder was added to bottles containing placebo tablets to give ginger odor, as previously done by Mahluji et al. [21] and Ebrahimzadeh Attari et al. [22].”
Cites
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Henriksen, E. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.002 · Cited by 136 · cited 1× · see citing works
“Although the exact mechanisms of the action of these compounds are not well-understood, they might result from the increased protein content of GLUT-4, insulin receptors and enhanced b-cell functions (Henriksen, 2006).”
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Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe)
Mao, Q.-Q., Xu, X.-Y., Cao, S.-Y., Gan, R.-Y., Corke, H., Beta, T., & Li, H.-B. (2019) · Foods · doi:10.3390/foods8060185 · Cited by 1,418 · see citing works
Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials
Anh, N. H., Kim, S. J., Long, N. P., Min, J. E., Yoon, Y. C., Lee, E. G., Kim, M., Kim, T. J., Yang, Y. Y., Son, E. Y., et al. (2020) · Nutrients · doi:10.3390/nu12010157 · Cited by 227 · see citing works
Wang, J., Ke, W., Bao, R., Hu, X., & Chen, F. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13375 · Cited by 167 · see citing works
Maharlouei, N., Tabrizi, R., Lankarani, K. B., Rezaianzadeh, A., Akbari, M., Kolahdooz, F., Rahimi, M., Keneshlou, F., & Asemi, Z. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1427044 · Cited by 99 · see citing works
Ebrahimzadeh, A., Ebrahimzadeh, A., Mirghazanfari, S. M., Hazrati, E., Hadi, S., & Milajerdi, A. (2022) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2022.102802 · Cited by 38 · see citing works
Foshati, S., Poursadeghfard, M., Heidari, Z., & Amani, R. (2023) · Food & Function · doi:10.1039/d3fo00167a · Cited by 12 · see citing works
Foshati, S., Poursadeghfard, M., Heidari, Z., & Amani, R. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04227-x · Cited by 11 · see citing works
“Moreover, a very small amount of ginger powder was added to bottles containing placebo tablets to give ginger odor, as previously done by Mahluji et al. [21] and Ebrahimzadeh Attari et al. [22].”
Method
- Authors
- Mahluji, S., Attari, V. E., Mobasseri, M., Payahoo, L., Ostadrahimi, A., & Golzari, S. E.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Imam Reza Hospital (IR)
- Corresponding author
- Ostadrahimi, Alireza
- Venue
- International Journal of Food Sciences and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2013-03-18
- Volume
- 64
- Issue
- 6
- Pages
- 682-686
- ISSN
- 0963-7486 (ISSN-L)
- 1465-3478
- OpenAlex
- W2053981745
- Cited by
- 153
- References
- 2
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 9 · 2023: 21 · 2022: 20 · 2021: 15 · 2020: 11 · 2019: 12 · 2018: 10 · 2017: 8 · 2016: 5 · 2015: 10 · 2014: 9 · 2013: 1
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Food Sciences and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginger and Zingiberaceae research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Keywords
- ginger, type 2 diabetes, insulin sensitivity, plasma glucose, HbA1c, lipid profile, LDL cholesterol, triglycerides, HOMA, QUICKI, dietary supplementation
- MeSH terms
- Adult, Aged, Hypolipidemic Agents, Blood Glucose, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Glycated Hemoglobin, Humans, Hyperglycemia, Hyperinsulinism, Hyperlipidemias, Hypoglycemic Agents, Insulin Resistance, Male, Middle Aged, Dietary Supplements, Zingiber officinale, Rhizome, Diabetes Complications
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